Aim/Purpose: The purpose of this paper is to examine the key research foci, methodologies, and theoretical perspectives adopted by researchers when studying E-government accessibility for persons with disabilities (PWDs), particularly in developing countries. The study aims to develop a conceptual framework for designing accessible E-government for PWDs in developing countries. Background: Studies on E-government accessibility for persons with disabilities in developing countries have been minimal. The few studies conducted until now have failed to integrate PWDs, a population already marginalized, into the digital society. Accessibility has been identified by researchers as a major hindrance to PWDs participating in E-government. It is imperative therefore to examine the manner in which researchers investigate and acquire knowledge about this phenomenon. Methodology : The study synthesizes literature from top IS journals following a systematic literature review approach. The data synthesis focuses on identifying key concepts relating to E-government accessibility for PWDs. Contribution: The study contributes to the field of E-government, with a focus on how E-government services can be made accessible to PWDs. The study calls on researchers to reflect on their epistemological and ontological paradigms when examining accessibility of E-government services in developing countries. Findings: The findings show that most researchers focus on the evaluation of E-government websites and predominantly adopt quantitative methods. The study also reveals that the use of technological determinism as a theoretical lens is high among researchers. Recommendations for Practitioners : The study recommends that E-government web developers and policy makers involve PWDs from design to evaluation in the development of E-government applications. Recommendation for Researchers: The study advocates the need to conduct studies on E-government accessibility by employing more qualitative and mixed approaches to gain in-depth and better understanding of the phenomenon. Impact on Society : This study creates greater awareness and points out inadequacies that society needs to address to make E-government more inclusive of and participatory for PWDs. Future Research: Further empirical work is required in order to refine the relevance and applicability of various constructs in EADM so as to arrive at a framework for addressing E-government accessibility for PWDs in developing countries.