The increasing human population has resulted in a rise in the use of chemical fertilizers to enhance crop efficiency and quality. However, the utilization of these fertilizers has led to significant environmental pollution and raised concerns, including the potential risk of cancer. Consequently, there is a growing need for innovative fertilizer formulations that reduce dependency on chemical fertilizers. Nanochelating, an advanced technology, offers a promising solution by synthesizing chelated nutrients with diameters smaller than 100 nm. These nanochelates have shown considerable effects on crop productivity, even at lower concentrations compared with traditional chemical fertilizers. In this hydroponic study, we investigated the effects of various concentrations of nanochelated fertilizers (NCF) using the standard formulation outlined by "Resh" (0.25×Resh, 0.5×Resh, 0.75×Resh, 1×Resh and 1.25×Resh) in the cultivation of tomato and cucumber. Control plants were treated with chemical fertilizers (CF). The NCF-treated plants exhibited improvements in fruit attributes and plant development. Notably, the addition of 0.5×Resh-NCF significantly enhanced vegetative growth, fruit quality, total soluble solids, fruit length, and diameter, and plant pigments. Cucumber and tomato plants treated with 0.5×Resh NCF, at half the strength of the CF treatment, displayed the highest yield, with tomatoes yielding approximately 2.02 times more and cucumbers yielding 3 times more than the CF treatment. CF-fed tomato and cucumber plants exhibited lower cell membrane stability and water content. Proline content, an indicator of plant stress, decreased in the NCF-treated plants but increased at the highest concentration. Furthermore, catalase and peroxidase activity increased in tomato and cucumber plants following NCF application. These findings underscore the potential of nanochelating-based fertilizers to enhance growth, productivity, and associated components while minimizing fertilizer usage in hydroponic greenhouses.