Central importance for the physics of strong interaction has the dynamics driven by chiral symmetry breaking in low-energy QCD. Valuable information is provided by high precision x-ray studies of the strong interaction at threshold. In this context precision measurements of the strong interaction induced energy shift and width in kaonic atoms are conducted at LNF/Italy at present and at J-PARC/Japan in the future. New dedicated experimental search for bound systems with anti-kaons are under way at GSI and will be conducted at LNF and J-PARC. These studies will provide urgently needed data for theoretical studies and will open the way to a detailed insight in the low energy regime of the strong force with anti-kaons. Especially interesting are nuclear systems involving strangeness and bound by the strong force, called kaonic nuclear clusters. At present this topic is in intense discussion and the search for these systems is conducted in new experiments (e.g. FOPI at GSI). LEANNIS, an international scientific network in Hadronphysics2 within the European Framework Program FP7, will bring together experimentalists and theorists to perform joint research work on the anti-kaon interaction with nucleons and nuclei. This presentation gives an overview on the open problems and and will present the status and outlook of research activities in this challenging field which is inherently connected with few-body physics.