A field experiment was conducted during the winter season 2022-2021 in the field experiments field of the College of Agriculture - Al-Qasim Green University in the south of Babylon province, located at latitude 32.40 north and longitude 44.39 east. In order to study the effect of planting date and stages of spraying with the physiological stimulant Appetizer on the growth and yield of wheat (Triticum aestivum L.)), the experiment was conducted by arranging the split plots according to the Randomized Complete Block Design (RCBD) with three replicates. The planting dates included the main plot T1, a suitable first date on 15/11 and T2 a second late date on 15/12, while the subplot included spraying with the physiological stimulant (Appetizer) according to the stages of wheat growth within the Zadoks classification, which was given the symbols (A0 without spraying and A1 stage, The results showed that the date of 11/15 was significantly excelled in the studied traits for plant height 83.24 cm, spike length of 11.82 cm, area of flag leaf 38.09 cm 2, chlorophyll content of 71.98, and number of grains in spike 43.6. grain. Spike -1 The number of spikes is 364. Spikes. m-2 The grain yield is 3.84 tons. ha-1 and the harvest index is 34.14%, As for the phases of spraying with the physiological stimulant Appetizer, they significantly excelled at the elongation and booting growth stage in the studied traits, including plant height 81.70 cm, spike length 11.80 cm, chlorophyll content 74.65, number of grains 48.9 grains, spike 1- and grain yield 4.17 tons. ha-1 and a harvest index of 37.75%. As for the area of the flag leaf and the number of spikes, they significantly excelled at the stage of tillering and elongation, as their mean values reached 40.08 cm2 and 368 spikes.m2 respectively. As for the interaction between the planting dates and the phases of spraying with the physiological stimulant (Appetizer), it was significant in all the studied traits. The interaction between the date of 15/11 and the phases of spraying with the physiological stimulant at the elongation and booting stage gave the highest average plant height of 84.14 cm and spike length of 12.57 cm. the content of chlorophyll and the number of grains in the spike is 52.7 grains. spike -1 and the grain yield is 4.66 tons. ha-1 and the harvest index is 40.64%. As for the area of the flag leaf and the number of spikes, the interaction was significant between the date of 11/15 and the spraying phase when treated at tillering and elongation averaged 45.29 cm2 and 381 spikes.m2 sequentially.