Objectives: To develop a Stroke Inpatient Rehabilitation Care Pathway that assists health care professionals with clinical decision making and goal setting, and to organize patient care for optimal outcomes. Design: Prospective review. Setting: Not provided. Participants: Not provided. Interventions: Not applicable. Main Outcome Measures: Objective assessments include the FIM instrument change, FIM efficiency, discharge locations, and patient satisfaction measures. Follow-up measures at 3 months postdischarge evaluated sustained outcomes. Results: Clinical outcomes are better in stroke rehabilitation units because of greater adherence to care processes. The pathway is divided into 3 phases. The first phase (within 48h) requires rapid assessment of the patient by all practitioners involved in care. The second phase (days 2 through 7) includes a multidisciplinary team conference, goal development, identification and training of care providers, and patient training in disease management (eg, hypertension, anticoagulation, diabetes). The last phase (day 8 or until discharge) addresses discharge criteria, including bowel and bladder management, identifying community support, obtaining needed equipment, caregiver and family education, determining ongoing medical care, and arranging any further needed rehabilitation services. Conclusions: The Stroke Inpatient Rehabilitation Care Pathway assists in efficient utilization of multiple medical rehabilitation services for the sustained benefit of stroke survivors.