Currently available flexible, controlled-tip fibersigmoidoscopes for visualization of the rectum, sigmoid, and descending colon are reviewed. The technique of insertion includes patient medication and positioning, manipulation of the distal tip, rotation of the instrument, “persuasive pressure,” air insufflations, and water instillation. Insertion to 70 cm or greater was accomplished in 66% of patients. Fibersigmoidoscopy frequently provides information that influences the diagnosis and treatment in many patients with diseases of the colon and rectum.