The selection of an appropriate fabric for technical applications, such as protective masks, hinges on a thorough understanding of the fabric's physical and mechanical properties. This study addresses the challenge of selecting the optimal material structure for the upper layer of a protective mask, aiming to ensure adequate breathability while providing effective filtration against airborne particles and contaminants. We assessed and compared the physical-mechanical properties of five polymer spun-bond nonwoven fabrics from different suppliers. Our comprehensive evaluation included, as follows: a visual inspection; light permeability analysis; mass and thickness measurements; elongation and tensile strength tests; breathing resistance assessments; and filter penetration tests with paraffin oil. The results revealed significant variations in performance among the samples, with one fabric consistently outperforming the others across multiple parameters. Notably, this top-performing fabric met or exceeded the EN 149:2001+A1:2009 standard for breathing resistance and filtration efficiency and, in combination with additional filter layers, met the requirements or exceeded class FFP2 (filtering face piece). This study underscores the importance of meticulous material selection and quality control in optimizing PPE (personal protective equipment) performance and user safety, providing valuable insights for mask manufacturers and healthcare professionals.