Objectives: To assess the feasibility and safety of a new technique of fiberoptic bronchoscopy (FOB) tracheal intubation (TI) with noninvasive ventilation (NIV) via an endoscopic full facial mask with two openings, in case of acute respiratory failure (ARF) temporally improved by NIV, but requiring a mechanical ventilation. Study design: Clinical, prospective, open, non-comparative trial of feasibility with direct individual profit. Patients: Sixteen patients with ARF (age : 60 ± 17 years, PaO 2 = 59 ± 16 mmHg, PaCO 2 = 64 ± 26 mmHg, PaO 2/FIO 2 = 142 ± 70 before NIV) (m ± SD), requiring TI. Including were : TI necessity (SpO 2 < 90 % or hypercapnic despite NIV, dependence of NIV, exhaustion, septic syndrome), clinical and SpO 2 improvement with NIV. Methods: After IV injection of 5 mg midazolam and topical anesthesia (TA) of the nose, the endoscopic mask (modified Fibroxy™, Péters) was applied to the face, fixed with elastic straps, then connected to the ventilatory support system with IPAP=20 cmH 2O, EPAP = 5 to 12 cmH 2O, FIO 2 = 1. A tube was slid on the FOB. As soon as SpO 2〚〚〚nbsp〛 94 %, the extremity of the FOB, was inserted through the lower opening of the mask, slid in the nostril, positioned in front of the glottis for AL, then pushed in the trachea authorizing AL and IV injection of 0.15 mg.kg –1 of etomidate (Ramsay〚〚〚nbsp〛3). The tube was then slid in the trachea, then, FOB was removed from trachea. Results: The FOB intubation was easy at the patientˈs, without any failure or any complication. The procedure was 6.7 ± 2 min. SpO 2 significantly improved during TI, from 84 ± 5 % (FIO 2 = 0,6 ± 3) to 97 ± 1 ( FIO 2 = 1 ± 0), without decrease in oxygen saturation off 90 %. Arterial pressure decreased only after the 5 th min. The quantities of midazolam and of etomidate used were 4.6 ± 2 mg and 12 ± 4 mg. Three patients benefited from EPAP > 10 cmH 2O. Conclusion: Fiberoptic tracheal intubation with NIV via an adapted endoscopic facial mask is a safe technique in patient with ARF temporally improved by NIV. This procedure requires TA and conscious sedation.