Consistency conditions of open string theories, which can be a powerful tool in open string model building, are proposed. By making use of these conditions and assuming a simple prescription for the Chan-Paton factors, open string theories in several backgrounds are studied. We show that (i) there exist a large number of consistent bosonic open string theories on Z 2 orbifolds, (ii) SO(32) type I superstring is the unique consistent model among fermionic string theories on the ten-dimensional flat Minkowski space, and (iii) with our prescription for the Chan-Paton factors, there exist no consistent open superstring theories on (six-dimensional Minkowski space-time) ⊗ (Z 2 orbifold).
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