Fibro-osseous Lesions Of Jaws Research Articles

Spectrum of fibro osseous lesions of jaw: An institutional study

Fibroosseous lesions (FOLs) of craniofacial complex are poorly defined but pathologically diverse group of conditions. FOLs are represented by variety of disease processes mimicking clinically and histopathologically as neoplasms, developmental dysplastic lesions or inflammatory reactive process leading to difficulties in diagnosis and hence clinicopathological correlation is required.To analyse fibro osseous lesions for demographic details and clinicopathological correlation.26 cases of clinicopathologically diagnosed FOLs such as fibrous dysplasia, ossifying fibroma and cherubism were studied from archives of the Department over a 14yr period (2009 to 2022) and clinicopathologically reviewed.In retrospective study 26 cases of FOLs showed that FOLs are more commonly seen in second decade of life with female predilection and mandible is most commonly affected. Amongst these ossifying fibroma is found to be most common in our study 46% (12/26) as compared to fibrous dysplasia 42% (11/26) and Cherubism 12% (3/26).In the present study FOL were slightly more prevalent in females than male, affecting individuals below 30 years of age. Our data showed several overlapping epidemiological and clinicopathological features. Thus combination of different modalities seems to be necessary for an accurate diagnosis.

Case Report and Literature Review of Juvenile Ossifying Fibroma and Differentiating It from Other Fibro-Osseous Lesions of Jaws

Juvenile ossifying fibromas (JOF) are rare, locally aggressive tumours with high potentials of recurrence, most commonly affecting children and young adults. Trabecular and psammomatoid types are the two distinctive variants found.The psammomatoid is a rare variant, affecting paranasal sinuses and orbits. It'saetiology remains unknown and it is characterized by substitution of normal bone by mineralized fibrous tissue. These lesions are usually asymptomatic, well defined clinically and radiologically amenable for enucleation. It is often confused with malignant condition because of its clinical behaviour. CT-scans and preoperative biopsy play an important role. It is distinguished from other fibro-osseous lesions primarily by its age of onset, clinical presentation and aggressive behavior. It is a well-demarcated lesion that differentiates it from fibrous dysplasia. The treatment of choice is a surgical resection.In specific locations, it poses a great treatment challenge so that early diagnosis and multidisciplinary treatment are crucial to improve the prognosis and delay clinical sequelae. Long term follow-up is necessary, considering the high recurrence nature of this tumour. Reported here is a case of a massive juvenile ossifying fibroma of the maxilla in a 26 years old female. A titanium mesh was used to reconstruct the facial contour and orbital floor after surgical resection of involved maxilla, achieving a satisfactory facial appearance.

Cemento-ossifying fibroma: Case report

Ossifying fibroma (OF) is a benign, non-odontogenic tumor of the jaw, and it is classified as fibro-osseous lesion of jaw. Earlier, the lesion was sub classified histologically into ossifying fibroma and cementifying fibroma according to the hard tissues formed either bone or cementum. Menzel in 1872 called it as cemento-ossifying fibroma (COF). This lesion is included in the group of mesodermal odontogenic tumors and usually present as a gradually growing lesion that might achieve enormous size with resultant deformity, if not treated. The tumor may grow quite extensively; thus, the term “aggressive” is occasionally applied. In this article, A case of cemento-ossifying fibroma involving the left side of mandible is described in a 25 year-old female patient. The clinical, radiographic, histologic features are described and several differential diagnoses are discussed.

Diagnostic and Biological Significance of Immunohistochemical Expression of Osteopontin and Ki67 in Fibro-osseous lesions of jaws

Diagnostic and Biological Significance of Immunohistochemical Expression of Osteopontin and Ki67 in Fibro-osseous lesions of jaws

Fibro-osseous lesions of jaws: Analysis of three cases

AbstractFibro-osseous lesions (FOL) represent a varied group of entities in which the normal bone is replaced by cellular fibrous tissue containing mineralized foci that may vary in amount and appearance.These group of lesions predominantly affects the jaws and craniofacial bones. According to Waldron 1993, FOL includes three major groups namely fibrous dysplasia, cemento-osseous dysplasia, and ossifying fibroma. FOL show considerable overlapping in the clinical, radiographic and histological features, and so a thorough knowledge of these lesions is mandatory for interpretation and appropriate diagnosis. This article documents the clinical, radiographic and histological features of three cases of FOL and discusses the considerations related to diagnosis.

Rare example of the use of fine‐needle aspiration cytology for periapical osseous dysplasia

Osseous dysplasia (OD) is one of the fibro-osseous jaw lesions characterized by cellular fibrous tissue with hard tissue formation. We report a rare fine-needle aspiration cytology (FNAC) for periapical OD. A 34-year-old woman had well-defined, round, mixed radiolucent lesions in the periapical regions of the bilateral mandibular canines. FNAC showed hypocellular with some multinucleated giant cells and a few clusters of fibroblastlike cells. These cells had bland nuclei, with no nuclear atypia or mitotic figures. No calcified materials or bony spicules were evident. Microscopically, the lesions consisted of cellular fibrous tissue and hard tissue. The final diagnosis was bilateral periapical OD. FNAC alone may not be an accurate procedure for definitive diagnosis of a fibro-osseous lesion, but it can be a useful and reliable diagnostic method when used in conjunction with clinical and imaging findings.

Fibro-osseous lesions of the jaws: an analysis of 122 cases in Thailand

There are no previously published reports on fibro-osseous jaw lesions in Thailand. The aims of this study were to determine the relative frequencies and the clinicopathologic features of these lesions in Thailand, and to compare these data with information available in the literature. A total of 122 cases of fibro-osseous lesions of the jaws, out of a total of 4808 biopsy specimens, were collected from the files of the Department of Oral Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand, during a 34-year period from 1973 to 2006. Clinical data and histopathologic diagnoses were reviewed and analyzed. The most common was ossifying fibroma (50.8%), followed by fibrous dysplasia (42.6%). Ossifying fibroma most frequently occurred in the third and fourth decades of life (61.3%) and mostly involved the posterior region of the mandible (41.9%). Fibrous dysplasia was mostly seen in the second decade of life (40.4%). The maxilla was involved far more often than the mandible (53.8% and 6.2%, respectively), most common in the posterior region of the maxilla (28.8%). Both lesions presented as painless swellings (62.9% and 90.4%, respectively). Radiographically, ossifying fibroma mostly was mixed radiolucent-radiopacity (45.2%). Fibrous dysplasia mostly appeared as a radiopaque lesion (34.6%). The relative frequency of osseous dysplasia is underestimated because most lesions are not treated and the patients are kept under long-term follow-up without biopsy. The clinicopathologic features of ossifying fibroma and fibrous dysplasia in Thailand are identical to those in the literature.

Fibro-osseous lesions of jaws—report of five cases

Fibro-osseous lesions of jaws—report of five cases

Fibro-osseous lesions of jaw

The concept of “fibro-osseous lesions” of bone has evolved over the last several decades to include two major entities: fibrous dysplasia and ossifying fibroma, as well as other less common lesions such as florid osseous dysplasia, periapical dysplasia, focal sclerosing osteomyelitis, proliferative periostitis of Garre's, and osteitis deformans. These lesions of the jaw present multiple histologic and radiographic similarities. All fibro-osseous lesions are characterized by deposits of collagen fibres and fibroblasts with a bony or cementum-like mineralized substance in place of normal bony matrix.

Cemento-osseous dysplasia of the jaws in 54 Japanese patients: A radiographic study

Objective. The aim of this study was to describe the radiographic patterns of cemento-osseous dysplasia. Study Design. Fifty-four patients affected with benign fibro-osseous jaw lesions that showed periapical radiopacities and /or radiolucencies in a focal or a multiplex form were studied. The clinical, radiographic, and histopathologic features of the patients with cemento-osseous dysplasia were retrospectively studied. Radiographic features of the cemento-osseous dysplasia lesions were classified according to the appearance of calcified bodies. Radiographic visibility of periodontal ligament spaces of related teeth was assessed. Results. Forty-nine (91%) of the 54 patients were women. The mean age of the total group was 50.8 years, and that of the male group was 64.6 years. The cemento-osseous dysplasia lesions could be classified into 6 types radiographically. Eighteen patients had at least 2 or more types of cemento-osseous dysplasia lesions. Of 147 related teeth, 142 had periodontal ligament spaces clearly visible. Six of 9 patients who had a total of 25 teeth with active hypercementosis showed concomitant occurrence of other types of cemento-osseous dysplasia lesions. Biopsy specimens showed various amounts of bonelike and cementumlike tissues. Conclusions. It is likely that cemento-osseous dysplasia consists of 3 variations of a single entity, all with the same unknown cause. In one variation, the entity originates from the periodontium; in another, it is of medullary bone origin; and in the third it results from the simultaneous involvement of both tissues. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87:107-14)

Differential diagnosis of fibro-osseous jaw lesions: A histological investigation on 30 cases

A series of 30 fibro-osseous jaw lesions was evaluated for histological parameters that enable appropriate diagnostic classification. Special emphasis was laid upon the histomorphology of the lesion-jawbone interface, blending of lesional bone with adjacent jawbone being employed as the decisive factor in distinguishing between fibrous dysplasia and other fibro-osseous jaw lesions. Using this feature as a discriminative tool, other histological aspects that were useful in differential diagnosis could be identified. Fibrous dysplasia (n = 11) shows a rather uniform appearance with a constant ratio bone: fibrous tissue throughout the entire lesion; acellular mineralized particles are virtually absent. Juvenile ossifying fibroma (n = 3) is characterized by a highly cellular fibroblastic stroma and garland-like strands of cellular osteoid. Ossifying fibroma (n = 12) shows a high variability in stromal cellularity and types of mineralized material. Localized periapical fibro-osseous cemental lesions (n = 4) are histologically almost similar to ossifying fibroma although more heavily mineralized. It is concluded that there is full agreement between histology and radiology in indicating whether a fibro-osseous jaw lesion is demarcated or blends into its surroundings. Moreover, an appropriate diagnosis can be reliably made on histological grounds.

Fibro-osseous lesions of the jaws.

During the 15 years since the author's 1970 paper on fibro-osseous lesions of the jaws, the subject has continued to interest the clinician and pathologist. Several new entities have been delineated during this period, and new concepts and controversies regarding the diagnosis and management of these lesions have arisen. A classification of fibro-osseous jaw lesions that the author has found to be workable is presented, and criteria for their diagnosis and management based on the authors' experience is discussed.

Ossifying fibroma — One disease or six?An analysis of 39 fibro-osseous lesions of the jaws

Thirty-nine cases of benign fibro-osseous lesions of the jaws of which ten cases were reported as central ossifying fibromata are reviewed. Such lesions usually present in young adults with the exception of classical fibrous dysplasia which is normally first diagnosed in the second decade of life. All the lesions appear to be more common in females and with the exception of the peripheral ossifying fibroma show a prediliction for the mandible. It is argued that as there is no absolute histological distinction between bone and cementum and as cementum-like areas of calcification are seen in fibro-osseous lesions of all membrane bones the distinction between ossifying and cementifying lesions should be discontinued. It is also suggested that the benign fibro-osseous jaw lesions may represent different stages in the evolution of a single disease process.

Differential Diagnosis of Fibro-Osseous Jaw Lesions (Fibrous Dysplasia vs. Ossifying Fibroma)

Among 7 fibro-osseous changes of 25 cystic jaw lesions, two groups could be distinguished after histological revision: 1. with marked regional variations in bone formation, including areas free of bone, and 2. with relative constant ratio bone: fibrous connective tissue (about 50:50%). The four cases of the first group obligatory showed recurrances and included adults. They were classified as ossifying fibroma ( OF ). The 2. group encomprised 3 patients, all juvenile and free of recurrances, classified as fibrous dysplasia ( FD ). The small number of patients studied served as evidence for the existence of two entities (histologically as well as biologically) among monostotic fibro-osseous jaw lesions, namely ossifying fibroma ( OF ) and fibrous dysplasia ( FD ). Unter insgesamt 25 zystischen Kieferveränderungen fanden sich 7 fibro-ossäre Läsionen. Letztere konnten nach histologischer Revision in 2 Gruppen unterteilt werden: 1. mit ausgeprägten örtlichen Unterschieden der Knochenbildung und knochenfreien Abschnitten, 2. mit ziemlich konstantem Quotienten Knochen: fibröses Bindegewebe von ungefähr 50:50%. Die 4 Fälle der 1. Gruppe zeigten in jedem Fall Rezidive und umfaßten auch Erwachsene. Sie wurden als ossifizierende Fibrome (OF) betrachtet. Die 2. Gruppe bestand aus 3 jugendlichen Patienten, die keine Rezidive aufwiesen. Sie wurde der fibrösen Dysplasie (FD) zugeordnet. In diesem kleinen Untersuchungsgut von 7 Patienten zeichneten sich innerhalb der monostotischen flbro-ossären Kieferläsionen, histologisch wie auch biologisch, zwei Krankheitsbilder ab, nämlich das ossifizierende Fibrom (OF) und die fibröse Dysplasie (FD) .

Benign fibro-osseous lesions of the mandible and maxilla. A review of 35 cases.

AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Thirty-five benign fibro-osseous lesions of the mandible and maxilla in the Bantu were reviewed. Their clinical and radiographic features are very similar, and it was impossible to make a definitive diagnosis on these grounds alone. Although there was some overlap in the pathologic picture in 3 cases, in the remainder it was possible to make a definitive pathologic diagnosis of fibrous dysplasia, ossifying fibroma, or giant cementoma. There were 6 instances of chronic osteomyelitis incorrectly diagnosed clinically, and at first pathologically, as either fibrous dysplasia or ossifying fibroma. References 1 Amies, A., and Fleming, W. E.: Central ossifying fibroma of the jaws. Oral Surg. 15: 1409– 1414, 1962. 2 Bernier, J. L., and Thompson, H. C.: The histogenesis of the cementoma. Amer. J. Orthodont. 32: 543– 555, 1946. 3 Bradlev, J. L.: Multiple cementoma. J. Oral Surg. 2: 278– 282, 1944. 4 Chaudhry, A. P., Spink, J. H., and Gorlin, R. J.: Periapical fibrous dysplasia (cementoma). J. Oral Surg. 16: 483– 488, 1958. 5 Fontaine, J.: Periapical fibro-osterima or cementoma. J. Canad. Dent. Ass. 21: 10– 20, 1955. 6 Garcia, A., Jr., and Grantham, S. A.: Haematogenous pyogenic vertebral osteomyelitis. J. Bone Joint Surg. 42-A: 429– 436, 1960. 7 Gorlin, R. J., Chaudhry, A. P., and Pindborg, J. J.: Odontogenic tumors. Cancer 14: 73– 101, 1961. 8 Hamner, J. E., Scofield, H. H., and Cornyn, J.: Benign fibro-osseous jaw lesions of periodontal membrane origin. Cancer 22: 861– 878, 1968. 9 Harris, W. H., Dudley, H. R., and Barry, R. J.: The natural history of fibrous dysplasia. J. Bone Joint Surg. 44-A: 207– 233, 1962. 10 Pepler, W. J.: Ossifying fibromas and their relation to fibrous dysplasia, and other tumours. J. Path. Bact. 79: 408– 412, 1966. 11 Rabhan, W. N., and Rosai, J.: Desmoplastic fibroma. J. Bone Joint Surg. 50-A: 487– 502, 1968. 12 Reed, R. J.: Fibrous dysplasia of bone, a review of 25 cases. Arch. Path. 75: 480– 495, 1963. 13 Smith, A. G., and Zavelata, A.: Osteoma, ossifying fibroma, and fibrous dysplasia of facial and cranial bones. AMA Arch Path. 54: 507– 537, 1952. Citing Literature Volume26, Issue2August 1970Pages 303-312 ReferencesRelatedInformation