Fibrous Type Research Articles

New Smopex® Ion Exchange Materials for the Removal of Selenium from Industrial Effluent Streams

This article discusses new Smopex® ion exchange materials which have been developed by Johnson Matthey Water Technologies, and highlights their performance relative to other commercially available materials for the removal of selenocyanate, selenate and selenite ions from aqueous solutions. The ion exchange mechanisms by which these materials sorb these ions are also explained and modelled in order to highlight the additional benefits that these materials offer that non ion-exchange materials do not, such as the ability to achieve the full material exchange capacities at feed concentrations lower than 1 mg l–1 selenium. The unique characteristics of these fibrous type materials are also discussed, including fast sorption kinetics, facile regeneration and enhanced selectivity for selenium ions against competing sulfate ions. Finally, the performance of these materials in a continuous stirred tank reactor setup is demonstrated, showing that performance levels as high as in fixed bed processes can be achieved, due to the high selectivity and mass transfer kinetics of Smopex® materials.

Algorithm of morphological assessment for predicting clinical course of juvenile nasopharyngeal angiofibroma

Aim. To determine the association between morphological characteristics of tumor growth and clinical manifestations of progression.
 Methods. The study included 118 patients with juvenile nasopharyngeal angiofibroma who were examined and treated at the department of head and neck cancer of Cancer Research Center of Uzbekistan from 2003 to 2013. The main group included 69 patients with primary nasopharyngeal angiofibroma, control group - 49 patients with relapsing tumors who underwent surgery. Standard histological examination was performed in all patients. The algorithm for determination of morphological changes degree was developed based on approach proposed by K.M. Mardaleyshvili (1985), which was modified by authors.
 Results. Seven most important morphological features of juvenile nasopharyngeal angiofibroma were outlined. On this basis, we proposed to determine the degree of morphological changes for the prediction and treatment monitoring, which is a graded scale for the signs in each of the seven groups. In the main group of patients with cell type of juvenile nasopharyngeal angiofibroma growth, the scores ranged from 10 to 13, marking the 1st degree of morphological changes. Patients with vascular fibrous type of tumor growth had 18-19 points, which corresponds to the 2nd degree of morphological changes in the tumor. Tumor samples of patients with vascular fibrous type of juvenile nasopharyngeal angiofibroma had the most evident morphological changes in the tumor tissue, which corresponded to 3rd degrees with the scores reaching 28.
 Conclusion. The proposed algorithm for determining the grade of morphological characteristics may be used for determining the treatment tactics and monitoring the tumor growth in patients with juvenile nasopharyngeal angiofibroma, as well as the prognostic factor.

Prognostic role of isolated left ventricular diverticuli detected by cardiovascular magnetic resonance

Isolated left ventricular diverticulum, a rare cardiac malformation, can be asymptomatic or associated with systemic embolization, ventricular arrhythmias, or sudden death. MRI allows for the detection of diverticuli and the distinction between fibrous and muscular types using the delayed enhancement technique. To evaluate the prevalence of left ventricular diverticuli in nonselected consecutive patients who had undergone MRI. In a total of 3273 consecutive patients who had undergone cardiac magnetic resonance from January 2001 to December 2005, isolated ventricular diverticuli were found in 25 patients (0.76%), with no apparent cardiac disease. A delayed enhancement technique was used to distinguish fibrous and muscular types. The prevalence of complications was evaluated with a follow-up of 52 ± 8 months. The site of the left ventricular diverticuli was the septum in 10 (37%) cases, inferior wall in 6 (22%) cases, lateral wall in 4 (15%) cases, and apical in 7 (26%) cases. In two cases, multiple diverticuli were found. In delayed enhancement images, a partial or total fibrous diverticulum was found in 6 (24%) patients. At follow-up, clinical complications were recorded in 6 (24%) patients; 2 (8%) patients had arrhythmic complications and 4 (12%) patients had embolic complications of presumed cardiac origin. In addition, two patients (8%) had nonsustained ventricular tachycardia diagnosed using 24-h ECG Holter monitoring. Fibrous type diverticuli were associated with a higher incidence of arrhythmic complications than the muscular type. The prevalence of isolated ventricular diverticuli detected by MRI is higher than that previously reported with other imaging techniques. Fibrous diverticuli are associated with a higher incidence of arrhythmic complications.

Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer.

Cancer-associated fibroblasts (CAFs) play key roles in tumor microenvironment; they are thought to originate from adipocytes. This study aimed to evaluate CAF-related protein expression and its implications in breast cancer. Of the 939 enrolled breast cancer patients, 642 had fibrous and 297 had adipose stroma. The status of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER-2), Ki-67, podoplanin, prolyl 4-hydroxylase, fibroblast activation protein α (FAPα), S100A4, platelet-derived growth factor receptor α (PDGFRα), PDGFRβ, and chondroitin sulfate proteoglycan (NG2) was evaluated via tissue microarrays. Tumors were divided into luminal A, luminal B, HER-2, or triple-negative breast cancer subtypes according to their molecular status. Luminal A subtype was more prevalent in breast cancer of adipose stroma type, whereas other molecular subtypes were more common in fibrous stroma type (p < 0.001). Tumor cell expression of podoplanin and FAPα was higher in adipose stroma type, while higher expression of prolyl 4-hydroxylase and PDGFRα was observed in fibrous stroma type. Furthermore, adipose stroma type exhibited higher stromal expression of podoplanin, FAPα, PDGFRβ, and NG2, whereas fibrous stroma type had higher prolyl 4-hydroxylase and S100A4 expression. In adipose stroma type, tumor positivity (p = 0.034) and stromal positivity (p = 0.005) of prolyl 4-hydroxylase were associated with shorter disease-free survival, and stromal prolyl 4-hydroxylase positivity was with shorter overall survival (p < 0.001). In conclusion, expression of CAF-related proteins was observed in breast cancer, with different profiles between adipose and fibrous stroma types. Prolyl 4-hydrolase status might be of prognostic value in adipose stroma type.

Effects of urokinase type plasminogen activator and plasminogen activator inhibitor-1 expressions on the formation of aneurysm of perimembranous ventricular septal defect

The exact mechanisms of defect closure in patients with perimembranous ventricular septal defect (PMVSD) remain unknown. We hypothesized that the expression of urokinase type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) may mediate extracellular matrix (ECM) remodeling in aneurysms. Seven normal heart tricuspid septal leaflet and 33 aneurysms were collected in Shanghai Renji Hospital and Shanghai Children's Medical Center from January 2008 to June 2010. Immunohistochemical expression of uPA and PAI-1 in 4 normal heart valvular tissues and 15 aneurysms was detected with immunohistochemical methods. The expression of uPA and PAI-1 mRNA in 3 normal heart valvular tissues and 7 aneurysms was studied by real time fluorescent PCR; the protein expression of uPA and PAI-1 in 4 normal heart valvular tissues and 11 aneurysms was tested with Western blotting. The surface of the aneurysms were completely covered by endothelial cells. Two types of granulation tissue, myxoid and fibrous, were associated with the aneurismal formation. uPA were recognized predominantly in valvar interstitial cells (VICs) which located mainly in regions adjacent to the endothelium and smooth muscle cells of blood vessels. PAI-1 was found in both VICs which located mainly in granulation tissue and endothelial cells. Nine aneurysms expressed a higher uPA activity than 4 normal valvular tissues ((74.6±11.8)% vs. (49.5±7.4)%; t = 3.87, P = 0.003) and six aneurysms expressed a low uPA activity ((10.3±3.1)% vs. (49.5±7.4)%; t=11.78, P=0.000) and a high PAI-1 activity ((55.2±1.7)% vs. (50.8±3.8)%; t=2.55, P=0.034) using immunohistochemical methods. uPA / PAI-1 ratio of protein expression tested by Western blot was 0.88±0.22 in four normal heart vavular tissues; five aneurysms expressed high uPA activity and low PAI-1 activity and uPA/PAI-1 ratio was 4.26±2.04; while the other 6 cases expressed low uPA activity and high PAI-1 activity and uPA/PAI-1 ratio was 0.30±0.07; the difference among the three groups was statistically significant (P<0.05). The rate of uPA/PAI-1 in relative copy of mRNA expression among normal heart valvular tissue, high uPA expressed aneurysms and low uPA expressed aneurysms are also significantly different (2.14±0.17 vs. 0.45±0.04; 2.14±0.17 vs. 4.38±1.41, P<0.05) respectively. The expression of uPA and PAI-1 in VICs suggests that interactions among these molecules contribute to the aneurysm formation and development. This provides a potential mechanism for defect closure in patients with PMVSD.

БИОНИЧЕСКИЕ ПРИНЦИПЫ ОПТИМИЗАЦИИ ТЕПЛО- И ХЛАДОПРОВОДОВ

Bionic approach to create technological devices based on the fact that a number of ideas and the basic elements of the device borrowed from living nature. In this case, it is postulated that over millions of years of evolution in living nature have already been found optimal solutions, which require only a correct interpretation. As a prototype of heat or cold conduits in living nature, taking into account the analogy between heat and mass transfer, select the root system of plants. In morphology root system of plants is divided into two types: fibrous root system type and taproot system. In accordance with these two types of heat reviewed: branched and unbranched. An algorithm for optimizing the shape and size of heating conduits. Received an analytical expression allowing to evaluate the warm-up time unbranched heat conductor and the maximum temperature that can be achieved in electric heating heat conductor. On the example of the longitudinal tube riffles forming atmospheric evaporators high pressure branched were optimized of heating conduits. The choice of the optimal form of ribs for chess and in-line tube bank. For staggered multiple rows of tubes is the best ribs in the form of snowflakes. For in-line tube bank proved optimal ribs with four diagonal ribs.

Micro‐Raman mapping of the polymorphs of serpentine

Serpentinites are rocks, often used in buildings, formed in large extent by minerals of the serpentine group: chrysotile, antigorite, lizardite, and polygonal serpentine. The fibrous type (e.g. chrysotile) of serpentine group minerals, along with several amphibole varieties (e.g. actinolite and tremolite), are the major components of asbestos family. The exposure to fine fibrous asbestos powder is linked to diseases such as pleural mesothelioma and asbestosis. The identification of the main varieties of the serpentine group, laminated or fibrous, becomes an issue of great interest for public health. This work introduces an analytical strategy able to distinguish the different serpentine polymorphs directly on the sample, allowing the analysis within their textural environment, evidencing at the micrometer scale the mineral reactions of the phases. Samples coming from the Koniambo massif (Grande Terre Island, New Caledonia) were studied by means of optical microscopy, scanning electron microscopy–energy dispersive X‐ray spectroscopy, and Raman spectroscopy. Raman peaks observed in the high wavenumber spectral range of 3550–3850 cm−1, associated with OH stretching vibrations, allow the discrimination of the all four serpentine varieties. The relationship between the different varieties of serpentine, at a micrometric scale, in complex samples, has been investigated by two‐dimensional Raman mapping. Copyright © 2015 John Wiley &amp; Sons, Ltd.

Defective Fas Expression on Bone Marrow Derived Cells Alters Atherosclerotic Plaque Morphology in Hyperlipidemic Mice.

Fas (CD95) is a member of the TNF-receptor family expressed on a wide range of cells. Interaction of Fas with its receptor, Fas ligand (Fas-L), stimulates an intracellular cascade of events that leads to apoptosis. Because apoptosis of inflammatory cells plays a key role in atherosclerosis we sought to determine the role of Fas in the development of atherosclerosis by repopulating the bone marrow cells of atherosclerosis-prone low density lipoprotein receptor null (LDL-R-/-) mice with either cells from lpr mice (lpr-BMT) that have defective Fas expression or from control mice (WT-BMT). The lpr-BMT mice exhibited no peripheral blood Fas expression 4 weeks after BMT. After consuming an atherogenic diet for 16 weeks, lpr-BMT mice developed atherosclerotic lesions characterized by smaller fibrous area with thinner fibrous cap and less TUNEL-positive staining compared to WT-BMT mice, although overall lesion size in lpr-BMT mice was similar to that of WT-BMT mice. Examination of a series of human atherosclerotic lesions revealed that many Fas-positive cells were colocalized with CD68-positive macrophages. Although apoptotic cells were rarely observed in the foam cell-rich fatty streak lesions, apoptotic CD68-positive macrophages in advanced lesions were detected in areas rich with inflammatory cells near the necrotic core. These observations suggest that Fas expression by the macrophages in atherosclerotic lesions can influence the plaque morphology towards a more fibrous type.

Collagen–gelatin mixtures as wound model, and substrates for VEGF-mimetic peptide binding and endothelial cell activation

In humans, high level of collagen remodeling is seen during normal physiological events such as bone renewal, as well as in pathological conditions, such as arthritis, tumor growth and other chronic wounds. Our lab recently discovered that collagen mimetic peptide (CMP) is able to hybridize with denatured collagens at these collagen remodeling sites with high affinity. Here, we show that the CMP’s high binding affinity to denatured collagens can be utilized to deliver angiogenic signals to scaffolds composed of heat-denatured collagens (gelatins). We first demonstrate hybridization between denatured collagens and QKCMP, a CMP with pro-angiogenic QK domain. We show that high levels of QKCMP can be immobilized to a new artificial matrix containing both fibrous type I collagen and heat denatured collagen through triple helix hybridization, and that the QKCMP is able to stimulate early angiogenic response of endothelial cells (ECs). We also show that the QKCMP can bind to excised tissues from burn injuries in cutaneous mouse model, suggesting its potential for promoting neovascularization of burn wounds.

Peripheral nerve conduits: technology update.

Peripheral nerve injury is a worldwide clinical problem which could lead to loss of neuronal communication along sensory and motor nerves between the central nervous system (CNS) and the peripheral organs and impairs the quality of life of a patient. The primary requirement for the treatment of complete lesions is a tension-free, end-to-end repair. When end-to-end repair is not possible, peripheral nerve grafts or nerve conduits are used. The limited availability of autografts, and drawbacks of the allografts and xenografts like immunological reactions, forced the researchers to investigate and develop alternative approaches, mainly nerve conduits. In this review, recent information on the various types of conduit materials (made of biological and synthetic polymers) and designs (tubular, fibrous, and matrix type) are being presented.

An experimental study of silicate–polymer gel systems to seal shallow water flow and lost circulation zones in top hole drilling

Abstract Shallow water and lost circulation are frequently encountered problems during drilling top holes of oil and gas wells. Plenty of methods have been applied to overcome these problems. Among these methods, silicate based gels are one of the oldest. For this study, Sodium-Silicate based gel system is investigated experimentally and several aspects of the system are improved for efficient field applications. This improved gel system is deliberately delayed, multi-component system to be mixed as a uniform liquid at the surface facilities but desired to form gel structure where it is placed in the well. Gel slurries are composed of distilled water, Sodium-Silicate solution, polymer solution, lost circulation materials, weighting agent and organic initiator (initiating the gelation). In this study, effect of these components on gel time, gel quality and gel strength at room temperature is investigated as a function of their concentration. In order to compare gelation time of different compositions, a new, easy and consistent gel time determination method is developed. Being based on vortex closure time, the method can be followed easily even by basic rig laboratories. Another new method is introduced to monitor long term gelation process by measuring turbidity (NTU) of the mixtures and plotting NTU versus time curves. In addition, unique observation codes are defined to compare the gel qualities of different compositions. For gel time and quality experiments, Sodium-Silicate concentrations from 3.5% to 15% by weight in the mixture were investigated and the concentrations range of 7.5–10% were found as applicable. It is determined that, gel time is getting higher as silicate–initiator ratio (SIR) increases for these optimum concentrations. The system is improved by addition of two different polymer solutions. These polymers not only improve the elasticity of the final gels but also provide sufficient viscosity to keep weighting agent and/or lost circulation materials (LCM) in suspension. In addition, viscosity development curves obtained from rotational viscometer at various constant shear rates indicated that, gelation is accelerated by applied shear. Furthermore, HTHP filter press cell was modified by manufacturing new bottom cap with 1 mm diameter hole in center to determine the extrusion pressures of the gels and it was found that, extrusion pressure can be increased by the addition of fibrous type lost circulation materials.

The spectrum of histomorphological findings related to joint endoprosthetics

Approximately 230,000 total hip and 170,000 knee joint endoprostheses are implanted in Germany annually of which approximately 10% (i.e. 40,000 interventions per year) are cases of revision surgery. These interventions involve removal of a previously implanted prosthesis which has resulted in complaints and replacement with a new prosthesis. There are manifold reasons for revision surgery, the most common indication being so-called endoprosthesis loosening, which is subdivided into septic and aseptic loosening. Histomorphological studies revealed that periprosthetic tissue from endoprosthesis loosening can be classified into four types (I) wear-particle induced type, (II) infectious type, (III) combined type and (IV) fibrous type. Types I and IV represent aseptic loosening and types II and III septic loosening. Recently, the topic of implant allergy has emerged. The detection of cellular, mostly perivascular lymphocytic infiltrates is discussed as being a sign of an allergic tissue reaction. It has most frequently been observed in type I periprosthetic membranes with a dense load of metal wear, which occurs with metal-on-metal bearings. Apart from endoprosthesis loosening, arthrofibrosis is another complication of joint endoprosthetics and can cause pain and impaired function. Histopathologically, arthrofibrosis can be evaluated by a three-tiered grading system. Furthermore, bone pathologies, such as ossification, osteopenia or osteomyelitis can occur as complications of joint endoprosthetics. This review gives an overview of the whole spectrum of pathological findings in joint endoprosthetics and offers a comprehensive and standardized classification system for routine histopathological diagnostics.

OBTENCIÓN Y CARACTERIZACIÓN DE HARINAS ELABORADAS A PARTIR DEL FRUTO MADURO DE Geoffroea decorticans “CHAÑAR” DE LA ZONA CENTRO–OESTE DE LA PROVINCIA DE FORMOSA, ARGENTINA

The aim of this study was to establish the pomological dimensions of the ripe fruits of G. decorticans, as well as to give the chemical characterization of the flours obtained from them in order to establish their potential uses. It has been shown that fruits are a resource of a high potential to manufacture flour that could be used for both human consumption and animal feeding. Percentual composition of the constituent parts of the fruit, as well as physical and chemical characterizations were determined. The fraction coming from exocarp and mesocarp (fraction A) represented 61 % of the fruit, yielding 94.7 % of flour, while the endocarp (fraction B) corresponding to 39 % of the whole fruit, yielded only 33.6 % of flour. Fraction A showed 84 % of carbohydrates and 8.9% of proteins. Although the seed makes up only 5 % of the fruit, it contains 50 % of oil. Flour from fraction B showed 80 % carbohydrates, mainly of the fibrous type. Physical parameters of fruits such as humidity, size, bulk density and weight were also evaluated.

Thermomechanical properties of poly(lactic acid) films reinforced with hydroxyapatite and regenerated cellulose microfibers

ABSTRACTNovel composite films constituted of poly(lactic acid) (PLA), hydroxyapatite (HAp), and two types of regenerated cellulose fillers—particulate and fibrous type—were produced by melt extrusion in a twin‐screw micro‐compounder. The effect of the film composition on the tensile and dynamic mechanical behavior and the HAp dispersion in the PLA matrix were investigated thoroughly. Appearance of crazed regions and prevention of HAp aggregation in the PLA matrix were elucidated in the composites with up to 15 wt % particulate cellulose content, which was the main reason for only slight reduction in the tensile properties, and consequently trivial degradation of their pre‐failure energy absorption as compared to neat PLA films. Superior dynamical energy storage capacities were obtained for the particulate cellulose modified composites, while their fibrous counterparts had not as good properties. Additionally, the anisotropic mechanical behavior obtained for the extruded composites should be favorable for use as biomaterials aimed at bone tissue engineering applications. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40911.

Experimental Research on Repair of the Degenerated Intervertebral Disc by Bone Marrow Stromal Stem Cell

Introduction Objective To observe the effects of halting, reversing degeneration of the intervertebral disc repair or repairing the degenerated intervertebral disc after bone marrow, stromal stem cells were transplanted to the degenerated rat intervertebral disc. Materials and Methods Rats aged 2 weeks were selected and sacrificed by breaking the neck. The bone marrow stroma stem cells of the rats were separated, cultured, detected for their adherence rate, growth, and diving. The Wistar rats aged 8 weeks were divided into four groups at random with 15 rats for each group. Each group was further divided into three subgroups with five rats for each subgroup. Experimental animal models were established. The three subgroups of animals were sacrificed at appropriate time, respectively, observed for morphological changes of the intervertebral disc tissue under a light microscope, and immunohistochemically detected for expression of type I collagen in the fibrous rings. Results Primary culture and continuous culture indicate that the bone marrow stroma stem cells of the rats have an active proliferation and multiplication capacity. Hematoxylin and eosin staining indicates that group A is the normal group and the intervertebral disc shape is regular during various periods of time; in group B, the intervertebral space becomes narrow and the fibrous rings are arranged irregularly; in group C, the intervertebral space of the specimens is becoming narrow and the fibrous rings are arranged irregularly in an early stage; the histological changes of various periods of time are consistent with that of group B. An immunohistochemical qualitative analysis on the fibrous ring type I collagen indicates that the expression of fibrous ring type I collagen is more in group A and the expression of the fibrous ring type I collagen in group B is decreasing. In group C, the intervertebral disc structure is damaged and the expression of type I collagen in the fibrous rings decreases. In group D, the morphology of the fibrous rings and expression of type I collagen during various periods of time are similar to that of group B indicating that the alginate serves as a carrier for the stem cells and does not play a role in repairing the intervertebral disc. Conclusion The degeneration of the intervertebral disc may be delayed or the degenerated intervertebral disc repaired after the bone marrow stromal stem cells are transplanted to the degenerated rat intervertebral disc. Disclosure of Interest None declared

Tarsal Coalitions: Radiographic, CT, and MR Imaging Findings.

Tarsal coalitions affect up to 13% of the population and can be a cause of chronic ankle and hindfoot pain. They can be subdivided as osseous, cartilaginous, or fibrous types, each with unique radiographic, CT, and MR imaging findings. In particular, MR imaging offers the unique ability to determine the exact type of tarsal coalition that is present as well as whether any associated soft tissue abnormalities are present. The purposes of this paper were to (1) review the anatomy of the hindfoot; (2) review the radiographic, CT, and MR imaging findings of tarsal coalitions; and (3) review the imaging appearance of the specific types of tarsal coalitions. Online searches were performed using Google Scholar with the search criteria of "tarsal coalition," "hindfoot anatomy," and "subtalar coalition," and limiting the searches to papers published in the last 10years in major radiology journals. The anatomy of the hindfoot is complex but essential to understand. There are various radiographic, CT, and MR imaging findings that can be consistently noted in cases of tarsal coalition. The specific types of tarsal coalition demonstrate characteristic imaging findings. Knowledge of the normal anatomy of the foot, in particular the hindfoot, combined with the knowledge of the imaging characteristics of different histologic subtypes of coalitions (osseous, cartilaginous, and fibrous) is essential for interpreting radiographic, CT, and MR images of the ankle and foot.

Multiple faces of children and juvenile meningiomas: A report of single-center experience and review of literature

ObjectivePediatric meningiomas are extremely rare tumors often associated with various medical conditions. This report is an attempt to analyze the clinical behavior, pathological presentation and recommended management of both isolated and neurofibromatosis type 2 (NF2) related pediatric meningiomas in comparison to their adult counterparts. MethodsThe investigated group consisted of three male and six female patients suffering from meningiomas of the central nervous system, who were hospitalized at our department in years 2001–2012. ResultsIn our group three children were diagnosed with NF2. Two were released with a suspicion of that disease. Three patients had multiple meningiomas at the first presentation. The most common manifestation were focal neurological deficits (47%). Meningiomas were mostly located at the brain convexity (29%). Histological examination revealed the domination of fibrous type in our group (29%). Apart from surgical management a preoperative embolization of the tumors' vessels was implemented in two children. Another three children underwent postoperative radiotherapy (RTh), one received a chemotherapy (ChTh). ConclusionMeningiomas in children differ from their counterparts in adults. Due to common coexistence of pediatric meningiomas and neurofibromatosis type 2, this group of patients should be taken under strict control, because of high risk of tumor recurrence.

A surgical case of primary pulmonary synovial sarcoma confirmed by the detection of an SYT-SSX1 fusion gene

We present a case of primary pulmonary synovial sarcoma in a 41-year-old female. A well-defined round nodule was pointed out in her right upper lobe on routine chest X-ray and computed tomography. Fluorodeoxyglucose positron emission tomography (FDG-PET) showed mild uptake with a maximum standardized uptake value of 2.5 at the lung nodule. No other abnormal FDG uptake was detected. As our preoperative diagnosis was benign lung tumor, we performed partial lung resection. However, the pathological diagnosis was a malignant tumor which consisted of spindle cells with very high mitotic activity. We suspected synovial sarcoma by the result of histological findings and immunohistochemical examination. Finally, an SYT-SSX1 fusion gene transcript was finally detected by reverse transcriptase polymerase chain reaction analysis. On the basis of these findings, we diagnosed primary pulmonary synovial sarcoma of monophasic fibrous type. Then completion right upper lobectomy was performed, she is alive and has been disease-free for 2 years.

Middle subtalar osseous coalition with associated fusion of the sinus tarsi: a previously undescribed type of tarsal coalition

Tarsal coalitions affect up to 13% of the population and may cause chronic ankle and hindfoot pain. Coalitions can be subdivided as osseous, cartilaginous, or fibrous types. The most common type of tarsal coalition involvesthe talocalcaneal joint, where it usually affects the middle subtalar joint. In this article, we describe a previously unpublished form of talocalcaneal coalition with osseous coalition at the level of the middle subtalar joint with associated fusion of the sinus tarsi.

AB0179 An innovative histological classification of rheumatoid synovitis and its relationship to clinical disease activity and joint destruction

BackgroundRheumatoid arthritis (RA) is a heterogeneous disease and subtyping of RA may help optimal therapeutic strategies and outcome prediction. However, there has been no available satisfying classification method till now....