Fibroma Research Articles

Desmoplastic Fibroma: a benign neoplasm mimicking a malignancy

A four-year-old African male patient presented to our clinic with a two-month history of a fi rm, warm lesion involving the right side of his face. The lesion presented as a bleeding papillary mass in the 85/46 region that extended to the floor of the mouth, causing displacement of the tongue (Figure 1A-B). Upon cone-beam computed tomography (CBCT) examination, an expansile homogenous intermediate density lesion was noted with complete destruction of the bucco-lingual cortical bone. Discernible extensions were identified in the anteroposterior plane from the region of the 84 to the posterior mandible involving the right corpus, developing 46, angle and ramus but spared the condyle and coronoid processes. The lesion extended inferiorly below the epiglottis and showed a reduction of the hypopharynx. Marked bucco-lingual expansion with soft tissue swelling was noted (Figure 2A-D). An incisional biopsy was performed under general anaesthesia, and histological examination rendered a diagnosis of desmoplastic fi broma (DF).

Ameloblastic fibro-odontoma of mandible

Ameloblastic fibro-odontoma (AFO) is a rare benign odontogenic tumor. It is considered under the category of ameloblastic fibroma which is believed to be a true mixed tumor, in which both the epithelial and the ectomesenchymal elements are neoplastic in the latest World Health Organization classification. We present a case of 10-year-old male with a left mandibular mass which was diagnosed as AFO due to its characteristic histology.

Patho-Morphological and AgNOR based Diagnosis of a Fibroma in a Camel

Patho-Morphological and AgNOR based Diagnosis of a Fibroma in a Camel

The nephrogenic adenoma of the bladder: 8 cases and literature review

Objective To analyze the clinical characteristics of nephrogenic adenoma of the bladder. Methods The clinical and pathological data of 8 patients with bladder nephrogenic adenoma, during the period from July 2016 to June 2019, were retrospectively analyzed. Patients’ age were 33 to 71 years old and the average age was 55, including 5 males and 3 females. The clinical manifestations were hematuria in 7 cases, urinary tract irritation in 6 cases, and no obvious symptoms in 1 case. There were 7 cases with cystitis, 3 cases with urolithiasis, 2 cases with bladder cancer, 1 case with invasive colonic mesentery fibroma, and 1 case without other complications. 5 cases had the history of urological operation. The predilection site was the lateral wall with 5cases; 5 cases were solitary; the average maximum diameter of the tumor was 0.9 cm (range 0.1-1.8 cm). Under cystoscope, papillary mass can be seen, the surface is bright red, the pedicle is not obvious, the papilla is thick and short, easy to bleed when touching; some of them are scattered and lichen like changes. All patients received transurethral resection of bladder mucosa. Results Pathological examination shows that the bladder mucosa showed chronic inflammation, interstitial edema, granulation tissue hyperplasia, eosinophil infiltration and metaplasia of mesonephroid epithelium. All of the 8 patients were followed up by telephone for 2 to 38 months, with an average of 17.1 months. So far, neither recurrence has been detected. Conclusions The diagnosis of nephrogenic adenoma of the bladder depends on pathological examination. It must be totally removed during operation. The recurrence and malignancy should be treated in time after operation. Key words: Urinary bladder neoplasms; Nephrogenic adenoma; Pathology

A case report on the excision of irritational fibroma using the diode laser

Irritational fibroma is a commonly occurring oral lesion, which may mimic many other pathological conditions. In this case report, we present a case of a 15-year-old male with an ill-defined overgrowth on the gingiva which was diagnosed with an irrational fibroma due to the presence of calculus. This was then excised using biolase laser, and uneventful healing was noted postoperatively. The advantage of laser over conventional treatment is that it helps in better precision, clean surgical field, and lesser postoperative complications.

Desmoplastic fibroma of the scapula: A case report and review of literature

Desmoplastic fibroma (DF) of the bone is a very rare benign tumor of the skeletal system with a reported incidence

Nonossifying Fibroma

Nonossifying Fibroma

Clinical value of peripheral blood CD62P and CA153 in diagnosis of breast cancer

Objective To study the expression of CD62P and carbohydrate antigen 153 (CA153) in peripheral blood of patients with breast cancer, and to explore the value of CD62P and CA153 in the diagnosis of breast cancer. Methods The CD62P ratio in peripheral blood of 60 patients with breast cancer (breast cancer group), 52 patients with breast fibroma (fibroma group) and 25 healthy volunteers (control group) was detected by flow cytometry (FCM). The serum CA153 level was detected by electro chemiluminescence (ECLIA), and the relationship between their expression levels and clinicopathological factors of breast cancer patients was analyzed. The sensitivity and specificity of serum CD62P, CA153 and their combination in the diagnosis of breast cancer were analyzed by receiver operating characteristic (ROC) curve. Results ⑴ The expression levels of CD62P and CA153 in breast cancer group were significantly higher than those in fibroma group and control group (P 0.05). ⑵ The expression levels of CA153 and CD62P in peripheral blood of breast cancer group were correlated with clinical stage and lymphatic metastasis (all P<0.05), and the expression levels of CA153 and CD62P were positively correlated (r=0.514, P<0.05). ⑶ The sensitivity and specificity of combined detection of CD62P and CA153 for breast cancer were higher than those of single detection. Conclusions CD62P is highly expressed in peripheral blood of patients with breast cancer, which may be a new marker for the diagnosis of breast cancer. Key words: Breast neoplasms; Flow cytometry; P-selectin; Antigens, neoplasm

Rehabilitation nursing of a patient with pleural giant solitary fibroma with Doege-Potter syndrome

Objective To summarize the clinical rehabilitation nursing practice of a patient with pleural giant solitary fibroma with Dege-Port syndrome. Methods A preoperative and postoperative rehabilitation nursing of a patient with low pulmonary function pleural giant solitary fibroma and non-islet cell hypoglycemia was analyzed and summarized. Results After psychological, hypoglycemia, and pulmonary rehabilitation, the patient was tolerant to surgery and recovered well after surgery. He was discharged from hospital on the 13th day after surgery. Conclusions For patients with difficult diagnosis, long-term pleural giant solitary fibroma with hypoglycemia and low lung function, psychological nursing, hypoglycemia symptomatic treatment, pulmonary rehabilitation to improve lung function, close observation and prevention of serious complications in patients It plays a vital role in the course of the disease and rehabilitation. Key words: Solitary fibrous tumor; Rehabilitation nursing; Doege-Potter syndrome

Ossifying fibroma of mandible-a concise radiographic exploration

Ossifying fibroma of mandible-a concise radiographic exploration

Inflammatory and reactive lesions of the orofacial region in an African tertiary health setting

Background: Chronic inflammatory and reactive lesions are tumor-like hyperplasia that are produced in association with chronic local irritation or trauma. These proliferations are painless pedunculated or sessile masses in different colors, from light pink to red. The surface appearance is variable from nonulcerated smooth to ulcerated growth, and they from a few millimeters to several centimeters in size. Common examples in the oral cavity include pyogenic granuloma (PG), epulis, traditional clinical name for gingival reactive proliferations, Irritation fibroma, epulis fissuratum, and giant cell granulomas which could either be of peripheral or central origin. Objective: To describe the pattern of inflammatory and reactive lesions of orofacial region. Materials and Methods: A retrospective study of patients attending the oral and maxillofacial clinic between January 2006 and December 2014 was undertaken. Results: One hundred and twelve patients, comprising 61 (54.5%) males and 51 (45.5%) females were seen over the period of study. Their age ranged from 1 to 80 years with a median age of 26.5 years. PG was the most frequently reported lesion accounting for 32 (28.6%). This was followed by nonspecific chronic inflammation (n = 23; 20.5%), epulis/peripheral giant cell granuloma (n = 13; 11.6%), granulation tissue (n = 10; 8.9%), and central giant cell granuloma, (n = 8; 7.1%). Conclusion: The results of the study show that inflammatory and reactive lesions are common in the study population.

Peripheral ossifying fibroma: A series of four cases

Peripheral ossifying fibroma: A series of four cases

Fibroma ossificante central: relato de caso

Introdução: O Fibroma Ossificante Central é um tumor verdadeiro benigno, raro, que necessita da combinação dos exames clínicos, radiográficos e histopatológico para ser diagnosticado. Essa lesão é assintomática, mas pode apresentar um grande volume causando assimetria facial. Pode ter comportamento agressivo e surge da membrana periodontal onde contém células multipotentes capazes de formar cemento, osso lamear e tecido fibroso. Nos maxilares, envolve com mais frequência a mandíbula e pode haver deslocamento dentário. O tratamento é feito por enucleação cirúrgica. Detalhamento do caso: O presente trabalho relata um caso clínico de um Fibroma Ossificante Central na mandíbula, focando nas suas características clínicas, imaginológicas e histopatológicas e no tratamento, assim como revisar a literatura sobre o tema. A paciente procurou atendimento se queixando do aparecimento da lesão após a exodontia de um dente. A lesão teve como diagnóstico Fibroma Ossificante Central, o tratamento foi a cirurgia por enucleação e a reconstrução da mandíbula foi feita com placa e parafusos de titânio. A paciente teve um bom prognóstico e não houve recidiva até o presente momento. Discussão: Na comparação radiográfica, apresenta-se, dependendo do estágio de desenvolvimento, bem delimitada com limites bem definidos. Neste caso, constatou-se uma lesão de limites difusos, o que é contraditório com a literatura.

Ovarian theca fibroma induced Meigs syndrome: a case report

Ovarian theca fibroma induced Meigs syndrome: a case report

A case of a huge solitary fibroma of lacrimal sac

A case of a huge solitary fibroma of lacrimal sac

A case of tuberous sclerosis induced by a somatic mosaic mutation in the TSC2 gene

Objective To investigate clinical features and detect mutations in a case of tuberous sclerosis complex (TSC) caused by a somatic mosaic mutation in the TSC2 gene. Methods Peripheral blood samples were obtained from a patient with suspected TSC, his parents, and 200 unrelated healthy controls. Genomic DNA was extracted from these blood samples, polymerase chain reaction (PCR) and next-generation sequencing were performed to amplify all the exons and their flanking sequences of the TSC1 and TSC2 genes followed by DNA sequencing, so as to identify mutations in the TSC1 and TSC2 genes. DNA was also extracted from lesional skin tissues of the patient, and PCR was conducted to amplify the target fragment of the TSC2 gene followed by DNA sequencing. Results The patient clinically presented with facial angiofibroma, depigmented patches on the waist, periungual fibroma and angioleio-myolipoma of the kidney, which were consistent with the diagnosis of TSC. A mutation c.5130_5131insT (p.V1711Cfs*18) was identified in the TSC2 gene in the patient. A higher frequency of the mutation was found in the DNA of the tumor tissue than in that of the peripheral blood. No such a mutation was found in his parents′ DNA, unrelated healthy controls or any public database. Conclusion The somatic mosaic mutation c.5130_5131insT in the TSC2 gene is responsible for the phenotype of TSC in the patient. Key words: Tuberous sclerosis complex; Mosaicism; TSC2 gene

Immunohistochemical expression of myofibroblasts, TGF-β1 and IFN-γ in oral fibrous lesions

ObjectiveAnalyze the presence of myofibroblasts (MFBs) in oral fibrous lesions and investigate TGF-β1 and IFN-γ expression by immunohistochemistry during their differentiation. DesignTwenty giant cell fibromas (GCFs), 20 fibromas (FIBs), and 20 fibrous hyperplasias (FHs) were selected. To evaluate the presence of MFBs, anti-α-SMA-immunoreactive cells were quantified in connective tissue. TGF-β1 and IFN-γ expressions were evaluated in epithelial and connective tissue by determining the percentage of immunoreactive cells. ResultsHigher MFBs concentrations were observed in GCFs (median of 20.00), followed by FHs (15.00) and FIBs (14.00) (P = 0.072). No significant correlation between TGF-β1 or IFN-γ immunoexpression and the number of MFBs in oral fibrous lesions was observed (P > 0.05). ConclusionsThe higher density of MFBs found in GCFs, followed by FHs and FIBs, reaffirms the fibrogenic role of these cells, while the higher concentrations detected in GCFs, including evidence of giant MFBs, also suggest a role in the neoplastic behavior of these lesions. No correlation was observed between TGF-β1 and IFN-γ in the myofibroblastic transdifferentiation process of the analyzed lesions.

Trabecular juvenile ossifying fibroma of the mandible

Trabecular juvenile ossifying fibroma of the mandible

Management of an elevated soft-tissue lesion with diagnosis of capillary hemangioma

Capillary hemangiomas are considered one of the rare benign oral tumors. Hemangioma of oral cavity is rare; accordingly, the present study aims to report a rare case of hemangioma that it is clinical sign representing mucocele and irritation fibroma, but the histologic results obtained from excisional biopsy led to the diagnosis of capillary hemangioma happening in the lower lip, in which the benign endothelial cell neoplasms are typically absent at birth but have a drastic development in childhood years with a natural involution in the later years of human life. In contrast to other human vascular malformations, related clinical reports have rarely mentioned its occurrence in the lower lip.

Long-term efficacy of endoscopic treatment for patients with gastric submucosal tumor

Objective To study the value of endoscopic treatment for patients with gastric submucosal tumor (G-SMT). Methods The data of 1 663 patients with G-SMT undergoing endoscopic treatment was retrospective reviewed from January 2008 to December 2013. Patients′ demographics, treatment outcomes, and follow-up were evaluated. Results A total of 1 671 lesions of G-SMT were included in the study. The mean maximum size of lesions was (1.50±1.02) cm. Twenty lesions were treated by endoscopic mucosal resection, 296 lesions by endoscopic submucosal dissection (ESD), 7 lesions by ESD+ nylon endoloop, 1 011 lesions by endoscopic submucosal excavation, 44 lesions by submucosal tunneling endoscopic resection, and 285 lesions by endoscopic full-thickness resection. Endoscopic treatment failed in 8 cases. Postoperative pathology diagnosis included 554 liomyoma, 485 gastrointestinal stromal tumors, 160 ectopic pancreas, and other such as lipoma, neuroendocrine tumor and fibroma. There were 16 cases of bleeding and 18 cases of perforation after treatment. Except for 4 cases of bleeding and 2 cases of perforation underwent additional surgical procedures, all patients were managed by conservative treatments. During a median follow-up time of 36 months of 1 226 cases, the recurrence rate was 1%(12/1 226), and no death occurred. Conclusion Endoscopic treatment is safe and effective in treating G-SMT for long-term outcomes. Key words: Stomach neoplasms; Endoscopes, therapy; Validation studies; Safety; Submucosal tumor