This literature review sought to identify and evaluate the current applications of artificial intelligence (AI)/machine learning (ML) in spine surgery that can effectively guide clinical decision-making and surgical planning. By using specific keywords to maximize search sensitivity, a thorough literature research was conducted in several online databases: Scopus, PubMed, and Google Scholar, and the findings were filtered according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 46 studies met the requirements and were included in this review. According to this study, AI/ML models were sufficiently accurate with a mean overall value of 74.9%, and performed best at preoperative patient selection, cost prediction, and length of stay. Performance was also good at predicting functional outcomes and postoperative mortality. Regression analysis was the most frequently utilized application whereas deep learning/artificial neural networks had the highest sensitivity score (81.5%). Despite the relatively brief history of engagement with AI/ML, as evidenced by the fact that 77.5% of studies were published after 2018, the outcomes have been promising. In light of the Big Data era, the increasing prevalence of National Registries, and the wide-ranging applications of AI, such as exemplified by ChatGPT (OpenAI, San Francisco, California), it is highly likely that the field of spine surgery will gradually adopt and integrate AI/ML into its clinical practices. Consequently, it is of great significance for spine surgeons to acquaint themselves with the fundamental principles of AI/ML, as these technologies hold the potential for substantial improvements in overall patient care.