Filariasis Endemic Area Research Articles

Risk Factors for Lymphatic Filariasis in Endemic Areas of Papua Using Binary Logistic Regression Based on Synthetic Minority Over-sampling Technique

Risk Factors for Lymphatic Filariasis in Endemic Areas of Papua Using Binary Logistic Regression Based on Synthetic Minority Over-sampling Technique

Ocular Brugia pahangi Filariasis Complicated by Severe Macular Damage in Thailand: Case Report and Literature Review.

Extralymphatic filariasis caused by filaria of zoonotic origins has been frequently reported in Thailand over recent years. Here, we report the first case of ocular filariasis in a 7.5-year-old Thai boy who initially presented with progressive conjunctival redness and blurred vision in his right eye. A small, slender, coiled worm was found and surgically removed from the right anterior chamber. Histopathological examination illustrated predominant eosinophilic inflammation surrounding the parasite, which showed smooth and thin cuticle, prominent lateral chords, flat and broad muscle cells, one intestine, and two reproductive tubes with unsegmented ova, typically characteristic of a female adult Brugia filarial nematode. The parasite was also molecularly identified as B. pahangi, based on mitochondrial cytochrome c oxidase subunit I sequence analysis. The patient was then empirically prescribed albendazole, systemic prednisolone, and topical methylprednisolone. Unfortunately, his vision did not recover after 2 months due to severe maculopathy, most likely resulting from parasitic infestation and subsequent vitreous inflammation. To the best of our knowledge, this is the first case of ocular infestation by B. pahangi with visual complications that occurred outside a filariasis-endemic area of Thailand. Furthermore, this report provides clinical data on preceding cases of B. pahangi filariasis formally reported in southeast Asian countries, including Thailand and Malaysia, which facilitate a better understanding of the epidemiology of this sporadic zoonotic infection for effective disease elimination.

Upaya peningkatan pengetahuan masyarakat tentang penyakit filariasis di Desa Kemingking Dalam Kecamatan Taman Rajo

ProvinceJambi is one of the filariasis endemic areas. Almost all regencies / cities in Jambi Province have filariasis cases. Cumulatively the number of chronic filariasis cases reported in Jambi Province in 2014 was 375 cases spread across 9 Regencies / Cities with the highest cases in Muaro Jambi District. Based on the results of the 2014 Finger Blood Survey (SDJ), 180 cases of filariasis in Muaro Jambi District were scattered in 13 health centers in 8 sub-districts of 11 sub-districts. With the discovery of new cases as many as 9 cases. And the most cases were in the MuroKumpeh Health Center area of ​​50 cases. Community service activities are carried out with counseling methods and demonstrations related to filariasis and methods of prevention. From the results of the survey it is known that Muaro Jambi Regency is still an endemic filariasis area with an Mf rate of 1.8%. There was an increase in the average knowledge of the community from before and after the socialization of filariasis in the village of KemingkingDalam.

Epidemiological Assessment of Lymphatic Filariasis in Pekalongan City, Central Java, Indonesia

Lymphatic filariasis is an infectious disease caused by filarial worms and transmitted by mosquitoes. Pekalongan City is the highest filariasis endemic area caused by Wuchereria bancrofti in Central Java. This is indicated by the microfilaria rate of 2.8% in 2016. To reduce the number of filariasis cases, mass drug administration has been carried out since 2011. The aim of the study was to describe the epidemiology of the distribution of filariasis endemic areas, microfilaria rate, treatment coverage. mass and the correlation of sociodemographic factors with the incidence of filariasis. The research variables used secondary data in the form of filariasis cases, education, population density, gender and land use. Data analysis used Spearman's correlation. The results showed that cases of filariasis were spread across all districts with an increasing number of endemic areas during 2011-2016. Efforts to mass treatment have not been successful (mf rate > 1% and treatment coverage < 65%) and must be repeated in 2017-2019. Sociodemographic factors were not related to the incidence of clinical or chronic cases of filariasis. To accelerate the achievement of filariasis elimination, it is necessary to add vector control efforts in integrated filariasis management.

Mass drug administration for lymphatic filariasis elimination amidst COVID-19 pandemic in Odisha, India: A step towards achieving SDG-3.

Sustainable Development Goal-3 (SDG) aims to eliminate lymphatic filariasis by 2030 through >65% coverage and compliance of mass drug administration (MDA), the preventive chemotherapy strategy of delivering anthelminthic drugs. However, the ongoing COVID-19 pandemic has disrupted such programmes, yet MDA was administered during February 2021 in Odisha, India. We aimed to assess the coverage and compliance of the present round of MDA amidst the pandemic and explore factors for non-compliance in Cuttack district of Odisha, a filariasis endemic area. Community-based participants enrolled through multistage stratified sampling were administered a semi-structured questionnaire following COVID-19 protocols. The coverage of MDA was 93.2% whereas consumption was 73.7%. Participants reported that healthcare workers were motivated and satisfactorily explained the benefits of MDA but still fear of side-effects was the major cause of non-compliance. Nonetheless, this recent round of MDA was effective, despite challenges posed by the ongoing pandemic.

Canine filaria species in selected lymphatic filariasis endemic and non-endemic areas in Sri Lanka.

Subperiodic brugian filariasis and dirofilariasis show a rising trend in Sri Lanka posing a threat to public health. As information was limited on canine filaria species in Sri Lanka, we studied the filaria parasites among dog populations in lymphatic filariasis (LF) endemic and non-endemic regions by microscopy and molecular methods. Thick blood smears (TBSs) were performed among 295 dogs presenting to veterinary clinics for surgical or sterilization procedures in Galle (LF endemic) and Mullaitivu (LF non-endemic) districts, of which 55.6% were positive for any microfilariae. We identified Dirofilaria repens (50.8%) and Brugia spp. (20.6%) by microscopy, which, included mono-infections (D. repens 35.3% and Brugia spp. 5%) and co-infections (15.6%). Infections in Galle and Mullaitivu were 61% and 44.9% respectively. The brugian filariasis rate was significantly higher among canines in LF endemic Galle district (29.9%) than in Mullaitivu (LF non-endemic) (1.1%) (P < 0.001), while D. repens infections were comparable in both districts. Genomic DNA extracted from 10% of microfilariae positive TBSs was amplified using pan-filarial primers targeting the internal-transcriber-spacer region-2 (ITS-2). Sequencing of amplicons confirmed the presence of D. repens (89.28%), Brugia pahangi (7.14%) and B. malayi (3.57%) infections. The phylogeny constructed and analysed in MEGA X indicated genetic variability among D. repens and B. pahangi isolates from Sri Lanka. With this study, we were able to report B. pahangi infections for the first time in Sri Lanka.

Bionomics study of Mansonia (Diptera: Culicidae) in a filariasis-endemic area of Sedang Village, Banyuasin Regency, South Sumatra, Indonesia

An investigation of bionomic study of Mansonia species was successfully conducted in Sedang village which is one of the filariasis-endemic areas in Indonesia. The study was carried out for 14 months from April 2017 to May 2018. In order to trap the local mosquitoes in the study area, indoor and outdoor human landing collection method was adopted. During the study, 7,908 mosquitoes were collected which consisted of 13 genera and 40 species of mosquitoes. Moreover, Mansonia uniformis, M. annulifera, and M. indiana were found to be the most abundant, dominant, and high frequency mosquitoes. The filariasis vector analysis through polymerase chain reaction test confirmed that only Mansonia annulifera positively detected as the filariasis vector. Furthermore, the longevity calculation showed that 81% of all the collected Mansonia spp. had already oviposited their eggs which indicates that the studied area possesses high possibilities of filariasis transmission.

Diversity, domination and behavior of mosquitoes in filariasis endemic area of Bogor District, West Java, Indonesia

Abstract. Nirwan M, Hadi UK, Soviana S, Satrija F, Setiyaningsih S. 2022. Diversity, domination and behavior of mosquitoes in filariasis endemic area of Bogor District, West Java, Indonesia. Biodiversitas 23: 2093-2100. A study on the diversity, dominance and behavior of mosquitoes was done in the two filariasis endemic areas in Bogor District, West Java, Indonesia. The objectives of this study were to determine the diversity, dominance and behavior of mosquitoes and their importance as vectors of filariasis in two endemic areas in Bogor District, namely Tamansari Village (rural) and Cimanggis Village (urban). This research was carried out from September 2019 to February 2020. Mosquitoes were collected from 6.00 pm to 6.00 am, twice a month in each village, by using the bare leg collection technique. The collected mosquitoes were identified and analyzed. Filaria detection was carried out by dissecting technique and polymerase chain reaction (PCR). The result indicated eight (8) species of mosquitoes in the rural area (Tamansari village), i.e., Culex quinquefasciatus, Aedes aegypti, Cx. vishnui, Cx. tritaeniorhynchus, Armigeres kesseli, Ar. subalbatus, Ae. albopictus, Mansonia annulata. On the other hand, there were six (6) species found in the urban area (Cimanggis village), i.e., Cx. quinquefasciatus, Ae. aegypti, Ar. kesseli, Ar. subalbatus, Cx. vishnui, Cx. tritaeniorhynchus and Cx. quinquefasciatus were found to be the most dominant in Tamansari village (90.46) and also in Cimanggis Village (95.67). Based on the analysis showed that the mosquito diversity index was low in both the Tamansari village (H’: 0.444) and the Cimanggis village (H’: 0.238). In general, mosquito-biting behavior prefers to suck blood indoors (anthropophilic) with a peak density in the range of 23.00-04.00. The results of filarial detection using dissecting technique and PCR methods against mosquitoes caught in Tamansari Village and Cimanggis Village did not find any L3 larvae and microfilariae in the examined mosquitoes. Culex quinquefasciatus was found to be very potential as the main vector for the spread of filariasis both in rural and urban areas of endemic filariasis of Bogor District, Indonesia.

Role of cytology in diagnosis of filariasis in clinically unsuspected cases: A study from an endemic area of Western Uttar Pradesh in India.

Filariasis is a global health problem. Lymphatic filariasis is the second most common vector-borne disease in India and is a major contributor to chronic deformity like elephantiasis. The disease is widespread in India and highly endemic zones are present in several states, particularly Uttar Pradesh, Bihar, Orissa, Jharkhand and Andhra Pradesh. Filariasis can rarely present as asymptomatic swellings in various unusual sites in the body and very uncommonly as a sole finding in effusion cytology. Cytology plays a very crucial role in incidental diagnosis of filariasis in clinically unsuspected cases. The purpose of this study is to analyze the role of cytology in diagnosis of filariasis, especially in clinically unsuspected cases and to study the cytological findings associated with filariasis in these cases . The present observational descriptive study was conducted in a tertiary care hospital of this region. We collected the cases for this study from our routine cytology cases (FNAC/Body fluids) of over a three years period from March’2017 to March’2020 . All the diagnosed cases of filariasis in cytology were then evaluated by two pathologists. Aspiration was done using 23 G needle attached to a 10/20 cc syringe. Descriptive statistical analysis was done wherever required.Nine cases of filariasis were diagnosed in routine cytology smears (FNAC/Body fluids) during our three years study period. Conclusion: Cytology plays a very crucial role in diagnosis of filariasis in endemic areas, especially in those with atypical presentations. Therefore meticulous screening of all cytology smears is strongly indicated. Key Words: Filariasis, Cytology, Incidental diagnosis, Endemic area

Characteristic differences between breeding places with and without Culex sp. larvae on lymphatic filariasis patient surroundings in an endemic area

Brebes Regency is one of the Lymphatic Filariasis (LF) endemic areas in Central Java Province, Indonesia. Ketanggungan Subdistrict, Bantarkawung Subdistrict and Paguyangan Subdistrict have the highest case numbers. Culex sp. is one of the vectors of LF in Java, Indonesia. This study was conducted to obtain information about the characteristics of the breeding places for Culex sp. in the area where people with LF live. The finding could be used as information with facts for society. It was a descriptive quantitative study with an observational design. The observation was conducted in a radius of 200 meters around the settlements of LF (15 patients) in three sub-districts in the Brebes Regency. Observed and measured data were larval density, water acidity, air temperature, air humidity, water flow, prominent flora presence, and prominent fauna presence. The breeding places observed were puddles, rivers, and sewers. Puddles and sewers with no aquatic animals were observed positively for the presence of Culex sp. larvae. The most preferred breeding place for Culex sp. in the study area were uncovered sewers.

Investigating immunological interaction between lymphatic filariasis and COVID-19 infection: a preliminary evidence

ABSTRACT The foremost concerns of COVID-19 vaccines are safety and efficacy, which becomes grave in countries with a high burden of Neglected Tropical Diseases. Studies proposed helminthic infections might alleviate the efficacy of COVID-19 vaccines. We share preliminary evidence on the association between filariasis and COVID-19 infection. We collated 2 ml of blood from 174 participants residing in filariasis endemic area. To determine filarial antigen, the Og4C3 test and for COVID-19 antibodies, tests through ELISA was performed. COVID-19 antibodies were present among 74/174 (42.5%), whereas filarial antigens were detected in 24/174 (13.8%) participants. An insignificant association [OR = 0.855 (0.36–2.034)] between two was observed. Hence, people in filarial endemic regions can continue taking vaccines without worrying about their efficacy due to the helminthic load in community.

A miniPCR-Duplex Lateral Flow Dipstick Platform for Rapid and Visual Diagnosis of Lymphatic Filariae Infection.

Lymphatic filariasis (LF) is a neglected major tropical disease that is a leading cause of permanent and long-term disability worldwide. Significant progress made by the Global Programme to Eliminate Lymphatic Filariasis (GPELF) has led to a substantial decrease in the levels of infection. In this limitation, DNA detection of lymphatic filariae could be useful due to it capable of detecting low level of the parasites. In the present study, we developed a diagnostic assay that combines a miniPCR with a duplex lateral flow dipstick (DLFD). The PCR primers were designed based on the HhaI and SspI repetitive noncoding DNA sequences of Brugia malayi and Wuchereria bancrofti, respectively. The limits of detection and crossreactivity of the assay were evaluated. In addition, blood samples were provided by Thais living in a brugian filariasis endemic area. The miniPCR-DLFD assay exhibited a detection limit of 2 and 4 mf per milliliter (mL) of blood for B. malayi as well as W. bancrofti, respectively, and crossamplification was not observed with 11 other parasites. The result obtained from the present study was in accordance with the thick blood smear staining for the known cases. Thus, a miniPCR-DLFD is an alternative tool for the diagnosis of LF in point-of-collection settings with a modest cost (~USD 5) per sample.

Nocturnal Activity of Aedes spp. in the Filariasis Endemic Area in Central Java

Program eliminasi filariasis belum menunjukkan hasil maksimal di Provinsi Jawa Tengah. Perubahan perilaku vektor nyamuk terutama waktu aktif menghisap darah sangat mempengaruhi penularan penyakit filariasis. Salah satu perubahan perilaku vektor tersebut adalah aktivitas nyamuk Aedes spp. yang aktif di pagi hari menjadi aktif di malam hari. Tujuan penelitian ini adalah untuk mendeskripsikan aktivitas nokturnal nyamuk Aedes spp. di daerah endemis filariasis di Jawa Tengah. Penelitian ini merupakan penelitian observasional dengan desain cross-sectional yang dilakukan di dua desa endemis filariasis yaitu Desa Tegal Dowo, Kecamatan Tirto, Kabupaten Pekalongan dan Desa Ujung-Ujung, Kecamatan Pabelan, Kabupaten Semarang. Penangkapan nyamuk dilakukan selama 2 malam di rumah penderita filariasis atau rumah di sekitar rumah kasus (Jarak ± 200 meter) dengan menggunakan teknik purposive sampling. Penangkapan nyamuk berlangsung pada pukul 18.00 - 24.00 WIB dengan jumlah penangkap nyamuk 3 orang di dalam dan 3 orang di luar rumah. Pengumpulan nyamuk dilakukan dengan metode Human Landing Collection (HLC) dan resting collection. Hasil penelitian menunjukkan peningkatan aktivitas nokturnal Aedes aegypti dan Aedes albopictus di daerah endemis filariasis di Jawa Tengah. Total nyamuk Aedes spp. yang ditemukan yaitu sebanyak 124 nyamuk, dengan 121 Ae. aegypti ditemukan di dalam rumah dan 2 nyamuk diluar rumah. Di dua wilayah penelitian ditemukan waktu aktif Ae. aegypti berada pada pukul 18.00-19.00 WIB. Hasil penelitian ini menunjukkan adanya aktivitas nokturnal dari Aedes spp. di wilayah endemis Filariasis di Provinsi Jawa Tengah

Low Knowledge and Lack of Awareness Regarding the Mass Drug Administration Health Promotion as the Determinant Factors in Non-Compliance to the Mass Drug Administration Health Program

From the total population of the community in Kuningan District, 78.61% were taking filariasis drugs in the Mass Drug Administration (MDA) program in 2017. Cilimus Subdistrict became a filariasis-endemic area in Kuningan with 72.39% of the MDA program coverage in 2017 (government target &gt;86%). The purpose of this study was to analyze the determinant factors of compliance with the MDA program. The study was an analytical study with a cross-sectional design and conducted from May to June 2018. The sample of 106 people was taken from the population living in Cilimus Subdistrict, Kuningan District, using a simple random sampling technique. Independent variables were collected by a constructed questionnaire included age, education level, knowledge, attitude, health promotion, and family support. A questionnaire also measured compliance with MDA as a dependent variable. Data analysis consisted of univariate, bivariate (chi-square and Fisher exact test), and multivariate analyses (multiple logistic regression). The results showed that the variables of knowledge, attitude, MDA health promotion, and family support influence compliance with the MDA (p-value &lt; 0.05). Low knowledge and unawareness of the MDA health promotion proved to be the dominant factors in non-compliance with the MDA program.

Economic Costs and Benefits of Community-Based Lymphedema-Management Programs for Lymphatic Filariasis in India.

.Lymphatic filariasis (LF) is endemic in 72 countries; 15 million persons live with chronic filarial lymphedema. It can be a disabling condition, frequently painful, leading to reduced mobility, social exclusion, and depression. The Global Program to Eliminate Lymphatic Filariasis aims to stop new infections and care for affected persons, but morbidity management has been initiated in only 38 countries. We examine economic costs and benefits of alleviating chronic lymphedema and its effects through simple limb care. We use economic and epidemiological data from 12 Indian states in which 99% of Indians with filariasis reside. Using census data, we calculate the age distribution of filarial lymphedema and predict the burden of morbidity of infected persons. We estimate lifetime medical costs and lost earnings due to lymphedema and acute dermatolymphangioadenitis (ADLA) with and without community-based limb-care programs. Programs of community-based limb care in all Indian endemic areas would reduce costs of disability by 52%, saving a per person average of US$2,721, equivalent to 703 workdays. Per-person savings are 185 times the program’s per-person cost. Chronic lymphedema and ADLA impose a substantial physical and economic burden in filariasis-endemic areas. Low-cost programs for lymphedema management based on limb washing and topical medication are effective in reducing the number of ADLA episodes and stopping progression of disabling lymphedema. With reduced disability, people can work longer hours per day, more days per year, and in more strenuous, higher paying jobs, resulting in important economic benefits to themselves, their families, and their communities.

Filariasis Vulnerability Zonation Based on Environmental and Behavioural Aspects in Pekalongan City, Indonesia

Pekalongan City is a filariasis endemic area in Central Java, Indonesia with Mf-rate >1%. It had held Mass Drug Administration (MDA) in 2011-2015. The evaluation result recommended it to re-hold MDA. This study aimed to compose filariasis vulnerability zonation based on environmental and behavioural aspects in Pekalongan City. The observed environmental aspects were the location of shrubs, cattle pen and tidal flood. The surveyed behavioural aspects were applicating mosquito repellent and hanging clothes habits. Filariasis cases data were collected from health office. This was a descriptive quantitative study with spatial approach. The environmental and behavioural aspects were observed and surveyed in 6 urban villages (38 RWs) with 387 households as samples which were chosen with proportional random sampling. The instruments were checklist sheets, Global Positioning System (GPS), satellite imagery and GIS software. Data were analysed with scoring, buffering and overlaying procedures. Results indicated some areas were categorized as highly vulnerable where shrubs, cattle pen, tidal flood and hanging clothes habit were present. It was concluded that all urban villages in this study had highly vulnerable RWs which are very potential for filariasis transmission. Applicating mosquito repellent habit was not potential aspect for controlling filariasis transmission in the studied areas.

Diversity and Activities of Mosquito in Yogyakarta Special Region Province, Indonesia, a Non Filariasis Endemic Area

According to data from the Ministry of Health of the Republic of Indonesia in 2018, there were 37 cases of Elephantiasis in Yogyakarta, even though Yogyakarta is not an endemic area of filariasis. This preliminary study was carried out to evaluate the diversity of species, relative abundance, frequency and dominance of mosquitoes in Yogyakarta and to determine the role of mosquitoes as a vector of filariasis. A cross-sectional study was used involving 3 hamlets with elephantiasis cases found in April 2019 in Yogyakarta. Mosquitoes around the house inhabited by the patient with elephantiasis were collected for 12 hours starting from 6:00 p.m. until 6:00 a.m. Mosquitoes were dissected under a dissection microscope and the presence of filaria larvae was observed. A total of 9 mosquitoes species were found. They were Culex vishnui, Culex tritaenorhynchus, Armigeres kesseli, Aedes albopictus, Culex quinquefasciatus, Culex bitaenorhynchus, Anopheles vagus, Anopheles subpictus, Aedes aegypti. The highest diversity, frequency, and dominance was Culex vishnui, while the lowest was Culex quinquefasciatus. There was no filarial larva found during the study.

Penemuan Mikrofilaria Brugia malayi di Wilayah yang Telah Lulus Transmission Assesment Survey (TAS-3) di Kabupaten Kotawaringin Barat Provinsi Kalimantan Tengah

Abstract Kotawaringin Barat is a filariasis endemic area and has been undergoing mass drugs adminstration (MDA) for 5 years. The district passed third phase of Transmission Assesment Survey (TAS-3) in 2016. In the TAS-3, we found 4 children with filariasis antibodies. In this study, we performed microscopic examination of microfilaria to confirm the results of TAS-3, as well as the measurement of knowledge, attitudes, and behavior towards the treatment of filariasis. The study was conducted in Dawak Village and Sungai Bakau Village, with a total sample of 620 respondents. The results of microscopic examination are 5 respondents with Brugia malayi in their blood, consisting of 4 respondents in Dawak Village and 1 respondent in Sungai Bakau Village. The percentage of respondents who know the causes and symptoms of filariasis is very small. Although most respondents have a positive attitude towards treatment, the right treatment behavior is still very low. One respondent was found to be reinfected with B. malayi. In addition, it is suspected that there is transmission from animals to humans, but it still needs further investigation.

Evaluasi Penularan Filariasis Limfatik di Provinsi Riau dan Bangka Belitung: Parasit pada Manusia dan Reservoir

Mass treatment and evaluation surveys of filariasis transmission were strategies in the control of lymphatic filariasis. Mass Drug Administration (MDA) stop period surveillance is required for five years before obtaining a lymphatic filariasis elimination certificate. The aim of conducting the study was to evaluate the activities of lymphatic filariasis elimination in areas that have been doing MDA for five years. During July-November 2017, fingertip blood samples of people aged five years and examination of reservoir animals was done in Riau and Bangka Belitung Province. The results of the study found that in Kuatan Singingi and Pelalawan district Mf rate was &lt;1%, in West Bangka and Belitung districts Mf rate&gt; 1% with all specied identified as Brugia malayi. Survey of animal reservoir obtained positive of B. malayi on two cats (Felis attus), one dog (Canis familiaris), and one monkey (Macaca fascicularis). Riau Province was not a filariasis endemic area (Mf rate &lt;1%), while Bangka Belitung Province Mf rate was still &gt;1%. The risk of transmission in Kuantan Singingi District was already low, while in Pelalawan regency, West Bangka and Belitung were still high.

Factors Determining Drug Uptake During Mass Drug Administration in Banyuasin District, South Sumatera, Indonesia

The community participation in taking drugs to prevent filariasis can reduce the risk of contracting filariasis, especially those who live in filariasis-endemic areas. People who do not take filariasis medication at the time of filariasis through mass drug administration (MDA) will be more at risk for contracting filariasis. WHO filariasis program target on 2000 stated that the minimum MDA coverage that must be achieved to break the chain of transmission is 85%, while the Banyuasin district has not reached the set target. This study aims to identify the factors determining drug uptake during Mass Drug Administration in Banyuasin District 2018. This study used a cross-sectional study design, the sample of this study was 200 samples of heads of families selected in a cluster random sampling. The analysis method of this study uses univariate, bivariate using the chi-square test and multivariate using multiple logistic regression tests. The results of this study found that the proportion of respondents taking filariasis drug was 75.5%. The variables that significantly correlated with taking filariasis drug were attitudes (PR 1,89; 95% CI 1.08-3.18) and support from Elimination Executing Staff (PR 2,06; 95% CI 1,24-3,44). The behavior of taking medicine in the MDA FIlariasis activities in Banyuasin District was not good. Hence, health workers are expected to be more active in conducting counseling to improve community participation in the Filariasis MDA activities.