The use of balanced fertilizers in adequate amount is very important to increase crop productivity and production in Ethiopia. The study was executed to quantify maize (Zea mays L.) grain yield response to different rates of nitrogen (N), phosphorus (P), potassium (K) and sulfur (S) under balanced fertilization of other nutrients. On farm trials were conducted at seven sites on 8 farmers’ fields in Negele Arsi districts, west Arsi zone of Oromia region for three consecutive cropping seasons (2014-2016). Six rates of N, P, S and eight rates of K treatments established separately for each nutrient were laid out in randomized complete block (RCB) design with three replicates per farm. Nutrient response function modelling showed that 184, 20 and 80 kg•ha−1 were the agronomic optimum rate for N, P, and K, respectively. Mean agronomic efficiency (AE) of N, P and K were recorded at the lower rates of these nutrients, application of 46, 10 and 20 kg•ha−1 N, P and K resulted in 19.1, 61.0, and 24 kg additional grain yield•kg−1 N, P and K, respectively. Also, the mean partial factor productivity (PFP) of N, P and K were 77.6, 370 and 158 kg additional grain•kg−1 applied N, P and K respectively. Economically optimal rate (EOR) of N, P and K were 48 - 114 kg•ha−1 N with CP 8 - 3.5, 12 - 20 kg•ha−1 P with CP 18 - 4.5 and 32 - 53 kg•ha−1 K with CP 8-4, from these rates net returns of US$487.23 - 143.30, US$698.16 - 498.3 and US$359.31 - 193.63 could be obtained respectively. To conclude, application of 84, 12 and 40 kg•ha−1 N, P and K could be recommended for the production of maize.
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