Air pollution is among the nastiest form of pollutions causing vexation over the globe. The recent situation of eco-toxicity showed that whole planet is facing this misery explicitly or implicitly. The essence of this enigma is rapid urbanization and industrialization. Global developmental activities, deforestation, uncontrolled industrial emission and increase in vehicular load made this environment unfit for healthy life. This research work explored the effect of air pollution on Physiochemical attributes of Ficus religiosa L. planted along the polluted roadsides of Lahore city. Leaf area, ascorbic acid contents (AAC), total chlorophyll content (TCh), pH of leaf extract, relative water contents (RWC), and dust accumulation on leaves surface were measured using standard methods. Air Pollution Tolerance Index was computed, and the results were compared with the control plants from Changa Manga forest, 70 Km away from Lahore city in cleaner locality. Several Physiochemical alterations in F. religiosa growing in polluted arias were observed, including average leaf area (1367�14.25mm2), AAC (0.68� 0.021 mg/g), TCh (8.50� 0.017) pH of leaf extract (7.17�0.018), RWC (92.5�0.076 %), and dust accumulation on leaves surface (0.0716�0.00063 mg/cm2) compare to control. The recorded average APTI value (10.32�0.023) was higher in the plants grown along the polluted roads compared to controls (9.39�0.012). It is concluded from the results that air pollution tolerance level of F. religiosa was higher along the polluted roads of Lahore. It depicts that they are considerably affected the prevailing air pollution.