Friction stir welding was used to consolidate 2-mm-thick Ti-6Al-4V titanium alloy sheets, and the static and fatigue properties of the joint were investigated. The results reveal that uniform microhardness distribution of the nugget zone (NZ) after post-weld heat treatment was associated with the uniform equiaxed microstructure of the NZ. The joint fatigue limit predicted by the S–N curve reached 640.84 MPa, up to 64.76% of joint tensile strength. Fatigue specimens fractured at the transition zone between the base material and NZ, and the positions of fatigue crack initiation sites were relatively random. The fracture surface of the fatigue crack propagation region was composed of radial strips and striations, and numerous dimples were observed on the final fast fracture surface.