As a key local component in heating, ventilation and air conditioning (HVAC) systems, the acoustic characteristics of the tee largely determine the indoor acoustic environment quality. The aim of this study was to determine the impact of the Helmholtz resonant cavity (HRC) on the tee noise and sound transmission loss (STL). The noise was predicted using the Ffowcs Williams-Hawkings (FW-H) equation and large eddy simulation (LES), and an analysis was conducted on four design variables: the cavity width, cavity height, outlet flow ratio, and hole width. The results indicated that increasing the hole width had a positive effect on reducing the noise of the tee. HRC could result in a tee peak noise attenuation up to 34.81 dB. In addition, based on grey model (GM) and genetic algorithm (GA) theory, the noise of the Helmholtz resonant tee (HRT) was predicted, and a noise prediction formula for resonant cavity structure paraments was derived. This study provides a new perspective for optimizing the STL of the tee and a simplified prediction method for low-noise tee design.