Final Discharge Diagnosis Research Articles

A comparative study between emergency department provisional diagnoses and final discharge diagnoses in tertiary and quaternary health centers of India

An Emergency Department (ED), or the Emergency Room (ER), is a specialized patient care facility in tertiary and quaternary health care centers dedicated to Emergency Medicine. The main function of which, is to take care of patients with immediate and emergent health issues. In view of limited literature on Emergency Medicine in India, a comparative study of the admission and discharge diagnoses was performed, as a baseline for future reference in continuous quality improvement. A scientific endeavor dedicated to undertake a comparative study between the emergency department provisional diagnosis and the final inpatient discharge diagnosis, thus determining the diagnostic accuracy of the emergency medicine department in large health care centers of India. A total of 3000 patients visiting the emergency department were considered and a comparative study was performed between the emergency department diagnoses and the final discharge diagnoses of these patients after admission to respective specialties. In 81% cases the emergency department diagnoses was found to be concordant with the discharge diagnoses of the patients under study, and the concordance was found to be statistically significant. According to our study, the initial diagnoses made by emergency department physicians were mostly consistent with the final diagnoses. The significance of a correct diagnosis in the emergency department is far reaching. A correct diagnosis of the disease in the emergency enables prompt implementation of desired management protocols facilitating better patient outcomes and favorable disease prognosis. However, our study also highlights the need for further improvement in the diagnostic protocols in the emergency department.

Prehospital risk assessment in patients suspected of non-ST-segment elevation acute coronary syndrome: a systematic review and meta-analysis

ObjectiveTo review, inventory and compare available diagnostic tools and investigate which tool has the best performance for prehospital risk assessment in patients suspected of non-ST-segment elevation acute coronary syndrome (NSTE-ACS).MethodsSystematic...

Identification of Stroke and TIA in Patients With Acute Dizziness, Vertigo or Imbalance in Emergency Departments of Primary Care Hospitals: Early Experiences With a Network-Based Telemedical Approach.

BackgroundAcute dizziness, vertigo, and imbalance are frequent and difficult to interpret symptoms in the emergency department (ED). Primary care hospitals often lack the expertise to identify stroke or TIA as underlying causes. A telemedical approach based on telestroke networks may offer adequate diagnostics and treatment.AimThe aim of this study is to evaluate the accuracy of a novel ED algorithm in differentiating between peripheral and central vestibular causes.MethodsWithin the Telemedical Project for Integrative Stroke Care (TEMPiS), a telemedical application including a videooculography (VOG) system was introduced in 2018 in 19 primary care spoke hospitals. An ED triage algorithm was established for all patients with acute dizziness, vertigo, or imbalance of unknown cause (ADVIUC) as a leading complaint. In three predefined months, all ADVIUC cases were prospectively registered and discharge letters analyzed. Accuracy of the ED triage algorithm in differentiation between central and peripheral vestibular cases was analyzed by comparison of ED diagnoses to final discharge diagnoses. The rate of missed strokes was calculated in relation to all cases with a suitable brain imaging. Acceptance of teleconsultants and physicians in spoke hospitals was assessed by surveys.ResultsA total number of 388 ADVIUC cases were collected, with a median of 12 cases per months and hospital (IQR 8–14.5). The most frequent hospital discharge diagnoses are vestibular neuritis (22%), stroke/TIA (18%), benign paroxysmal positioning vertigo (18%), and dizziness due to internal medicine causes (15%). Detection of a central vestibular cause by the ED triage algorithm has a high sensitivity (98.6%), albeit poor specificity (45.9%). One stroke out of 32 verified by brain scan was missed (3.1%). User satisfaction, helpfulness of the project, improvement of care, personal competence, and satisfaction about handling of the VOG systems were rated consistently positive.DiscussionThe concept shows good acceptance for a telemedical and network-based approach to manage ADVIUC cases in the ED of primary care hospitals. Identification of stroke cases is accurate, while specificity needs further improvement. The concept could be a major step toward a broadly available state of the art diagnostics and therapy for patients with ADVIUC in primary care hospitals.

Abstract TP54: Prehospital Stroke Notification: No Record, Didn’t Happen

Introduction: Acute strokes necessitate streamlined communication between first responders and physicians regarding stroke signs ascertained in the field. Stroke alert protocols that dictate hospital resource activation contribute to the speed in which potential cases are assessed and treated. We studied associations between EMS stroke pre-notification and ED stroke alert activation behavior at a Comprehensive Stroke Center. Methods: This retrospective chart review identified patients who arrived via EMS and were ultimately stroke alerted from the ED between April 2020 and July 2021. Data was collected manually through a state-wide EMS record exchange and internal hospital databases to include EMS documentation of attempts to alert the ED to stroke, time of ED stroke alert activation, and final discharge diagnosis. Descriptive statistics are presented as counts and percentages. Results: Among the 472 cases of stroke alerted patients, 214 (45.3%) were discharged with a final diagnosis of acute stroke. There were 167 (35.4%) patients where EMS documented attempts to pre-notify the hospital of a potential stroke, versus 210 (45%) whose records lacked explicit note of pre-notification. EMS records could not be found in 94 (20.2%) cases. Among 167 known cases where EMS attempted hospital pre-notification, the ED activated a stroke alert prior to hospital arrival in 69 (41.3%). Among 210 cases where EMS did not record pre-notification, the ED stroke pre-alerted 23 (11.0%), suggesting gaps in EMS documentation of completed stroke pre-notifications. Of 94 patients who lacked EMS records, 29 (30.9%) were pre-alerted to stroke by the ED. Finally, among 214 patients discharged with acute stroke, 96 (44.9%) had documented EMS stroke pre-notifications, of which 46 (21.5%) received ED pre-alerts. An additional 24 (11.2%) stroke patients who lacked sufficient documentation were stroke alerted by the ED prior to hospital arrival. Conclusions: Quality in communications spanning from EMS to physicians is a crucial prerequisite to timely stroke care. Gaps in EMS records and ED stroke alert activation lend support to a need for standardization in stroke documentation and stroke alert protocols, which may streamline data access and improve patient experience of care.

Abstract TP55: Prehospital Stroke Scale: Classifying The Inconclusive Result

Introduction: The Cincinnati Pre-Hospital Stroke Scale (CPSS) is one of the most utilized, validated tools for stroke assessment by emergency medical services (EMS) providers. While the CPSS was developed to convey that a patient has a positive or negative finding, EMS providers designate some patients with “inconclusive” CPSS. To date, there is no data concerning the clinical presentation or stroke diagnosis of this cohort of patients. Methods: Retrospectively reviewed prehospital electronic medical records from 26 EMS agencies linked with hospital data of patients stroke alerted between April 1, 2020 to July 12, 2021 in our institution. The National Emergency Medical Services Information System Technical Assistance Center (NEMSIS TAC) 2020 Dataset was also evaluated. Data collected included CPSS, EMS chief complaint, EMS primary impression, and final discharge diagnosis. Results: At our institution 362 patients arrived by EMS and were stroke alerted at the hospital, of which 311 patients had a recorded prehospital CPSS. CPSS was recorded as inconclusive in 33.4% (104/311), positive in 52.1% (162/311), and negative in 14.5% (45/311) of patients. Neurological symptoms accounted for 76.9% (80/104) of EMS primary impression for those classified as inconclusive. Sixty percent (48/80) and 18.8% (15/80) of those were stroke-like symptoms and altered mental status, respectively. Stroke/TIA was the discharge diagnosis for 30.8% (32/104) of inconclusive, 63.6% (103/162) of positive, and 37.8% (17/45) of negative CPSSs. Nationally, 7.3% (142,422/1,955,591) of prehospital patients with recorded CPSS had an inconclusive finding. Among patients with primary impression of stroke-like symptoms with recorded prehospital CPSS, 17.3% (21,740/125,581) had an inconclusive label. Conclusion: Inconclusive CPSS designations in the prehospital setting are common. Although these patients present commonly with stroke-like symptoms, they have a low rate of stroke diagnosis. More studies with available prehospital linked hospital data are needed at a national level to understand the inconclusive prehospital CPSS designation and inform proper EMS education on in-practice use of stroke screening tools that reduce the number of inconclusive CPSS.

Differentiating necrotizing soft tissue infections from cellulitis by soft tissue infectious fluid analysis: a pilot study

BackgroundWe conducted this study to evaluate the characteristics of the infectious fluid in soft tissue infection and investigate the utility of the biochemical tests and Gram stain smear of the infectious fluid in distinguishing necrotizing soft tissue infection (NSTI) from cellulitis.MethodsThis retrospective cohort study was conducted in a tertiary care hospital in Taiwan. From April 2019 to October 2020, patients who were clinically suspected of NSTI with infectious fluid accumulation along the deep fascia and received successful ultrasound-guided aspiration were enrolled. Based on the final discharge diagnosis, the patients were divided into NSTI group, which was supported by the surgical pathology report, or cellulitis group. The t test method and Fisher’s exact test were used to compare the difference between two groups. The receiver–operator characteristic (ROC) curves and area under the ROC curve (AUC) were used to evaluate the discriminating ability.ResultsTotal twenty-five patients were enrolled, with 13 patients in NSTI group and 12 patients in cellulitis group. The statistical analysis showed lactate in fluid (AUC = 0.937) and LDH in fluid (AUC = 0.929) had outstanding discrimination. The optimal cut-off value of fluid in lactate was 69.6 mg/dL with corresponding sensitivity of 100% and specificity of 76.9%. The optimal cut-off value of fluid in LDH was 566 U/L with corresponding sensitivity of 83.3% and a specificity of 92.3%. In addition, albumin in fluid (AUC = 0.821), TP in fluid (AUC = 0.878) and pH in fluid (AUC = 0.858) also had excellent diagnostic accuracy for NSTI. The Gram stain smear revealed 50% bacteria present in NSTI group and all the following infectious fluid culture showed bacteria growth.ConclusionsThe analysis of infectious fluid along the deep fascia might provide high diagnostic accuracy to differentiate NSTI from cellulitis.

Thromboelastography Parameters in Urosepsis: A Retrospective Study.

Thromboelastography (TEG) is usually used to monitor coagulation disorder clinically. It is unclear whether TEG has association with urosepsis and sepsis-induced coagulopathy (SIC). The purpose of this study was to investigate the clinical significance of TEG parameters in urosepsis. 90 patients who were admitted to the Emergency Ward and Emergency Intensive Care Unit (EICU) of Ren Ji Hospital affiliated to Shanghai Jiao Tong University School of Medicine due to urinary infection from February 2014 to February 2022 were retrospectively studied. Urosepsis patients and non-sepsis patients were separately investigated according to the final discharge diagnosis and Sepsis 3.0. At the same time, patients with urosepsis were further divided into groups of SIC and non-SIC based on the definition of SIC. The data of clinical features, laboratory biomarkers, and TEG parameters were collected and analyzed. There were significant differences in white blood cell count, C-reactive protein (CRP), platelet count, procalcitonin (PCT), fibrinogen (FIB), international normalized ratio (INR), prothrombin time (PT), D-dimer, and incidence of urinary tract obstruction between the urosepsis group and non-sepsis group (P < 0.05). In the comparison with non-sepsis group, K value was significantly lower (P = 0.006), while α-angle (P = 0.003) and clot index (CI) (P = 0.048) were significantly higher in urosepsis group. The area under the K value curve excluding urosepsis was 0.667. The areas under CI and α-angle curves for diagnosing urosepsis were 0.682 and 0.621, respectively. The patients in SIC group had significantly higher K value, lower α-angle, and maximum amplitude (MA) than those in non-SIC group (P < 0.05). Coagulopathy is prone to occur in patients with urosepsis. TEG is helpful for assessment of hypercoagulable state in urosepsis and prediction of hypocoagulability in SIC patients implying the dynamic process of DIC.

Agreement between Prehospital and Final Diagnosis in Patients with Acute Allergic Reactions: A Cross-Sectional Study

Introduction: Acute allergic reactions are usually first encountered in the prehospital setting and account for about 0.3% to 0.8% of prehospital runs in different countries. Right, and rapid recognition and treatment are necessary to decrease mortality and morbidity, especially in severe critical cases. This study evaluates the accuracy of prehospital care providers’ diagnosis in patients with acute allergic reactions in comparison with final (discharge) diagnosis as the gold standard.&#x0D; Methods: Patients who were transported to 2 urban referral hospitals between 2008 and 2014 under the dispatch code of “acute allergic reaction” were included in the study, retrospectively. Demographic data, etiology of an allergic reaction, clinical presentations, vital signs stability, and need for epinephrine injection were evaluated. The prehospital care providers’ diagnosis (documented on-call report) was compared with the final diagnosis (documented on discharge summary form).&#x0D; Results: A total of 300 patients were included in the study. In 55 (18.3%) cases the prehospital care providers’ and final diagnoses were different. Diagnoses were similar in 245 (81.6%) patients. Kappa coefficient was calculated as 0.621which shows a moderate-to-substantial agreement between prehospital and final diagnoses. Fifteen patients (5%) were discharged from the hospital with a diagnosis of anaphylaxis and only 4 cases (26.6%) were diagnosed in the prehospital setting.&#x0D; Conclusion: Although the overall agreement between prehospital and final diagnosis of acute allergic reactions calculated in this study was good, the accuracy of diagnosing the anaphylaxis (as the most critical allergic reaction with a potential fatality) was less than optimal.

Performance of the RACE Prehospital Triage Score During Working and Nonworking Hours

Background Prehospital triage scores aim to identify large vessel occlusions (LVOs) in the field; however, their real‐world performance and accuracy across a 24‐hour period remains unknown. In this study, we compare the positive predictive value of the prehospital Rapid Arterial occlusion Evaluation (RACE) score for the detection of LVO during working hours and nonworking hours. Methods We performed a retrospective review of all patients presenting with a RACE score of ≥5 at one comprehensive and one thrombectomy‐capable hospital between July 2015 and December 2019. Patients were dichotomized to those presenting during “working hours” (7:00 am to 6:00 pm on weekdays) or “nonworking hours” (6:01 pm to 6:59 am on weekdays or anytime during weekends). The primary outcome was diagnosis of LVO. Secondary outcomes included diagnosis of acute neurovascular syndromes, door‐to‐treatment time metrics, and a modified Rankin Scale of ≤2 in those undergoing mechanical thrombectomy. Results Of the 701 patients with RACE score ≥5, 687 patients were included (355 nonworking hours and 332 working‐hours cohorts). Mean age was 71 and 72 years in the nonworking hours and working hours groups, respectively ( P =0.13). Median National Institutes of Health Stroke Scale and baseline demographics were comparable between the 2 groups. There was no significant difference in the diagnosis of LVO (36.3% versus 34.6%; P =0.69) or final discharge diagnosis. The positive predictive value of the RACE score for the detection of an acute neurovascular syndrome (transient ischemic attack and stroke) was improved during nonworking hours (76.3% versus 67.8%; P =0.01). In patients undergoing mechanical thrombectomy, rates of good clinical outcome were similar (44.7% versus 48%; P =0.76), despite the shorter door‐to‐groin‐puncture and revascularization times during working hours. Conclusions The RACE score shows a consistent positive predictive value in determining LVO during working and nonworking hours. However, it is more accurate in determining acute neurovascular syndromes during nonworking hours, which is driven by a decrease in stroke mimics during this time.

EP.FRI.376 Early Routine CT Scans for All Surgical Admissions for Abdominal Pain May Improve Patient Outcomes

Abstract Aim Acute abdominal pain remains a diagnostic challenge in the Emergency Department (ED) as pathologies can involve various surgical craft groups. Computed tomography (CT) enables accurate diagnosis of abdominal pathologies. However, with pressures on ED such as the “4 hour rule” established by the Australian NSW Health Emergency Performance Plan, there may be resistance or omission of early CT in ED. We hypothesise that early, routine CT in adult patients presenting with acute abdominal pain requiring hospital admission improves patient outcomes by increasing diagnostic and referral accuracy. This study compares the proportion of correct ED diagnosis of abdominal pain presentations with and without formal imaging reports. Methods Data from 118 patients presenting with abdominal pain are collected prospectively in a regional hospital and analysed. Patient demographics, imaging results, initial ED diagnosis and final discharge diagnosis are further examined. Results Out of the 118 patients who had abdominal pain, 32 patients obtained complete imaging with a radiology report whilst 86 patients either did not have any imaging performed or was referred to a general surgical unit prior to obtaining a formal report. Among the patients who had imaging reported, 78% (n = 25/32) had the correct diagnosis, whilst those without a radiology report had a 52% (n = 45/86) diagnostic accuracy. This demonstrates an improved accuracy of diagnosis or reduced error rate of 26% when a scan report is available (p = 0.01). Conclusion Early, routine CT with formal reporting significantly reduces diagnostic error rates and increases accurate referral. This allows accurate diagnosis and improves patient outcomes.

The Diagnosis of Acute Myocarditis in Emergency (DAME) score: improving diagnostics within the emergency department.

Purpose. The final diagnosis of myocarditis is challenging. The aim of our study was to provide the D.A.M.E. (Diagnosis of Acute Myocarditis in Emergency) Score for the fast identification of patients suffering from myocarditis at Emergency Department (ED). Methods. This was a multicenter, retrospective study involving three centers. All medical records from January 2010 to December 2014 reporting a final discharge diagnosis of myocarditis were considered. One hundred-four patients (mean age: 40.2±16.5 years) were enrolled. Clinical, biochemical and instrumental data were gathered. Data were analysed by means of logistic regression model and factorial analysis. A validation cohort from a fourth center was enrolled. Results. The final determinants of the DAME score were six: fever, chest pain, erythrocyte sedimentation rate (ESR) > 20 mm/h, C-reactive protein (hs-CRP) >3 mg/L, troponin serum levels >3 ng/L, and left ventricle ejection fraction < 50%. All of them received a specified score ranging from 0 to 4. A score > 4 was related to 75% probability of myocarditis; a final score ranging between 1 and 4 was related to 57% probability of myocarditis. ROC curve on the validation cohort (289 patients, 27 with myocarditis) demonstrated the best cut-off to be 7: AUC 0.958 (p< 0.001), sensibility: 100%, specificity: 85.11%, PPV: 40.9%, NPV: 100% (LR+: 6.72; LR-: 0.00). Logistic regression analysis revealed Odds Ratio equal to 2.83 (95% CI 1.90 – 4.20, p < 0.0001). Conclusions. DAME score can offer a reliable tool in ED setting for the evaluation of patients suffering from suspected myocarditis.

Comparison of a commercial real-time PCR panel to routine laboratory methods for the diagnosis of meningitis-encephalitis

Meningitis-encephalitis can range from a mild, self limiting illness to a life threatening disease. Rapid microbial diagnosis allows for early targeted management. This study aimed to compare the BioFire FilmArray Meningitis/Encephalitis multiplex PCR panel (ME panel) to traditional testing algorithms for accuracy and turnaround time in the diagnosis of meningitis-encephalitis. From April to November 2018, cerebrospinal fluid (CSF) samples meeting existing laboratory testing criteria for suspected community acquired meningitis-encephalitis were tested on the ME panel and by routine laboratory methods. The methods were compared for accuracy of diagnosis and turnaround time. Where an organism was not identified, the study investigators came to a consensus on whether an infective aetiology was likely based on CSF parameters, clinical features, management and final discharge diagnosis. A total of 147 CSF samples met criteria for testing. Results were concordant in 143 (97%) of cases, including 27 samples where the same organism was identified by both methods. Of the four discordant samples, three organisms identified by the ME panel alone were considered clinically insignificant. One sample, which was culture and antigen positive for Cryptococcus neoformans, was not detected on the ME panel. The ME panel and routine methods identified an organism in 55% and 58% of clinically compatible cases of infection, respectively. The median turnaround time for the ME panel was 2.9 hours, compared to 21.1 hours for routine testing. The ME panel showed high concordance with traditional testing, simplified laboratory workflow, and significantly reduced turnaround time. The failure of the ME panel to detect Cryptococcus spp. is concerning. When cryptococcal meningitis is suspected, we would recommend using culture and cryptococcal antigen testing as the investigations of choice. Despite the availability of molecular assays targeting the common causes of CNS infection, the diagnostic yield remains suboptimal.

Study protocol for a prospective, double-blinded, observational study investigating the diagnostic accuracy of an app-based diagnostic health care application in an emergency room setting: the eRadaR trial

IntroductionOccurrence of inaccurate or delayed diagnoses is a significant concern in patient care, particularly in emergency medicine, where decision making is often constrained by high throughput and inaccurate admission diagnoses....

The diagnostic accuracy of pre-hospital assessment of acute respiratory failure.

Introduction:Acute respiratory failure (ARF) is a common medical emergency. Pre-hospital management includes controlled oxygen therapy, supplemented by specific management options directed at the underlying disease. The aim of the current study was to characterise the accuracy of paramedic diagnostic assessment in acute respiratory failure.Methods:A nested diagnostic accuracy and agreement study comparing pre-hospital clinical impression to the final hospital discharge diagnosis was conducted as part of the ACUTE (Ambulance CPAP: Use, Treatment effect and Economics) trial. Adults with suspected ARF were recruited from the UK West Midlands Ambulance Service. The pre-hospital clinical impression of the recruiting ambulance service clinician was prospectively recorded and compared to the final hospital diagnosis at 30 days. Agreement between pre-hospital and hospital diagnostic assessments was evaluated using raw agreement and Gwets AC1 coefficient.Results:77 participants were included. Chronic obstructive pulmonary disease (32.9%) and lower respiratory tract infection (32.9%) were the most frequently suspected primary pre-hospital diagnoses for ARF, with secondary contributory conditions recorded in 36 patients (46.8%). There was moderate agreement between the primary pre-hospital and hospital diagnoses, with raw agreement of 58.5% and a Gwets AC1 coefficient of 0.56 (95% CI 0.43 to 0.69). In five cases, a non-respiratory final diagnosis was present, including: myocardial infarction, ruptured abdominal aortic aneurysm, liver failure and sepsis.Conclusions:Pre-hospital assessment of ARF is challenging, with limited accuracy compared to the final hospital diagnosis. A syndromic approach, providing general supportive care, rather than a specifically disease-orientated treatment strategy, is likely to be most appropriate for the pre-hospital environment.

Frequency of Thrombotic Events in Hospitalized Patients with Sickle Cell Disease

Background Thrombosis is one of the most common complications described in patients with sickle cell disease. However, little is known about the prevalence, variety and severity of thrombus particularly in sickle cell patients hospitalized with vaso-occlusive crisis. Methods We made a retrospective chart review of patients (age 21 years or older) admitted with sickle cell disease at Hurley Medical Center (Flint, Michigan) and was diagnosed with a thrombotic event between April 2012 and April 2020. To obtain a logistic model, we identified all patients with the the final discharge diagnosis of thrombosis (ICD-9 or ICD-10 code indicating any thrombosis, such as DVT, arterial thrombosis, catheter-related thrombus, pulmonary embolism, and stroke), combined with the diagnosis of sickle cell disease. Findings 37/137 (27%) sickle cell patients were found to have had at least one thrombotic event during their hospitalization. As predicted, patients with sickle cell disease appeared to have very high frequency of thrombotic complications, though we lack a control group to compare with. Genotypes of sickle cell disease was also measured in this study. Patients with the Hb-SS disease had a much higher rate of this complication(25/68=37%) compared with those with Hb SC disease patients (12/49=24%). There were no thrombotic events reported in patients with Hb S/beta thalassemia+, or 0 patients or in patients with Hb SS with HPFH. Interpretation The risk of a thromboembolic event in patients with SCD is high, Sickle cell anemia is a procoagulant condition, which is a risk factor for thrombosis. More research is required to determine if preventive modalities could reduce thrombotic risk. Disclosures No relevant conflicts of interest to declare.

The ESC algorithm for serial high-sensitivity troponin T changes and long-term outcomes in patients with suspected acute coronary syndrome

Abstract Background The fourth universal definition of myocardial infarction (MI) consensus paper suggests that patients with changing troponins not reaching concentrations greater than the 99th percentile may be at high risk and deserve close scrutiny. Purpose To determine long-term prognostic implications of high-sensitivity troponin T (hs-TnT) levels and their relative change (Δ) from baseline in subjects with suspected acute coronary syndrome (ACS). Methods We conducted a retrospective cohort study through individual participant-level linkage between Danish national registries, including subjects with a final discharge diagnosis of acute MI, unstable angina, suspected MI, or chest pain from March 2013 through December 2016 who had a record of at least two serial hs-TnT measurements during hospitalization. Individuals were followed for 12 months, until the occurrence of an event, or censoring due to emigration. Kaplan-Meier analysis and Cox regression, incorporating the competing risk of death, were used to examine the prognostic implications of serial hs-TnT. Subjects were categorized according to whether their first and second hs-TnT were normal/elevated as well as Δhs-TnT and its direction, the latter employing a modified version of the 0/3-hour diagnostic algorithm proposed by ESC, i.e., using cut-offs for Δhs-TnT of 20% and 50%. The primary outcome was a composite of presumed death from cardiovascular causes, recurrent MI, or repeat revascularization (i.e., not including the index event unless the patient died) within 12 months. Results A total of 13,494 individuals (mean age 63.4 years, 39.5% women) were included. Of these, 6129 (45.4%) had a final diagnosis of MI, 941 (7.0%) of unstable angina, and 6414 (47.5%) of either suspected MI or chest pain. Median baseline hs-TnT was 20 ng/l (72.1% elevated), second hs-TnT 27 ng/l (74.6% elevated), Δhs-TnT 4.8%, and time between samples 5.4 hours. At 12 months, 1055 (7.8%) had experienced a primary event. Baseline hs-TnT and Δhs-TnT both displayed a significant association with the primary outcome (P&amp;lt;0.001 for both overall trends and for non-linearity vs. linearity). The Figure shows the prognostic implications of serial hs-TnT. Overall, subjects with two consecutively elevated hs-TnT had the highest 12-month event risk (10.0%), followed by those who went from an elevated to a normal hs-TnT (8.6%), those who went from a normal to an elevated hs-TnT (6.3%), and those with two normal hs-TnT levels (1.6%). The majority either had non-significant Δhs-TnT (−20% to 20%: 56.8%) or a large positive Δhs-TnT (&amp;gt;50%: 30.6%). Individuals with a positive Δhs-TnT (&amp;gt;20%) had a worse prognosis than those without. Conclusions An elevated hs-TnT at any time and Δhs-TnT were both determinants of poorer prognosis in subjects with suspected ACS. Individuals with two normal hs-TnT had a good prognosis, irrespective of their Δhs-TnT. Figure 1 Funding Acknowledgement Type of funding source: None

Serial changes in high-sensitivity troponin I levels indicate poorer prognosis in patients with suspected acute coronary syndrome who fail to reach a level greater than the 99th percentile

Abstract Background According to the fourth universal definition of myocardial infarction (MI) consensus paper, patients with changing troponins who do not reach a concentration greater than the 99th percentile may still be at high risk and should be followed closely. Purpose To determine long-term prognostic implications of high-sensitivity troponin I (hs-TnI) levels and their relative change (Δ) from baseline in subjects with suspected acute coronary syndrome (ACS). Methods We conducted a retrospective cohort study through individual participant-level linkage between Danish national registries. Subjects with a final discharge diagnosis of acute MI, unstable angina, suspected MI, or chest pain from October 2013 through December 2016 who had a record of at least two serial hs-TnI (Dimension Vista®, Siemens Healthineers, Erlangen, Germany; 99th percentile: 45 ng/l) measurements during hospitalization comprised the study population. Kaplan-Meier analysis and multivariable Cox regression, incorporating the competing risk of death, were used to examine the prognostic implications of serial hs-TnI. Subjects were categorized according to whether their first and second hs-TnI were normal/elevated as well as Δhs-TnI and its direction, the latter using cut-offs for Δhs-TnI rises and/or falls of 20% and 50%, extrapolated from the recommendations for troponin T. The primary outcome was a composite of death from cardiovascular causes, recurrent MI, or repeat revascularization (i.e. not including the index event unless the patient died) at 12 months. Results A total of 14,514 individuals (mean age 62.2 years, 46.6% women) were included of whom 3407 (23.5%) had a final diagnosis of MI, 667 (4.6%) of unstable angina, and 10,440 (71.9%) of either suspected MI or chest pain. Median baseline hs-TnI was 15 ng/l (25.3% elevated), second hs-TnI 15 ng/l (29.4% elevated), Δhs-TnI 0%, and time between samples 6.2 hours. At 12 months, 909 (6.3%) first primary events had occurred. Baseline hs-TnI and Δhs-TnI both displayed a significant, non-linear association with the primary outcome (P&amp;lt;0.001). The Figure shows the prognostic implications of serial hs-TnI. Overall, subjects with two consecutively elevated hs-TnI had the highest 12-month event risk (15.7%), followed by those who went from a normal to an elevated hs-TnI (9.9%), those who went from an elevated to a normal hs-TnI (4.2%), and those with two normal hs-TnI (2.7%). Most either had no significant Δhs-TnI (−20% to 20%: 74.9%) or a large positive Δhs-TnI (&amp;gt;50%: 17.5%). Individuals with any Δhs-TnI (&amp;gt;20% in either direction) had a worse prognosis than those without. This was also true for the group of individuals with two normal hs-TnI (event risk 7.8% in those with a Δhs-TnI &amp;gt;20% versus 2.3% in those without, P&amp;lt;0.001). Conclusions Δhs-TnI was an important determinant of poorer prognosis in subjects with suspected ACS, even among individuals who did not reach a concentration greater than the 99th percentile. Figure 1 Funding Acknowledgement Type of funding source: None

371 Ovarian Torsion versus Ruptured Ovarian Cyst: Emergency Department Presentation and Outcomes

As the fifth most common gynecologic surgical emergency, ovarian torsion is a diagnosis that emergency physicians need to consider, as early diagnosis is key to restore blood flow to the ovary and avoid permanent damage. Ruptured ovarian cysts can present similarly with sharp, sudden onset of pelvic pain. This can result in difficulty distinguishing between ovarian torsion and ruptured ovarian cyst on history and physical exam. This study will evaluate similarities and differences in clinical presentation or outcomes of patients presenting to ED with ovarian torsion or ruptured ovarian cyst. This five-year retrospective study at two community teaching EDs includes all patients with a chief complaint of abdominal pain and a primary final discharge diagnosis of ovarian torsion or ruptured ovarian cyst. Excluded are pregnant patients and patients with no imaging studies in the ED. Descriptive statistics are reported as medians or percentage and statistical testing done with either Mann-Whitney or Fisher Exact as appropriate. Significance was set at p=0.05. 91 cases meet inclusion/exclusion criteria; 26 (28.6%) had ovarian torsion while 65 (71.4%) had ruptured ovarian cyst. The initial vital signs were all unremarkable. No one was febrile, the highest heart rate was 105 and there was only one hypotension (84/53). 78.0% (71/91) had ultrasound studies while in the ED, 53.8% (49/91) had CT abdominal scans, and 33.0% (30/91) had both done while in the ED. Patients with ovarian torsion were significantly older (34.5 years versus 27.0; p<0.001). However, there were no differences in time from pain onset, days from last menstrual period, history of vaginal bleeding, or prior history of ovarian cysts. All of the torsion patients were admitted to the hospital and 88.3% had surgery, while 13.8% of ruptured cysts were admitted and 9.2% had surgery. In this five-year retrospective study, aside from slight age differences, there were no differences in the clinical presentation of patients with ovarian torsion or ovarian cyst rupture. However, 88.3% of patients with torsion required emergent surgical intervention while only 13.8% of ruptured ovarian cyst required surgical intervention. As there are no distinguishing characteristics between ovarian torsion and cyst rupture, suspected patients should have expeditious and appropriate imaging studies while in the ED.

Efficacy of Chest CT for COVID-19 Pneumonia Diagnosis in France.

BackgroundThe role and performance of chest CT in the diagnosis of the coronavirus disease 2019 (COVID-19) pandemic remains under active investigation.PurposeTo evaluate the French national experience using Chest CT for COVID-19, results of chest CT and RT-PCR were compared together and with the final discharge diagnosis used as reference standard.Materials and MethodsA structured CT scan survey (NCT04339686) was sent to 26 hospital radiology departments in France between March 2 and April 24 2020. These dates correspond to the peak of the national COVID-19 epidemic. Radiology departments were selected to reflect the estimated geographical prevalence heterogeneities of the epidemic. All symptomatic patients suspected of having a COVID-19 pneumonia who underwent within 48 hours both initial chest CT and at least one RT-PCR testing were included. The final discharge diagnosis, based on multiparametric items, was recorded. Data for each center were prospectively collected and gathered each week. Test efficacy was determined by using Mann-Whitney Test, Student’s t-test, Chi-square test and Pearson’s correlation. A p value <.05 determined statistical significance.ResultsTwenty-six of 26 hospital radiology departments responded to the survey with 7500 patients entered; 2652 did not have RT-PCR results or had unknown or excess delay between RT-PCR and CT. After exclusions, 4824 patients (mean age 64, ± 19 yrs, 2669 males) were included. Using final diagnosis as the reference, 2564 of the 4824 patients were positive for COVID-19 (53%). Sensitivity, specificity, NPV and PPV of chest CT for diagnosing COVID-19 were 2319/2564 (90%, 95% confidence interval [CI]: 89, 91), 2056/2260 (91%, 95%CI: 91, 92%), 2056/2300 (89%, 95%CI; 87, 90%) and 2319/2524 (92%, 95%CI 91, 93%) respectively. There was no significant difference for chest CT efficacy among the 26 geographically separate sites, each with varying amounts of disease prevalence.ConclusionUse of chest CT for the initial diagnosis and triage of suspected COVID-19 patients was successful.

Abstract TP289: Diagnostic Evaluation of Patients Admitted to Emergency Department Observation Unit for Suspected TIA

Introduction: Emergency department observation units (ED-OU) allow patients with a suspected transient ischemic attack (TIA) an expedited workup without the need for a prolonged inpatient admission. Despite risk stratification scores and physician evaluation, however, the reliability in diagnosis of TIA remains poor, which may lead to unnecessary testing. This study aimed to identify and compare the diagnostic workup between patients with final diagnosis of true vascular events (TIA or minor stroke, TIAMS) versus nonischemic transient neurological attacks (NI-TNA) in suspected TIA patients admitted to an ED observation unit. Methods: A retrospective analysis was performed on consecutive patients who were admitted to an ED-OU at a single center for suspected TIA. All diagnostic testing obtained during observation stay was abstracted from chart review. Final discharge diagnosis was dichotomized to either TIAMS or NI-TNA. Standard statistical tests were used for comparison testing between the two groups with significance defined as p&lt;0.05. Results: Of 186 suspected TIA patients admitted to an ED-OU, median ABCD2 score was 4 [IQR 3-4]. Final diagnosis was TIAMS in 85 (46%) patients and NI-TNA in 101 (54%) patients. A total of 182 (98%) patients had non-contrast head CT (NCHCT); 160 (86%) brain MRI; 117 (63%) extracranial vessel imaging; 116 (62%) transthoracic echocardiogram (TTE); and 108 (58%) intracranial vessel imaging. Assessing diagnostic work-up by final diagnosis, TTE (78% vs 40%, p&lt;0.01), and extracranial imaging (75% vs 55%, p&lt;0.01) were more common in patients with TIAMS. Restricted diffusion on MRI (27% vs. 2%, p&lt;0.01) and abnormality on TTE (50% vs. 28% p=0.02) were more common in TIAMS patients. The overall rate of symptomatic stenosis was low: 1 patient had a symptomatic carotid and 4 patients had symptomatic intracranial stenosis. Conclusion: Extensive diagnostic testing is done on patients with suspected TIA admitted to ED-OU, with more studies acquired on patients with true ischemic events as compared to NI-TNA. As the use of ED-OUs increases, refinement of current diagnostic testing algorithms to reduce workup for cerebrovascular disease among patients with NI-TIA and among different ischemic stroke subtypes is warranted.