Field Of Therapeutics Research Articles

Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine

The human microbiome, a complex ecosystem of microorganisms residing in and on the body, plays a pivotal role in the regulation of a wide range of physiological processes, including digestion, immune responses, and metabolic functions. In recent years, the rapidly growing field of microbiome-driven therapeutics has garnered significant attention owing to its potential to revolutionize healthcare. This review explores the evolving landscape of microbiome-based therapies, with a particular focus on the gut microbiome and its implications for both gut health and precision medicine. We highlight recent advances in understanding how microbial communities influence disease pathogenesis and treatment outcomes, spanning conditions such as inflammatory bowel disease (IBD), metabolic disorders, neurological diseases, and even cancer. This article also discusses emerging therapeutic strategies, including probiotics, prebiotics, fecal microbiota transplantation (FMT), and microbial-based drugs, as well as the challenges associated with their clinical implementation. Additionally, we examined how the integration of microbiome profiling and metagenomic data is advancing the field of precision medicine, paving the way for personalized and effective treatments. This review serves as a comprehensive resource that synthesizes current knowledge, identifies key gaps in microbiome research, and offers insights into the future direction of microbiome-driven therapeutics, thus providing a valuable framework for clinicians, researchers, and policymakers seeking to harness the potential of microbiomes to advance personalized healthcare solutions.

An Overview on Development and Evaluation of Nail Serum for Nail Care

Nail serums have emerged as a significant innovation in personal care, addressing common issues like brittle, weak, and damaged nails. These formulations are designed to deliver targeted nourishment and therapeutic benefits through a combination of moisturizing agents, strengthening compounds, antioxidants, and growth enhancers. By penetrating the nail plate and reaching the matrix, nail serums provide hydration, repair, and fortification at the cellular level. This review delves into the active ingredients commonly used in nail serums, including biotin, keratin, hyaluronic acid, and essential oils, and discusses their mechanisms of action and clinical efficacy. Recent advancements, such as nanotechnology and sustainable ingredient sourcing, are also explored, showcasing the evolution of nail care products. Furthermore, challenges such as regulatory compliance and consumer education are highlighted, along with opportunities for future research and innovation. This comprehensive analysis aims to enhance understanding of nail serums' role in promoting nail health and their potential applications in both therapeutic and cosmetic fields.

Dosimetry Software for Theranostic Applications: Current Capabilities and Future Prospects.

Dosimetry is integral to informed implementation of radiopharmaceutical therapies, enabling personalized treatment planning and ensuring patient safety by calculating absorbed doses to organs and tumors. As the therapeutic radiopharmaceutical field continues to expand, dosimetry software has emerged as a crucial tool for optimization of treatment efficacy. This review discusses key features and capabilities that current dosimetry software solutions have or should have in the future. We highlight the need for standardization across platforms to support consistent and accurate dose calculations. Furthermore, we explore opportunities for advancing software, such as incorporating biologically effective dose modeling and improving uncertainty quantification. Looking ahead, we advocate for expanding infrastructure for open data sets and fostering ongoing collaboration between vendors and end users to guide the field toward greater integration and efficacy.

Marine-Derived Compound Targeting mTOR and FGFR-2: A Promising Strategy for Breast, Lung, and Colorectal Cancer Therapy.

The marine habitat is a plentiful source of diverse, active compounds that are extensively utilised for their medicinal properties. Pharmaceutical trends have currently changed towards utilising a diverse range of goods derived from the marine environment. This study aimed to examine the inhibitory effects of bioactive chemicals derived from marine algae and bacteria. The identification of these compounds was carried out through the process of Gas Chromatography-Mass Spectrometry (GC-MS) profiling. Subsequently, these compounds were subjected to docking simulations against a specific set of target proteins that are known to be frequently overexpressed in three distinct types of cancer. From the docking results, the ligand 1,4:3,6:5,7-Tribenzal-beta-mannoheptitol was found to be effective against the proteins mTOR (PDB ID: 4JSV) and FGFR2 (PDB ID:6V6Q). The findings of this study highlight the significant benefits offered by the tool under investigation, which effectively enhances the efficiency of the docking procedures. These compounds hold significant potential for further development and exploration in the field of cancer therapeutics.

Intracellular Delivery of Proteins by Protein-Recognizing Nanoparticles.

Intracellular delivery of proteins can directly impact dysregulated and dysfunctional proteins and is a key step in the fast growing field of protein therapeutics. The vast majority of protein-delivery systems enter cells through endocytic pathways, but endosomal escape is a difficult and inefficient process, demanding fundamentally different methods of delivery. We report ultrasmall cationic molecularly imprinted nanoparticles that bind protein targets with high specificity through their uniquely distributed surface lysine groups. The nanoparticle-protein complexes enter cells even when energy-dependent endocytic pathways are inhibited. The micromolar binding affinities of the nanoparticle for the proteins are strong enough for the cargos to be bound during loading and transportation but weak enough to be released into cytosol for them to interact with the desired cellular targets. The nanoparticles display low cytotoxicity to cells and can be functionalized with fluorescent labels through click chemistry for easy tracking. Both the molecular imprinting and delivery work well for proteins with a range of molecular weights and isoelectric points, affording a convenient method to manipulate cellular functions and intracellular reactions through delivered proteins.

Recognition of mixed-sequence double-stranded DNA regions using chimeric Invader/LNA probes.

Development of robust oligonucleotide-based probe technologies, capable of recognizing specific regions of double-stranded DNA (dsDNA) targets, continues to attract considerable attention due to the promise of tools for modulation of gene expression, diagnostic agents, and new modalities against genetic diseases. Our laboratory pursues the development of various strand-invading probes. These include Invader probes, i.e., double-stranded oligonucleotide probes with one or more +1 interstrand zipper arrangements of intercalator-functionalized nucleotides like 2'-O-(pyren-1-yl)methyl-RNA monomers, and chimeric Invader/γPNA probes, i.e., heteroduplex probes between individual Invader strands and complementary γPNA strands. Here we report on the biophysical properties and dsDNA-recognition characteristics of a new class of chimeric probes-chimeric Invader/LNA probes-which are comprised of densely modified Invader strands and fully modified complementary LNA strands. The chimeric Invader/LNA probes form labile and distorted heteroduplexes, due to an apparent incompatibility between intercalating pyrene moieties and LNA strands. In contrast, the individual Invader and LNA strands form very stable duplexes with complementary DNA, which provides the driving force for near-stoichiometric recognition of model double-stranded DNA targets with single base-pair accuracy. The distinctive properties of chimeric Invader/LNA probes unlock exciting possibilities in molecular biology, and diagnostic and therapeutic fields.

Efficient CRISPR Cas13 in The Treatment of The COVID-19

Currently, CRISPR Cas13 is one of the rapid advancement and growing potential in the fields of diagnostics and therapeutics. It has proven highly effective in detecting RNA viruses like SARS-CoV-2, making it an essential tool for identifying COVID-19 variants. However, since CRISPR Cas13 is a newly emerged technology in the CRISPR system, there are still some problems that need to be tackled. This article aims to discuss the application of CRISPR Cas13 in treating COVID 19. Two CRISPR Cas13 based diagnostic tools, PAC-MAN and CARMEN, hold potential for detecting variants, with research indicating their ability to degrade viral RNA and suppress viral gene expression. Despite this potential, challenges remain, particularly in achieving efficient and safe delivery systems for Cas13. While it is not yet fully implemented in clinical settings, the progress made so far highlights CRISPR Cas13’s significant role in addressing viral outbreaks, specifically COVID 19 and its potential for future applications in infectious diseases and other RNA-based conditions.

From diagnosis to rehabilitation of trigger finger: a narrative review.

Trigger finger (TF), also known as stenosing flexor tenosynovitis, is a common pathology of the fingers causing functional deficit of the hand. In recent years, new therapeutic approaches such as extracorporeal shock wave therapy (ESWT) and ultrasound-guided (USG) procedures have joined the most traditional conservative treatments as the adaptation of daily activities involving the affected hand and the orthosis. Likewise, the ultrasound (US) examination of the affected finger using modern high-frequency probes has progressively become part of the comprehensive assessment of patients with TF coupled with the medical history, the physical examination, and the functional scales. In this sense, considering the technological advances in both diagnostic and therapeutic fields, the non-surgical strategies have progressively grown defining a rehabilitation panel more complex than in the past. The present manuscript aims to provide an updated practical guide for clinicians and surgeons reviewing the state-of-art of both the assessment and the treatments of patients with TF to plan tailored rehabilitation management taking advantage of the matching of traditional and novel techniques.

Translational research priorities for bacteriophage therapeutics.

The growing threat of antimicrobial resistant (AMR) bacterial pathogens coupled with the relative dearth of promising novel antibiotics requires the discovery and development additional medical interventions. Over the past decade bacteriophages have emerged one of the most promising new tools to combat AMR pathogens. Anecdotal clinical experiences under so-called 'compassionate use' regulatory pathways as well as a limited number of clinical trials have provided ample evidence of safety and early evidence of efficacy. For phages to reach their full potential it is critical that rigorous clinical trials be conducted that define their optimal use and that enable regulatory authorities to support the commercialization required to afford global access. The clinical development of phage therapeutics requires the design and execution of clinical trials that take full advantage of lessons learned from a century of antibiotic development and that use clinical investigation as a platform in which aspects of phage biology that are critical to therapeutics are more clearly elucidated. Translational research that elucidates phage biology in the context of clinical trials will promote highly relevant hypothesis-driven work in basic science laboratories and will greatly accelerate the development of the field of phage therapeutics.

Cataractous Eye Protein Isolate Stabilized Gold Nanoparticles Prevent Their Ethanol-Induced Aggregation.

Due to their distinctive optical, electrical, and catalytic characteristics, gold nanoparticles (AuNPs) have found increasing use for a wide range of applications, including biomedicine and catalysis. Inherent agglomeration propensities impair their functional qualities, stability, and biocompatibility. This work investigates the potential applications of the cataractous eye protein isolate (CEPI), a waste product rich in proteins from cataract surgery, as a novel AuNP stabilizing agent. It was found that CEPI can successfully stabilize AuNPs under a variety of situations, preventing ethanol-induced aggregation and preserving their structural integrity. Using spectroscopic and analytical techniques, including UV-Vis spectroscopy, dynamic light scattering (DLS), circular dichroism (CD) spectroscopy, and fluorescence quenching studies, we confirmed the successful binding of CEPI to AuNPs and the enhanced stability of the conjugates. A shift in the localized surface plasmon resonance (LSPR) peak and modifications to the secondary structure of the CEPI were indicative of strong binding and protective effects between CEPI and AuNPs. These findings suggest that CEPI, an underutilized biomaterial, can serve as an effective and biocompatible stabilizer for AuNPs, with potential applications in biomedical and therapeutic fields.

Recent Advancements in CT Detectors: A Comprehensive Review

The Computed Tomography (CT) scanners are widely used in the diagnostic and therapeutic medical fields due to their quick scanning times, excellent spatial resolution and widespread availability. The X-ray detector is essential for creating images and has a significant impact on radiation dose and image quality. All current commercial scanners use solid-state detectors and are comparable to third-generation technology. Detector characteristics include efficiency, stability, response time and afterglow. CT scanners have been used since 1971, and in the intervening decades, the technology has advanced tremendously. Notable developments in detector technologies have improved image quality and decreased radiation doses. The EMI head scanner was first equipped with Sodium Iodide (NaI) detectors, which necessitated long scan periods and a water bath to control detector saturation. These designs were improved upon by later generations, which offered quicker scanning speeds and better image quality. While the fourth generation of scanners used a stationary ring of detectors to drastically reduce scan durations, the thirdgeneration scanners introduced fan beams and rotation-rotation action. The sixth generation, called dual-source CT, allowed for dual-energy imaging using two X-ray tubes. The fifth generation, called electron-beam CT, produced X-rays using an electron beam. The seventh generation replaced traditional X-ray film with Flat-panel Detectors (FPD), which improved imaging. CT detector advancements include gemstone, stellar, photon counting, and NanoPanel prism detectors. The gemstone scintillator material is produced by General Electric Healthcare (GEHC). The Photon-counting Detector (PCD) is a new CT detector technology that uses a direct conversion X-ray detector to record X-ray photon energies. The stellar detector is based on Siemens Healthineers, and the NanoPanel prism detector is based on Philips. The present article discusses the recent trends in CT detector technology.

Emerging therapeutic strategies to mitigate female and male reproductive aging.

People today are choosing to have children later in life, often in their thirties and forties, when their fertility is in decline. We sought to identify and compile effective methods for improving either male or female fertility in this context of advanced reproductive age. We found few clinical studies with strong evidence for therapeutics that mitigate reproductive aging or extend fertility; however, this Perspective summarizes the range of emerging experimental strategies under development. Preclinical studies, in mouse models of aging, have identified pharmaceutical candidates that improve egg and sperm quality. Further, a diverse array of medically assisted reproduction methodologies, including those that stimulate rare ovarian follicles and rejuvenate egg quality using mitochondria, may have future utility for older patients. Finally, we highlight the many knowledge gaps and possible future directions in the field of therapeutics to extend the age of healthy human reproduction.

Synergistic Bioactivity of Aegiceras corniculatum (L.) Blanco and Its Endophytic Fungus Aspergillus: Antioxidant, Antimicrobial, and Cytotoxic Effects.

The mangrove fungi provide a vast and unexplored source of diverse and unique chemicals and biological properties. The plant Aegiceras corniculatum (L.) Blanco and its endophytic fungus aspergillus species were collected from different sites of the Baleswar river region in Sundarban. Hence, we compared the antioxidant properties of the associated fungus ACSF-1 and the methanolic bark extract of Aegiceras corniculatum (MBAC) by measuring the total phenolic content (TPC), total flavonoid content (TFC), and DPPH free radical assay. Subsequently, antimicrobial activity was measured using the disc diffusion method, and cytotoxic activity was measured using the brine shrimp lethality bioassay. The results showed that MBAC has even more DPPH scavenging activity (IC50 = 44.036 μg/mL), TPC (310.275 mg GAE/g), and TFC (66.275 mg QE/g) in comparison with DPPH scavenging activity (IC50 = 92.542 μg/mL), TPC (234.832 mg GAE/g), and TFC (134.887 mg QE/g) in ACSF-1. The median lethal concentration value (LC50) of MBAC and ACSF-1 was found to be 43.93 μg/mL and 336.84 μg/mL, respectively. Moreover, MBAC showed a dose-dependent antimicrobial response to Escherichia coli and Staphylococcus aureus, whereas ACSF-1 was found to have activity against Bacillus subtilis and S. aureus. These results emphasize the unique pharmacological characteristics of both the plant and fungus, indicating their potential usefulness in various therapeutic fields.

Exploring the interaction of hesperetin-mediated green synthesised gold and silver nanoparticles with human serum albumin: A comparative analysis

This study focused on evaluating the potential of hesperetin-functionalized silver (H-AgNPs) and gold nanoparticles (H-AuNPs) for biomedical use, with a primary objective of understanding their relative binding affinity to human serum albumin (HSA). We evaluated the strength and possible binding mechanisms of the interaction between the nanoparticles and HSA based on analyses from fluorescence studies, UV–visible absorption, lifetime measurements and isothermal titration calorimetry (ITC). Circular dichroism analysis was employed to examine the conformational changes in HSA upon complexation with H-AgNPs and H-AuNPs. Furthermore, the thermodynamic parameters derived from ITC provided insights into the stabilising forces driving the endothermic binding processes. Consistently, the binding constants derived from spectroscopic and calorimetric investigations elucidated the superior binding efficiency of H-AuNPs compared to H-AgNPs with HSA. Antibacterial study revealed that H-AgNPs exhibited significant activity against S. aureus and E. coli, revealing promising antibacterial effects. Contrarily, H-AuNPs demonstrated no activity in the study. From the MTT assay results, we observed that H-AgNPs exhibited higher anticancer activity against human lung cancer cells compared to H-AuNPs, while H-AuNPs demonstrated lower cytotoxicity than H-AgNPs. Based on our research findings, both nanoparticles hold promise as potential candidates for diverse applications in the therapeutic field.

Psychological Women's Liberation: Feminist Therapy Between Psychology and the Women's Movement in the Federal Republic of Germany in the 1970s

From the late 1960s onwards, the early second women's movement encompassed all areas of West German society. This included debates about how women's healthcare could be improved in aself-determined, women-friendly way and in line with feminist ideals. These debates were also held with regard to the general boom in psychotherapy at the time. This article explores the question of how debates around feminist therapy emerged in the Federal Republic of Germany. It also looks at the tense relationship between psychology and psychotherapy. While feminist women's counselling and therapy centers became awidespread part of apsychosocial care network from the late 1970s onwards, scientific psychology in German speaking countries remained largely closed to feminist influences. The article traces how this imbalance between feminist therapeutic practice and psychological women's research came about. Therefore, the article sets out from 1974, when psychologists tried to introduce feminist impulses into academic psychology and feminist activists made psychotherapeutic approaches usable for the women's movement. Many female psychologists shifted their commitment from the academic to the therapeutic field. It is argued, that this was due to the less than conducive conditions that feminist-oriented psychologists found in German-speaking academic psychology.

Abstract PR007: To the tumor and beyond: Tales of a holistic miRNA delivery vehicle

Abstract Like the challenges and skepticism that faced the antibody therapeutics field over a decade ago, RNA therapeutics is facing the same. And, like the antibody therapeutics field, we are beginning to realize the clinical impact of RNA therapeutics amiss these challenges. This is most clearly highlighted with the recent approval of mRNA vaccines and RNAi drugs targeted to the liver. Unfortunately, RNA-based drugs targeted to tumors is lagging behind, even with countless years of work that has revealed the power of using RNAi for treating oncological diseases. Lack of success is attributed to inability to deliver RNAi safely and effectively. A successful delivery agent requires multiple features. First, the agent must deliver the RNA specifically to the intended cells. Second, the agent must have a large therapeutic window, meaning that toxicity, if observed, should occur at doses that are orders of magnitude higher than the therapeutic dose. Third, if delivery of the RNA is by way of a specific ligand and receptor pair, as is the case herein, the RNA must successfully escape the endosome. Simply swelling the endosome is not enough if noncovalent interactions between the ligand and the receptor cannot be disrupted. Fourth, the RNA should include appropriate stabilizing modifications to increase intracellular half-life that will reduce dosing and cost. Through hard work and dedication, we have come up with an inclusive, easily synthesized, intramolecular molecule that achieves all of these essential features. Here, the challenges we face, the hurdles we have overcome, and the barriers that still remain with achieving success in reveling the clinical potential of miRNAs as anti-cancer therapeutics will be presented. Citation Format: Andrea L Kasinski. To the tumor and beyond: Tales of a holistic miRNA delivery vehicle [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: RNAs as Drivers, Targets, and Therapeutics in Cancer; 2024 Nov 14-17; Bellevue, Washington. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(11_Suppl):Abstract nr PR007.

Preparation of Golf Ball-like Polymer Particles Bearing Site-Selective Functional Groups.

Golf ball-like particles have emerged as interesting materials in the fields of therapeutics, diagnostics, chemical sensing, etc. because of their unique shapes (with concave and convex moieties) and physical properties. Despite their uniqueness, their surfaces are generally covered with single components lacking functional groups, and a well-established functionalization method for a specific area of these particles, such as their concave or convex surface, is lacking. Thus, we proposed a seeded-dispersion polymerization (SDP)-based method for preparing anionic- and cationic-group-bearing golf ball-like polymer particles mainly on their convex surface. Briefly, we prepared golf ball-like particles with site-selective functional groups by subjecting n-butyl methacrylate (nBMA) to SDP in the presence of polystyrene-seed particles and dodecane using 2,2'-azobis(isobutyronitrile) as an initiator; this yielded a poly(nBMA), PnBMA, concave phase. The shape of the golf ball-like particles was also controlled by adjusting the nBMA amount and solvent composition. Further, the results revealed that the functional groups were introduced onto the convex surface of the golf ball-like particles, and the position of the ionic groups on the particles was confirmed based on metal-nanoparticle adsorption. Thus, we demonstrated the feasibility of preparing convex surfaces of golf ball-like particles to impart such surfaces with anionic or cationic functional groups, thereby expanding the application scope of these heteromorphic particles.

INNV-34. APPLICATION OF 200 KHZ TUMOR TREATING FIELDS (TTFIELDS) IN PATIENTS WITH INFRATENTORIAL HIGH-GRADE GLIOMA: CASE SERIES

Abstract BACKGROUND 200 kHz Tumor Treating Fields (TTFields) therapy is FDA-approved for supratentorial newly-diagnosed and recurrent glioblastoma. However, reports of its application in patients with infratentorial high-grade glioma (HGG) are rare. Based on computational modeling, the therapeutic field strength (~1 V/cm peak-to-peak) is thought to be achievable for infratentorial HGG. METHODS Two patients with infratentorial HGG received off-label 200 kHz TTFields therapy with the Optune® device (Novocure, Ltd.). To reduce impaired range of motion of the neck, the electrode transducer arrays were “skeletonized” by cutting a portion of the adhesive material surrounding them. Application of the electrode arrays was performed with the neck in flexion, to further promote neck range of motion. Cloth tape was used for reinforcement as necessary. Electrode arrays were changed every 2-3 days. We report the results of patient survival and adverse events. RESULTS Patient 1: 22-year-old man with high-grade diffuse pontine glioma with recurrences and prior treatments (including radiation, temozolomide, lomustine, and dopamine receptor D2 [DRD2] antagonist), tolerated TTFields combined with systemic treatment (initially with a bi-functional DNA alkylating agent; subsequently with temozolomide and bevacizumab) for 5 months with stable disease for 4 months. He experienced grade 1 rash of the neck. Patient 2: 58-year-old woman with diffuse glioma of the brainstem (H3K27M-mutated) with multiple recurrences and prior treatments (including concurrent radiation and temozolomide, and DRD2 antagonist), tolerated TTFields combined with systemic treatment (lomustine and bevacizumab). The TTFields infratentorial layout was iteratively modified with respect to placement of the electrode transducer arrays, for improved tolerability. With the TTFields+systemic combination therapy, the patient was stable for 8 months with no local TTFields-related side effects. CONCLUSIONS We provide initial post-marketing evidence that off-label use of 200 kHz TTFields in infratentorial HGG is safe and feasible. Prospective studies are necessary to validate the efficacy of this approach.

Living Cell-Mediated Catalyst-Free Spontaneous Polymerization of Zwitterionic Methacrylates for Preparation of Probiotic-Loaded Hydrogels.

Living cell-mediated polymerization offers promising applications in biomaterials, yet its further biological utilization is hindered by the need for metal ions or radical initiators with available methods. In this study, we introduce a living cell-mediated polymerization that leverages the intrinsic metabolic activities of living cells to initiate and sustain free radical polymerization of zwitterionic methacrylates. The polymerization proceeded in the absence of transition metal catalysts, radical initiators, or light sources. The conversion of zwitterionic methacrylate strongly correlated with cellular activities and achieved a maximum conversion of 98 % within 48 hours. Living cells efflux redox power across membranes through metabolism and that terminal electron fluxes are captured by zwitterionic methacrylates pre-assembled on the living cell surface to initiate radical polymerization reactions. The polymerization caused significant changes to the cell membrane surface and synthesized hydrogels with tailored mechanical properties. The polymer hydrogel obtained via probiotic E. coli Nissle 1917 was able to release the in situ encapsulated molecules, which demonstrated living cell-mediated polymer hydrogel as a vehicle for the delivery of both cellular and molecular therapeutic agents. This research offered a green and efficient method for synthesizing bioactive materials and advancing the field of cellular therapeutics and drug delivery.

Living Cell‐Mediated Catalyst‐Free Spontaneous Polymerization of Zwitterionic Methacrylates for Preparation of Probiotic‐Loaded Hydrogels

AbstractLiving cell‐mediated polymerization offers promising applications in biomaterials, yet its further biological utilization is hindered by the need for metal ions or radical initiators with available methods. In this study, we introduce a living cell‐mediated polymerization that leverages the intrinsic metabolic activities of living cells to initiate and sustain free radical polymerization of zwitterionic methacrylates. The polymerization proceeded in the absence of transition metal catalysts, radical initiators, or light sources. The conversion of zwitterionic methacrylate strongly correlated with cellular activities and achieved a maximum conversion of 98 % within 48 hours. Living cells efflux redox power across membranes through metabolism and that terminal electron fluxes are captured by zwitterionic methacrylates pre‐assembled on the living cell surface to initiate radical polymerization reactions. The polymerization caused significant changes to the cell membrane surface and synthesized hydrogels with tailored mechanical properties. The polymer hydrogel obtained via probiotic E. coli Nissle 1917 was able to release the in situ encapsulated molecules, which demonstrated living cell‐mediated polymer hydrogel as a vehicle for the delivery of both cellular and molecular therapeutic agents. This research offered a green and efficient method for synthesizing bioactive materials and advancing the field of cellular therapeutics and drug delivery.