Abstract Background: In pregnancy, hematological changes occur in order to meet the demands of the developing fetus and placenta, with major alterations in blood volume. Abnormal hematological profile affects pregnancy and its outcome. Objective: The objective of study is to determine the hematological changes that take place during pregnancy, to assess these changes in pregnant women, and to contrast hematological parameters between trimesters in Duhok Governorate, Iraq. Materials and Methods: From October 2021 to May 2022, at the Duhok Maternity Hospital, 210 (70 first, 70 s, and 70 third trimesters) consecutively healthy pregnant women were subjected to the study. A pre-tested questionnaire form used to gather socio-demographic data for hematological parameters analysis using a Medonic auto analyzer blood count coulter, and a peripheral blood film review, after the withdrawal of four milliliters of blood from voluntaries participants. Results: The hematological profile for 210 pregnant women was studied, and there were differences between the trimesters. The results for red blood cells, hematocrit, mean corpuscular hemoglobin concentration and lymphocytes were found statistically significant between 1st and 2nd trimesters (P value = 0.020, 0.0001, 0.006, and 0.023), respectively. Furthermore, the mean and standard deviation of lymphocytes between 1st and 3rd trimesters were statistically significant (P value < 0.05). A significant difference was found between 2nd and 3rd trimester for hemoglobin and platelets (P value 0.0001 and 0.021), respectively. Conclusion: Numerous hematologic problems can be brought on by being pregnant or develop during pregnancy. These hematological conditions were leukocytosis, anemia, and thrombocytopenia. These complaints are a generous cause of morbidity and mortality in pregnant women, which has effects on both the mother and the fetus. In order to reduce the hazards, these hematological illnesses provide to pregnant women and their developing fetus; more research should be done.
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