In this study, Fermi–Walker derivative, Fermi–Walker parallelism, non-rotating frame, Fermi–Walker termed Darboux vector concepts are given for Lie groups in E4. First, we get any Frénet curve and any vector field along the Frénet curve in a Lie group. Then, the Fermi–Walker derivative is defined for the Lie group. Fermi–Walker derivative and Fermi–Walker parallelism are analyzed in Lie groups. Finally, the necessary conditions for Fermi–Walker parallelism are explained.