The renormalization of the vacuum energy in quantum field theory (QFT) is usually plagued with theoretical conundrums related not only with the renormalization procedure itself, but also with the fact that the final result leads usually to very large (finite) contributions incompatible with the measured value of Lambda in cosmology. As a consequence, one is bound to extreme fine-tuning of the parameters and so to sheer unnaturalness of the result and of the entire approach. We may however get over this adversity using a different perspective. Herein, we compute the zero-point energy (ZPE) for a nonminimally coupled (massive) scalar field in FLRW spacetime using the off-shell adiabatic renormalization technique employed in previous work. The on-shell renormalized result first appears at sixth adiabatic order, so the calculation is rather cumbersome. The general off-shell result yields a smooth function rho _{mathrm{vac}}(H) made out of powers of the Hubble rate and/or of its time derivatives involving different (even) adiabatic orders sim H^N (N=0, 2,4,6,ldots ), i.e. it leads, remarkably enough, to the running vacuum model (RVM) structure. We have verified the same result from the effective action formalism and used it to find the beta -function of the running quantum vacuum. No undesired contributions sim m^4 from particle masses appear and hence no fine-tuning of the parameters is needed in rho _{mathrm{vac}}(H). Furthermore, we find that the higher power sim H^6 could naturally drive RVM-inflation in the early universe. Our calculation also elucidates in detail the equation of state of the quantum vacuum: it proves to be not exactly -1 and is moderately dynamical. The form of rho _{mathrm{vac}}(H) at low energies is also characteristic of the RVM and consists of an additive term (the so-called ‘cosmological constant’) together with a small dynamical component sim nu H^2 (|nu |ll 1). Finally, we predict a slow (sim ln H) running of Newton’s gravitational coupling G(H). The physical outcome of our semiclassical QFT calculation is revealing: today’s cosmic vacuum and the gravitational strength should be both mildly dynamical.