Fetus Meningitis Research Articles

Campylobacter fetus seeding of a cavernous malformation resulting in brain abscess: case report and literature review.

Microbial seeding of a cerebral cavernous malformation is an extremely rare occurrence with only 3 cases reported in the literature thus far. Campylobacter fetus is an opportunistic pathogen that rarely causes neurological infection with only 3 cases of C. fetus cerebral abscesses and 38 cases of C. fetus meningitis reported in the literature. There have been no cases of cerebral cavernous malformation seeding by C. fetus reported to date. We report the first case of cerebral cavernous malformation seeding by C. fetus, a case occurring in a previously healthy 16-year-old female who presented with suspected left cerebellar cavernous malformation with subacute hemorrhage. She underwent a suboccipital craniectomy for the resection of the cavernous malformation with additional intraoperative findings suggestive of cerebral abscess. Following positive blood and CSF cultures and surgical pathology results, the patient was diagnosed with C. fetus meningoencephalitis with co-infected left cerebellar cavernous malformation. This is the fourth reported case of microbial seeding of a cerebral cavernous malformation, and to our knowledge, the first case of a C. fetus-infected cavernous malformation. Compared to previous reports, the clinical events of this case strongly support the presence of a preexisting lesion that was secondarily seeded versus de novo formation as a result of prior infection.

Méningite à Campylobacter fetus révélée par un état de mal épileptique de novo

Campylobacter fetus meningitis is a rare infection. We report the case of a patient with a bladder tumor who simultaneously developed Campylobacter jejuni gastroenteritis and Campylobacter fetus meningitis revealed by a new onset status epilepticus, hence the importance of an exhaustive exploration of the neurological manifestations occurring in immunocompromised patients.

Campylobacter Fetus Meningitis and Bacteremia in a Well-Controlled HIV Patient

We present a case of Campylobacter fetus meningitis and bacteremia in an HIV patient. He was initially admitted due to concern for meningitis. After brief observation, the patient was discharged—once infectious etiologies had been ruled out. Soon after discharge, he was readmitted due to late culture growth demonstrating Campylobacter fetus in his cerebrospinal fluid (CSF) and blood. Our patient declined initially despite being placed on an appropriate, susceptibility-proven antibiotic regimen. He was later treated successfully with carbapenem therapy. This outcome is in alignment with the few previous cases of treatment failure (despite an appropriate antibiotic regimen) and supports the argument that most patients respond best to a carbapenem regimen.

Campylobacter fetus bacteremia and meningitis in an acute lymphoblastic leukemia patient undergoing maintenance therapy: a case report

BackgroundCampylobacter fetus is an uncommon Campylobacter species, and its infections mainly cause infective endocarditis, aortic aneurysm, and meningitis rather than enteritis. It is more likely to be detected in blood than Campylobacter jejuni or Campylobacter coli, specifically reported in 53% of patients. In our case, C. fetus was detected in both blood and cerebrospinal fluid (CSF) cultures.Case presentationA 33-year-old woman, who was on maintenance chemotherapy for acute lymphoblastic leukemia (ALL), presented to our clinic with chief complaints of severe headache and nausea. Blood and CSF cultures revealed C. fetus. We administrated meropenem 2 g intravenously (IV) every 8 h for 3 weeks, and she was discharged without neurological sequelae.ConclusionWe encountered a case of C. fetus meningitis without gastrointestinal symptoms, neck stiffness or jolt accentuation in a patient with ALL. Undercooked beef was considered the source of C. fetus infection in this case, suggesting that the need for a neutropenic diet and safe food handling be considered.

Campylobacter fetus Meningitis: A diagnosis to suggest in immunocompromised patients

Campylobacter fetus causes in humans mostly gastroenteritis. Systemic infection occurs almost exclusively in immunocompromised patients with chronic debilitating diseases. We report the case of a Campylobacter fetus meningitis in a woman aged 48 years with a history of systemic lupus erythematosus treated with corticosteroids and immunosuppressive drugs. Cerebrospinal fluid culture was positive for Campylobacter fetus. The evolution was favorable using imipenem and ciprofloxacin.

Campylobacter fetus meningitis confirmed by a 16S rRNA gene analysis using the MinION nanopore sequencer, South Korea, 2016

Emerging Microbes & Infections (2017) 6, e94; doi:10.1038/emi.2017.81; published online 1 November 2017

Campylobacter fetus meningitis in an asplenic diabetic patient manifesting a chronic clinical course; case report and review of Japanese cases

We report a case of Campylobacter fetus (C. fetus) meningitis that manifested a chronic clinical course in an asplenic diabetic patient. The patient had eaten raw beef liver, and after 1 week, he suffered from headache and fever, with repeated remissions and deterioration. Four weeks after onset, neck stiffness was observed, and he was diagnosed with meningitis due to Campylobacter fetus. The cerebrospinal fluid (CSF) sample showed leukocytosis (3760/μl; neutrophils 91 %, lymphocytes 9 %). The infection responded to meropenem and ampicillin. A review of the literature between 1976 and 2013 revealed that C. fetus meningitis in adults is still a rare entity, and about one-third of case reports written in English are from Japan. We specifically reviewed the case reports of C. fetus meningitis in adults written in Japanese between 1979 and 2013 to examine the clinical features and influence of underlying disease, especially diabetes mellitus. Unexpectedly, most patients with C. fetus meningitis manifested a chronic clinical course, and CSF samples showed lymphocyte-predominant leukocytosis in at least 25 out of 43 cases. Antibiotic treatment, especially with carbapenem, was effective, and the overall prognosis of C. fetus meningitis was good, but 3 out of 43 patients had after effects. Two of the patients had diabetes mellitus as an underlying disease.

Campylobacter fetus Meningitis in a Patient with Crohnʼs Disease

Campylobacter fetus Meningitis in a Patient with Crohnʼs Disease

Epidemiologic application of pulsed-field gel electrophoresis to an outbreak of Campylobacter fetus meningitis in a neonatal intensive care unit.

An outbreak of nosocomial Campylobacter fetus meningitis occurred in a neonatal intensive care unit (NICU). Eight C. fetus strains were isolated from 4 infants with meningitis, the mother of the index patient and 2 infants who were asymptomatic intestinal carriers. The pulsed-field gel electrophoresis (PFGE) pattern with the restriction endonucleases Smal and Sall were found to be identical for the nosocomial C. fetus isolates, but the patterns were different from those of sporadic strains. These nosocomial strains were strongly suspected to be a single strain. The finding revealed that the index patient was infected by the mother, and that the outbreak developed from this patient by cross-infection. This is the first confirmed nosocomial C. fetus meningitis outbreak spread by cross-infection in a NICU.

Campylobacter fetus subspecies fetus meningitis with chronic alcoholism and diabetes mellitus.

A case of Campylobacter fetus subspecies fetus meningitis is reported. The patient had underlying diseases, namely chronic alcoholism and diabetes mellitus. The infection did not respond to Piperacillin and Cefotaxime, but did respond to Ampicillin and Moxalactam. The patient was discharged on the 33rd hospital day showing no neurological deficit complications, and has remained free of recurrent disease for one month after the discontinuation of therapy.

In vitro evaluation of antibiotics for treatment of meningitis caused by Campylobacter fetus subspecies fetus.

The most appropriate choice of antibiotics for therapy of C. fetus meningitis cannot be clearly stated. We investigated the first choice antibiotics for this illness by determining the minimal inhibitory concentrations and minimal bactericidal concentrations against eight clinical isolates of C. fetus

Vibrio fetus Meningo-Encephalitis

To the Editor:— The Feb 15Journaleditorial, Human Infection With Vibrio fetus ( 187 :531), based on a communication from the February 1964, Archives of Neurology , describes what was considered to be the first documented case of neonatal meningo-encephalitis due to V fetus . I should like to call your attention to Vibrio fetus Meningitis in a Newborn Infant, which appeared in the Journal of Pediatrics ( 61 :33 [July] 1962). In this communication I described a case of neonatal meningitis due to V fetus in a premature infant who expired despite antibiotic therapy. Since this organism is a common offender in the animal world, I stated that it should be kept in mind in all cases of abortion or prematurity, especially when the father has a history of contact with domestic animals. A plea was made to include V fetus in the differential diagnosis of all cases of neonatal meningitis. It