Final Event Research Articles

The Precursory 3D Displacement Patterns and Their Implicit Collapse Mechanism of the Ice-Rock Avalanche Events Occurred in Sedongpu Basin Revealed by Optical and SAR Observations

Quantifying the kinematic evolution patterns of mountain glaciers near Yarlung Tsanpo River performs a major role in evaluating the glacial instability and the secondary disasters. For the Sedongpu Basin near the Yarlung Tsanpo River Valley, the dramatic geomorphic landscape variations triggered by the ice-rock avalanche events were visually identified as the dominant texture deficiencies in time-series optical images. To improve the image correlation quality broken by these image texture deficiencies, the Landsat-8/Sentinel-2 optical images were divided into different groups, then a stepwise combination strategy was innovatively proposed to derive the glacier time-series displacement velocities in different temporal stages. The standard deviations (STD) of the optical measurements in the stable area maintained around 0.04 m/yr for the normalized displacement velocity and maintained from 0.6 to 1.7 m for the cumulative displacement time series. The obvious variations in glacier displacement velocity were identified before each collapse event. Subsequently, the offset-tracking procedures were performed on 7 Sentinel-1A Synthetic Aperture Radar (SAR) images to acquire the range and azimuth displacement velocities. To better reveal the dynamic mechanism of the glacier activity, the three-dimensional (3D) glacial displacement velocity was also derived by using optical and SAR results. The precipitation, temperature, and seismic activities were assumed as the main triggering factors of controlling the glacial dynamic mechanism and final collapse events. Additionally, the dynamic mechanism of the active glaciers in Sedongpu Basin conformed to a power law, which was limited by the changes of the internal stress friction force on the sliding base surface. The aim of this study is to shed a light on interpreting the precursory displacement patterns and their implicit failure mechanism of these ice-rock avalanche events with the conventional freely optical and SAR observations.

Análisis de supervivencia

Survival analysis is a statistical method that assesses the time between an initial event (inclusion of the subject in the study) and a final event, which occurs when the subject presents a previously defined characteristic. Its objective is to estimate, taking into account the time variable, the probability of a certain event occurring. It has the particularity of accepting incomplete participation times and assuming that all the factors involved in the study are homogeneous. There are several methods to calculate the probability of survival, the most used are the Kaplan-Meier and the actuarial.

Glucolipotoxic Stress-Induced Mig6 Desensitizes EGFR Signaling and Promotes Pancreatic Beta Cell Death.

A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and therefore treat/prevent T2D, growth factors have been considered therapeutically but have largely failed to achieve robust clinical success. The molecular mechanisms preventing the activation of mitogenic signaling pathways from maintaining functional beta cell mass during the development of T2D remain unknown. We speculated that endogenous negative effectors of mitogenic signaling cascades impede beta cell survival/expansion. Thus, we tested the hypothesis that a stress-inducible epidermal growth factor receptor (EGFR) inhibitor, mitogen-inducible gene 6 (Mig6), regulates beta cell fate in a T2D milieu. To this end, we determined that: (1) glucolipotoxicity (GLT) induces Mig6, thereby blunting EGFR signaling cascades, and (2) Mig6 mediates molecular events regulating beta cell survival/death. We discovered that GLT impairs EGFR activation, and Mig6 is elevated in human islets from T2D donors as well as GLT-treated rodent islets and 832/13 INS-1 beta cells. Mig6 is essential for GLT-induced EGFR desensitization, as Mig6 suppression rescued the GLT-impaired EGFR and ERK1/2 activation. Further, Mig6 mediated EGFR but not insulin-like growth factor-1 receptor nor hepatocyte growth factor receptor activity in beta cells. Finally, we identified that elevated Mig6 augmented beta cell apoptosis, as Mig6 suppression reduced apoptosis during GLT. In conclusion, we established that T2D and GLT induce Mig6 in beta cells; the elevated Mig6 desensitizes EGFR signaling and induces beta cell death, suggesting Mig6 could be a novel therapeutic target for T2D.

Viking Strong by Doug Cenko

Reviewed by: Viking Strong by Doug Cenko Meg Cornell Cenko, Doug Viking Strong; written and illus. by Doug Cenko. Viking, 2023 [48p] Trade ed. ISBN 9780593202326 $18.99 E-book ed. ISBN 9780593202319 $10.99 Reviewed from digital galleys R 3-6 yrs Vikings Ingrid and Stig share a fun life making delicious stews, having high seas adventures, and dressing up their cats in silly outfits, but the two friends get focused when Ingrid wants to compete in the "Strongest Viking Contest." While sporty Ingrid can likely sail through most rounds of the competition ("Lifting of Really Heavy Things!" and the "Running of the Kittens!"), she doesn't know how to swim and therefore won't be able to make her way across the sea to the event's finish line. Despite continued attempts and Stig's moral support, Ingrid keeps sinking morosely to bottom. She still decides to compete, however, and at the final event, Stig hands her a floatie—but it turns out she's not the only participant to struggle with swimming, as all her Viking competitors, in wacky beach wear, have flotation devices too. Buoyant colors contrast with neutral-toned backgrounds, and figures have an approachable cartoonish style, with varied, energetic shapes that convey the rowdy joy of the Viking contests and characters. Endpapers bring added interest with Viking art and early medieval interlace designs while cat-crazy kids will be especially pleased with the sheer variety of adorable felines incorporated across this book. As in Cenko's previous Viking in Love (BCCB 11/21), inclusive character design and affirmation of non-traditional gender expression make this an exuberant and supportive addition to any collection, especially as Ingrid reconsiders what Viking strength means to her. [End Page 286] Copyright © 2023 The Board of Trustees of the University of Illinois

Quantitative Analysis of Ovarian Dynamics of European Sardine Sardina pilchardus (Walbaum, 1792) during Its Spawning Period

Fish with indeterminate fecundity spawn multiple times throughout a protracted reproductive period. During that period several ovulation events succeed one another, and different oocyte developmental stages co-occur in the ovaries with new oocytes consistently recruiting from one growth phase to the next to form the sequential batches. In this study, we examined in detail the oocyte recruitment and development pattern of the sequential batches in a commercially important fish with indeterminate fecundity, the European sardine. The numbers and sizes of oocytes at different developmental stages were estimated for four phases of the ovulatory cycle (ovarian stages) and during the main spawning season (November–March) by applying the oocyte packing density theory in combination with stereological techniques. General linear models (GLMs) were used to test for changes in oocyte sizes as well as relative oocyte numbers per developmental stage within the different ovarian stages in the successive spawning months. A temporal association between several transition events of the oocyte development process was revealed. Specifically, the final maturation of the advanced batch triggered (a) the recruitment of oocytes from primary to secondary growth phase, (b) de novo vitellogenesis and (c) a surge of yolk deposition in primary vitellogenic oocytes. Oocyte recruitment was completed two days after the ovulation of the advanced batch and relative numbers of primary and secondary growth oocytes were thereafter stable until the next final maturation event. This pattern of oocyte recruitment and growth remained unchanged during the course of the spawning season. This study advances our knowledge on oocyte recruitment and development in fish with indeterminate fecundity, which is key to understanding reproduction and its drivers at the individual and population level.

Abstract 1622: Ecubectedin is a novel transcriptional inhibitor that displays potent antitumor effects in vitro and in vivo

Abstract Background - Ecubectedin (PM14) is a novel transcriptional inhibitor related to ecteinascidins family. In this work, we present its antiproliferative activity and mechanism of action. The in vitro antitumor activity obtained in cellular models has been also demonstrated in in vivo models. Methods and results - The antineoplastic activity of ecubectedin was evaluated in a panel of cell lines representative of different solid human cancers, by MTT assays. Ecubectedin exhibits potent antitumor in vitro activity with mean GI50 values in the very low nanomolar range. Electrophoretic Mobility Shift assays demonstrate that ecubectedin binds to DNA and experiments of 3H-uridine incorporation show that the drug efficiently inhibits mRNA synthesis (85% reduction after 90 min). Moreover, ecubectedin specifically inhibits transactivated transcription, as evaluated in a reporter system of the transcriptional activity mediated by NF-κB after activation with TNFα. In the presence of ecubectedin, transactivation was almost completely abolished. The mechanism of transcriptional inhibition involves the stalling and irreversible proteasomal degradation of elongating RNA Pol II. As a final event, ecubectedin induces double strand breaks in the DNA, inducing cell cycle arrest in the S-phase that can be followed through flow cytometry and triggers apoptotic death of the tumor cell as seen through Annexin V flow cytometry assays. The in vivo antitumor activity of ecubectedin was characterized in xenografted tumors of human origin in athymic nu/nu mice, namely breast (MDA-MB-231), soft tissue sarcoma (HT-1080), SCLC (H526 and H82) and prostate (22Rv1). Ecubectedin was intravenously administered (at 1.25 mg/kg) on days 0, 7 and 14. Compared to placebo, ecubectedin treatment of mice bearing xenografts resulted in a statistically significant reduction of volume in MDA-MB-231 (p≤0.0005 on days 7-35), HT-1080 (p≤0.0004 on days 2-14), H82 (p≤0.0001 on days 5-14), H526 (p≤0.0001 from day 4 to the end of the experimental period), and 22Rv1 (p≤0.0001 on days 3-14) tumors. In mice bearing MDA-MB-231, H526 and 22Rv1 tumors, complete tumor remissions were seen in 1/10 (lasting 103 days), 9/10 (lasting 220 days) and 7/10 (lasting 13 days) ecubectedin-treated animals, respectively. Conclusions - Ecubectedin is a novel transcriptional inhibitor that displays potent antiproliferative activity in different human solid cancer models in vitro and in vivo. The drug is currently in clinical development in Phase II trials. Citation Format: Gema Santamaría Nuñez, Marta Martínez Diez, María José Guillén, Eva Maria Garrido-Martin, Pablo Avilés, Carmen Cuevas. Ecubectedin is a novel transcriptional inhibitor that displays potent antitumor effects in vitro and in vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1622.

Tranexamic acid-associated intrathecal toxicity during spinal anaesthesia: A narrative review of 22 recent reports.

Therapeutic use of tranexamic acid (TXA) to minimise blood loss is common during a wide range of surgical procedures. This review aims to explore the clinical features of the accidental intrathecal administration of TXA and to identify contributory factors that might prevent future incidents. The author searched published reports of accidental intrathecal administration of TXA using Medline and Google Scholar databases from July 2018 to September 2022, including error reports in any language but excluding errors via nonintrathecal routes. The human factors analysis classification system (HFACS) framework was used to examine and classify the human and systemic factors that contributed to the errors. Twenty-two errors of accidental intrathecal administration were reported during the search period. The analysis showed that the outcome was death in eight patients (36%) and permanent harm in four (19%). The fatality rate was higher among female individuals (6/13 versus 2/8 male individuals). Two-thirds of errors (15/22) occurred during orthopaedic surgery (10) and lower segment caesarean sections (5). Nineteen of 21 patients developed refractory or super refractory status epilepticus, requiring mechanical ventilation and intensive care for 3 days to 3 weeks for those who survived the initial few hours. Severe sympathetic stimulation resulting in refractory ventricular arrhythmias was the final event in some patients, with death within a few hours. Lack of familiarity with clinical characteristics caused delayed diagnosis or confusion with other clinical conditions. A proposed plan to manage intrathecal TXA toxicity is presented, including immediate cerebrospinal fluid lavage; however, there is no specific approach. The HFACS suggested mistaking look-alike TXA ampoules for local anaesthetic was the predominant cause. The author concludes that inadvertent intrathecal TXA is associated with mortality or permanent harm in more than 50% of patients. The HFACS demonstrates that all errors are preventable.

Health visiting in the UK in light of the COVID-19 pandemic experience (RReHOPE): a realist review protocol

IntroductionHealth visiting services, providing support to under 5s and their families, are organised and delivered in very different ways in different parts of the UK. While there has been attention...

Estimation of Ground Contact Time with Inertial Sensors from the Upper Arm and the Upper Back.

Ground contact time (GCT) is one of the most relevant factors when assessing running performance in sports practice. In recent years, inertial measurement units (IMUs) have been widely used to automatically evaluate GCT, since they can be used in field conditions and are friendly and easy to wear devices. In this paper we describe the results of a systematic search, using the Web of Science, to assess what reliable options are available to GCT estimation using inertial sensors. Our analysis reveals that estimation of GCT from the upper body (upper back and upper arm) has rarely been addressed. Proper estimation of GCT from these locations could permit an extension of the analysis of running performance to the public, where users, especially vocational runners, usually wear pockets that are ideal to hold sensing devices fitted with inertial sensors (or even using their own cell phones for that purpose). Therefore, in the second part of the paper, an experimental study is described. Six subjects, both amateur and semi-elite runners, were recruited for the experiments, and ran on a treadmill at different paces to estimate GCT from inertial sensors placed at the foot (for validation purposes), the upper arm, and upper back. Initial and final foot contact events were identified in these signals to estimate the GCT per step, and compared to times estimated from an optical MOCAP (Optitrack), used as the ground truth. We found an average error in GCT estimation of 0.01 s in absolute value using the foot and the upper back IMU, and of 0.05 s using the upper arm IMU. Limits of agreement (LoA, 1.96 times the standard deviation) were [-0.01 s, 0.04 s], [-0.04 s, 0.02 s], and [0.0 s, 0.1 s] using the sensors on the foot, the upper back, and the upper arm, respectively.

Fragmentation dynamics of electron-impact double ionization of helium

We study the double ionization dynamics of a helium atom impacted by electrons with full-dimensional classical trajectory Monte Carlo simulation. The excess energy is chosen to cover a wide range of values from 5 eV to 1 keV for comparative study. At the lowest excess energy, i.e., close to the double-ionization threshold, it is found that the projectile momentum is totally transferred to the recoil-ion while the residual energy is randomly partitioned among the three outgoing electrons, which are then most probably emitted with an equilateral triangle configuration. Our results agree well with experiments as compared with early quantum-mechanical calculation as well as classical simulation based on a two-dimensional Bohr’s model. Furthermore, by mapping the final momentum vectors event by event into a Dalitz plot, we unambiguously demonstrate that the ergodicity has been reached and thus confirm a long-term scenario conceived by Wannier. The time scale for such few-body thermalization, from the initial nonequilibrium state to the final microcanonical distribution, is only about 100 attoseconds. Finally, we predict that, with the increase of the excess energy, the dominant emission configuration undergoes a transition from equilateral triangle to T-shape and finally to a co-linear mode. The associated signatures of such configuration transition in the electron-ion joint momentum spectrum and triple-electron angular distribution are also demonstrated.

Is to Forgive to Forget? Sovereign Risk in the Aftermath of Private or Official Debt Restructurings

We examine the link between sovereign defaults and credit risk by distinguishing between commercial and official debt and by taking into account the extent of the final restructuring events, which take place at the end of a default spell. We use a local projection-based approach, combined with propensity score weighting (Jordà and Taylor 2016), to estimate the average treatment effect of the final restructuring on our outcome variables of agency ratings and bond yield spreads. Our results show that the average treatment effect on ratings is negative (and positive for bond spreads) up to seven years following the final restructuring with private creditors, while the opposite holds for official creditors. Furthermore, our results are robust to using a panel analysis, which allows us to investigate the importance of the final haircut size. Specifically, we find that the rating (spread) variation (increase) is larger for cases with deeper haircuts. Therefore, we find evidence that official and private defaults have different costs and then may induce selective defaults.

Premessa: Seminario di Studi Dante e il fumetto

The University of Turin has organized a series of events to celebrate the seventh centenary of Dante's death. The final event included a seminar on Dante and comics, a figurative comment which, despite the different purposes and different audiences, still reminds us that Dante's iconic poetry favors illustrations, in which excellent illuminators have distinguished themselves from the very beginning.

Historians and the Decade of Centenaries in Modern Ireland

The Irish ‘Decade of Centenaries’ is, at last, drawing to a close, ending the ‘interminable round of national soul-searching’ which one prominent historian warily anticipated in 2013.1 The final major event to be commemorated is the Civil War of 1922–3, when the Irish republican movement split bitterly and violently over the terms of the treaty granting the southern part of Ireland partial independence from Britain. As it turns out, the government in charge of overseeing that commemoration is a coalition made up of the two principal political parties that emerged from the aftermath of that civil war. Where for a century these parties had formed the binaries of the Irish political division, now their peaceful cooperation in government could be seen as proof of the ‘end of history’, Irish-style. Even erstwhile political enemies – whose ancestors one hundred years ago executed and assassinated each other – could unite in a shared project of ‘inclusive’ and ‘ethical’ commemoration informed by an expert advisory panel made up of prominent academic and public historians. Their unprecedented political cooperation would be encapsulated by the peaceful swapping of the position of Taoiseach (Prime Minister) half-way through the government's term. The third great strand of the Irish Revolution, the labour movement, was fortuitously represented by the election to the Irish Presidency in 2007 of Michael D. Higgins, an academic sociologist and former Labour Party TD (member of parliament). Casann an roth, as Higgins declared in one of his many addresses during the ‘Decade’, as it is colloquially known in Irish history parlance.2 The wheel turns, and this time had come full circle, repairing the fractures in the national movement and restoring national political unity.

Flexible Supervised Autonomy for Exploration in Subterranean Environments

While the capabilities of autonomous systems have been steadily improving in recent years, these systems still struggle to rapidly explore previously unknown environments without the aid of GPS-assisted navigation. The DARPA Subterranean (SubT) Challenge aimed to fast track the development of autonomous exploration systems by evaluating their performance in realworld underground search-and-rescue scenarios. Subterranean environments present a plethora of challenges for robotic systems, such as limited communications, complex topology, visually-degraded sensing, and harsh terrain. The presented solution enables long-term autonomy with minimal human supervision by combining a powerful and independent single-agent autonomy stack, with higher level mission management operating over a flexible mesh network. The autonomy suite deployed on quadruped and wheeled robots was fully independent, freeing the human supervision to loosely supervise the mission, and make high-impact strategic decisions.We also discuss lessons learned from fielding our system at the SubT Final Event, relating to vehicle versatility, system adaptability, and reconfigurable communications.

Peripheral blood cellular profile at pre-lymphodepletion is associated with CD19-targeted CAR-T cell-associated neurotoxicity.

Infusion of second generation autologous CD19-targeted chimeric antigen receptor (CAR) T cells in patients with R/R relapsed/refractory B-cell lymphoma (BCL) is affected by inflammatory complications, such as Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS). Current literature suggests that the immune profile prior to CAR-T infusion modifies the chance to develop ICANS. This is a monocenter prospective study on 53 patients receiving approved CAR T-cell products (29 axi-cel, 24 tisa-cel) for R/R-BCL. Clinical, biochemical, and hematological variables were analyzed at the time of pre-lymphodepletion (pre-LD). In a subset of 21 patients whose fresh peripheral blood sample was available, we performed cytofluorimetric analysis of leukocytes and extracellular vesicles (EVs). Moreover, we assessed a panel of soluble plasma biomarkers (IL-6/IL-10/GDF-15/IL-15/CXCL9/NfL) and microRNAs (miR-146a-5p, miR-21-5p, miR-126-3p, miR-150-5p) which are associated with senescence and inflammation. Multivariate analysis at the pre-LD time-point in the entire cohort (n=53) showed that a lower percentage of CD3+CD8+ lymphocytes (38.6% vs 46.8%, OR=0.937 [95% CI: 0.882-0.996], p=0.035) and higher levels of serum C-reactive protein (CRP, 4.52 mg/dl vs 1.00 mg/dl, OR=7.133 [95% CI: 1.796-28], p=0.005) are associated with ICANS. In the pre-LD samples of 21 patients, a significant increase in the percentage of CD8+CD45RA+CD57+ senescent cells (median % value: 16.50% vs 9.10%, p=0.009) and monocytic-myeloid derived suppressor cells (M-MDSC, median % value: 4.4 vs 1.8, p=0.020) was found in ICANS patients. These latter also showed increased levels of EVs carrying CD14+ and CD45+ myeloid markers, of the myeloid chemokine CXCL-9, as well of the MDSC-secreted cytokine IL-10. Notably, the serum levels of circulating neurofilament light chain, a marker of neuroaxonal injury, were positively correlated with the levels of senescent CD8+ T cells, M-MDSC, IL-10 and CXCL-9. No variation in the levels of the selected miRNAs was observed between ICANS and no-ICANS patients. Our data support the notion that pre-CAR-T systemic inflammation is associated with ICANS. Higher proportion of senescence CD8+ T cells and M-MDSC correlate with early signs of neuroaxonal injury at pre-LD time-point, suggesting that ICANS may be the final event of a process that begins before CAR-T infusion, consequence to patient clinical history.

Inspiring Field Robotics Advances through the Design of the DARPA Subterranean Challenge

As the latest Defense Advanced Research Projects Agency (DARPA) “Grand Challenge,” the Subterranean Challenge was a robotics competition that sought to stimulate innovation and investment in solutions that can rapidly map, navigate, and search complex environments, including human-made tunnel systems, urban underground spaces, and natural cave networks. The program hosted a series of evaluations, namely, three Circuit Events and a Final Event, which assessed each competing team’s approaches in representative subterranean environments. This paper details the careful planning and intentional decisions that went into the design of the competition elements of the Final Event of the DARPA Subterranean Challenge. Intended to offer both insights and motivations, this paper comprehensively describes the official rules, scoring objectives, artifact selection, environment setup, and scenario configurations, all in the context of driving towards advancing key technologies of interest to DARPA and to the field robotics community.

Autonomous Multi-robot Exploration with Ground Vehicles in DARPA Subterranean Challenge Finals

Autonomous navigation and multi-robot exploration framework for ground robots are key parts of the robotic system deployed by the team CTU-CRAS-NORLAB in the final event of the Subterranean (SubT) Challenge organized by the Defense Advanced Research Projects Agency (DARPA) in 2021. The SubT Challenge aimed to advance technologies related to search-and-rescue missions with multi-robot systems in underground environments where communication is unavailable and global navigation satellite systems are denied. This field report describes the developed multi- robot exploration framework focusing on planning, exploration, and traversability estimation for a heterogeneous team of ground vehicles in large-scale rough terrains and multi-robot coordination with limited communication. The developed method employs a dense local mapping for precise traversability estimation combined with a sparse topometrical map shareable between multiple robots and is thus used in the decision-making of the exploration strategy. The topometrical map is designed to support the decentralized coordination of heterogeneous teams of robots, which is demonstrated by deploying the developed framework in the SubT competitions. The framework has been employed in the Virtual track for the full autonomous control of the ground robots, where our team scored second. Besides, in the Systems track, a human supervisor exploited autonomous behaviors provided by the proposed framework to control a heterogeneous team of six ground robots. We report on real-world experimental results from the deployment of the SubT Challenge. Furthermore, we present results from the post-event testing of the SubT Challenge, where three quadruped robots controlled by the framework explored over five hundred meters fully autonomously.

Exploring the Most Sectors at the DARPA Subterranean Challenge Finals

Autonomous robot navigation in austere environments is critical to missions like “search and rescue”, yet it remains difficult to achieve. The recent DARPA Subterranean Challenge (SubT) highlights prominent challenges including GPS-denied navigation through rough terrains, rapid exploration in large-scale three-dimensional (3D) space, and interrobot coordination over unreliable communication. Solving these challenges requires both mechanical resilience and algorithmic intelligence. Here, we present our approach that leverages a fleet of custom-built heterogeneous robots and an autonomy stack for robust navigation in challenging environments. Our approach has demonstrated superior navigation performance in the SubT Final Event, resulting in the fastest traversal and most thorough exploration of the environment, which won the “Most Sectors Explored Award.” This paper details our approach from two aspects: mechanical designs of a marsupial ground-and-aerial system to overcome mobility challenges and autonomy algorithms enabling collective rapid exploration. We also provide lessons learned in the design, development, and deployment of complex but resilient robotic systems to overcome real-world navigation challenges.

Enhanced Deep Learning for Detecting Suspicious Fall Event in Video Data

Suspicious fall events are particularly significant hazards for the safety of patients and elders. Recently, suspicious fall event detection has become a robust research case in real-time monitoring. This paper aims to detect suspicious fall events during video monitoring of multiple people in different moving backgrounds in an indoor environment; it is further proposed to use a deep learning method known as Long Short Term Memory (LSTM) by introducing visual attention-guided mechanism along with a bi-directional LSTM model. This method contributes essential information on the temporal and spatial locations of ‘suspicious fall’ events in learning the video frame in both forward and backward directions. The effective “You only look once V4” (YOLO V4)–a real-time people detection system illustrates the detection of people in videos, followed by a tracking module to get their trajectories. Convolutional Neural Network (CNN) features are extracted for each person tracked through bounding boxes. Subsequently, a visual attention-guided Bi-directional LSTM model is proposed for the final suspicious fall event detection. The proposed method is demonstrated using two different datasets to illustrate the efficiency. The proposed method is evaluated by comparing it with other state-of-the-art methods, showing that it achieves 96.9% accuracy, good performance, and robustness. Hence, it is acceptable to monitor and detect suspicious fall events.

Olimpijski zabavnik

Daily practice shows that educators, teachers, and children find it interesting to jointly organize sports events and competitions that they call "small Olympics, athletic Olympics - in the world of competition and the like". For example, similar to this was the final event of preschoolers in the primary school "Mladost" from Belgrade in June 2023. It is interesting to emphasize that before the new era, the Olympiads represented a unit of measure of 4 years between two Olympic Games. The Summer Olympic and Paralympic Games will be held in Paris in 2024. This paper is intended, primarily for those who are interested in the Olympic Games as the largest sports competition in the world, which is held every four years. In this paper, all members of one family can find something interesting, both the youngest and the oldest. The purpose of this paper is to acquaint readers of different ages with the origin of the Olympic Games, both ancient (Olympia before the new era) and these modern (renewed) ones that were created inspired by the ancient Olympic Games. This paper can serve as a good starting point, primarily for educators, but also for teachers, for planning project and teaching activities on the topic of the Olympic Games, sports competitions, mythology, winter and summer sports, Paralympic competitions, various symbols that are dominant before some planetary events in the near future such as the Olympic Games in Paris in 2024, as well as nations, continents and cities that at least briefly unite the idea of the Olympic Games.