Fennel Research Articles

Ethnobotanical survey on herbal remedies for the management of type 2 diabetes in the Casablanca-Settat region, Morocco

BackgroundMorocco faces a substantial public health challenge due to diabetes mellitus, affecting 12.4% of adults in 2023. The Moroccan population makes extensive use of phytotherapy and traditional medicine to address the difficulties this chronic condition poses. The aim of this study is to document the use of medicinal plants in traditional medicine for managing type 2 diabetes in the provinces of the Casablanca-Settat region.MethodsThe study employed a semi-structured questionnaire for data collection. A study was conducted between August 1st and September 30th, 2023, and 244 individuals diagnosed with diabetes were invited to take part in the research, all of whom used at least one medicinal plant to manage type 2 diabetes, by visiting primary healthcare facilities in Morocco. The analysis included the use of Relative Frequency of Citation (RFC) to scrutinize the data.ResultsA total of 47 plant species belonging to 25 families were documented. Notably, the Apiaceae, Lamiaceae, and Fabaceae families were frequently mentioned in the context of treating type 2 diabetes in Morocco. Prominent among the cited plant species were Sesamum indicum L., Lepidium sativum L., followed by Foeniculum vulgare Mill., and Rosmarinus officinalis L. Seeds emerged as the plant part most commonly mentioned, with infusion being the prevailing preparation method and oral consumption being the most frequently depicted method of administration.ConclusionThis research underscores the practicality of incorporating traditional medicine into the healthcare framework of the Casablanca-Settat region. The findings not only offer valuable documentation but also have a vital function in safeguarding knowledge regarding the utilization of medicinal plants in this locality. Moreover, they provide opportunities to delve deeper into the phytochemical and pharmacological potential of these plants.

Valorization of ultraviolet-C (UV-C) dose validation in spices

In this work, ultraviolet-C (UV-C) radiation was applied at dose levels of 0, 0.5, 1, 1.5 and 2.0 kJ.m–2 to evaluate changes on the antioxidant capacity of dried fennel seeds, chilli pepper, and coriander seeds powder during storage. The samples’ total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydra-zyl activity, and ferric-reducing antioxidant power (FRAP) were evaluated prior to and after storage for 6 and 12 months at 25°C and a relative humidity of 45%. The results showed that spices treated with UV-C doses had significantly greater content of TPC, TFC and FRAP during storage, compared to untreated samples. The validation of UV-C dose, as investigated by the partial least squares regression analysis, stated the most valid dose for each dried spice that improved its phenolic content and antioxidant activity prior to and after storage. These findings revealed that UV-C irradiation could help alleviate losses and sustain spices’ quality and shelf life as a postharvest treatment method.

Nutraceutical Aspects of Selected Wild Edible Plants of the Italian Central Apennines

All over the world, wild edible plants are an essential source of chemical components that justify their use in folk medicine. The aim of this review is to document and summarize the knowledge of ten wild plants analyzed in a previous study for their ethnomedical significance. Achillea millefolium, Borago officinalis, Foeniculum vulgare, Gentiana lutea, Juniperus communis, Laurus nobilis, Malva sylvestris, Satureja montana, Silybum marianum and Urtica dioica were the subjects of our study. They are commonly found in the central Italian Apennines and the Mediterranean basin. Phytochemicals contained in wild plants, such as phenols, polyphenols, flavonoids, condensed tannins, carotenoids, etc., are receiving increasing attention, as they exert a wide range of biological activities with resulting benefits for human health. Based on the 353 studies we reviewed, we focused our study on the following: (a) the ethnobotanical practices and bioactive phytochemicals; (b) the composition of polyphenols and their role as antioxidants; (c) the methodologies commonly used to assess antioxidant activity; (d) the most advanced spectroscopic and spectrometric techniques used to visualize and characterize all components (metabolomic fingerprinting). The potential of pure compounds and extracts to be used as nutraceuticals has also been highlighted through a supposed mechanism of action.

Silver‐coated copper nanocomposites synthesis using the essence of Foeniculum vulgare mill and estimation of its antibacterial and cytotoxicity effects

AbstractThe Cu3.96Ag0.04 nanoparticles were synthesized using the essence of Foeniculum vulgare Mill for the first time. The particles were fully analysed by conventional characterization methods such as powder X‐ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS). The results have shown the crystal structure of silver copper particles and the crystallite size obtained by the Scherer equation was 23.2 nm. The TEM images interestingly displayed the formation of nanorods in the solid phase with nearly 5 nm widths and different lengths up to 100 nm. The hydrodynamic size is also compatible with the solid phase and crystallite sizes. Biologically, the particles were tested against infective gram negative and gram positive bacteria. The synthetic NPs show strong antibacterial properties against gram negative bacteria. Also, the synthesized nanoparticles had an inhibitory effect on the growth of cancer cells, which was dose‐ and time‐dependent.

Silver Nanoparticles as Catalysts of Foeniculum vulgare L. Callus Formation and Its Content of Vitamins and some Fatty Acids.

Plants are a precious resource of a wide range of secondary metabolites, that are benefitted as flavours, pharmaceuticals, colours, colognes, food additives and also biopesticides. The current study tested the impact of silver nanoparticles (AgNPs) on Foeniculum vulgare. Foeniculum vulgare seeds were surface sterilized, Vital leaf pieces are grown on MS media including diverse mixtures of plant growth regulators, the special effects of AgNPs plus PGRs on callus propagation were evaluated, and separated compounds of fatty acid and vitamins were identified. Outcomes revealed that several intensities of AgNPs expressively influenced the callus propagation and significantly raised the callus biomass with combination including the plant growth regulators. Highest fresh (7.32 g.L-1) biomass addition of callus was remarked on the media elevated in vitro at 20 ppm AgNPs combined with (2 mg.L-1 2,4-D) and results noted that the callus appeared compact and greenish in colour with 40 ppm AgNPs in combination with (2 mg.L-1 2,4-D). The results elucidated the amplification of the value of both fatty acids (stearic acid (47.85 %), oleic acid (189.28 %), Linoleic (6.34 %) and Linolenic (0.83 %)), and vitamins (Vitamin E (8.99 U.mg-1) and vitamin A (27.19 U.mg-1) by using MS + 2,4-D (2 mg.L-1) + AgNPs (20ppm). Application of a combination of AgNPs along with PGRs led to callus proliferation in Foeniculum vulgare L. In vitro. But, the unaccompanied use of AgNPs was originate inductive in the biosynthesis of greater quantities of special fatty acids and vitamin metabolites.

Insecticidal efficacy of some apiaceae plant metabolites against glyphodes pyloalis walker (lepidoptera: pyralidae)

Botanical based-insecticides are presently recognized to interfere behavioral and physiological performances of herbivorous insects. In the current study, the insecticidal properties of Pimpinella anisum, Foeniculum vulgare and Heracleum persicum essential oils (EOs), and their main component, trans-anethole, were studied on a destructive pest of mulberry leaves, Glyphodes pyloalis Walker. The effect of essential oils (EOs) on the larval feeding was evaluated by the leaf-dipping method and demonstrated the highest insecticidal and antifeedant activities of F. vulgare and H. persicum. Apart from negative effects on feeding indices, feeding treatment with the EOs significantly inhibited the activities of digestive enzymes and acetylcholinesterase (AChE). At nearly, all the tested compounds increased the activities of detoxifying and antioxidant enzymes. Thus, these EOs demonstrate potential as new control products to combat G. pyloalis, and they may function as an insecticide, antifeedant, or inhibitor of physiological performance.

Determination of The Fatty Acid Composition of Some Taxon of the Apiaceae Family

The aim of the study was to determine the fatty oil ratio and fatty acid components of 19 taxa, of which 6 are endemic and belong to the Apiaceae family, naturally distributed in the Isparta and Burdur provinces. In the study, the fruits of the Ammi visnaga, Angelica sylvestris, Bifora radians, Echinophora tournefortii, Echinophora tenuifolia subsp sibthorpiana, Echinophora trichophylla (endemic), Foeniculum vulgare, Ferulago cassia, Ferulago pauciradiata (endemic), Glaucosciadium cordifolium, Heracleum platytaenium (endemic), Hippomarathrum cristatum, Hippomarathrum microcarpum, Laser trilobum, Opopanax hispidus, Pastinaca sativa subsp urens, Peucedanum chryseum (endemic), Prangos platychlaena (endemic), and Prangos uechtritzii (endemic) were used as materials. The fatty oil ratios of the species were determined by NMR, and the fatty acid components were determined by the GC/FID instrument. In the study, the fatty oil ratios of the species varied from 4.0% to 27.6%. A total of 43 different fatty acids were identified, mainly palmitic acid, stearic acid, petroselinic acid, oleic acid, and cisvaccinic acid fatty acids. Most of the fatty oils of the taxa consisted of oleic acid, linoleic acid, and petroselinic fatty acids. Therefore the taxa investigated in the study are believed to be rich in fatty oil content and unsaturated fatty acids and can be used as an oil source in the future.

Effects of 70% Ethanol Extract of Foeniculum vulgare and Coleus amboinicus as a Potential Diarrhea Treatment Using Intestine Transit Method

Effects of 70% Ethanol Extract of Foeniculum vulgare and Coleus amboinicus as a Potential Diarrhea Treatment Using Intestine Transit Method

Ultrasound-Assisted Extraction of Fennel Leaves: Process optimization, Thin Layer Chromatography and Cytotoxic Activity of Ethanolic Extract

Foeniculum vulgare commonly known as fennel belonging to the family Umbelliferae, is cultivated throughout the world as a spices as well as medicinal plant possessing antimicrobial, antidiabetic, antioxidant, anti-inflammatory, …etc. A Single Factor Experiment analysis has been employed in this study to optimize caffiec acid extraction from fennel leaves by ultrasound assisted extraction method in which three variables single factor examined which were ethanol concentration, extraction time and ultrasound frequency. The study's objective was to assess the effects of variables chosen on caffiec acid's extraction performance, preliminary evaluated by thin layer chromatography (TLC) and evaluate the cytotoxic effect of optimized ethanolic extract of this plant on human breast cancer (MDA-MB-468) cell line. the experimental results revealed that the most influential extraction variables were: 80% ethanol as extraction solvent, 15 min was the time to achieve the good extraction efficacy and 40 KHz ultrasound frequency and The IC50 value of the cytotoxic effect (P < 0.05) of optimized ethanolic extract of Iraqi Foeniculum vulgare leaves on MDA-MB-468 cell line after 72 h of incubation were significantly high (46.89 µg/ml). The results of this study will be used to create a natural medicine for the symptoms of various diseases and to standardize the processes for extracting caffeic acid from natural items, particularly fennel.

Effectiveness of Foeniculum vulgare leaf essential oil nanoemulsion as a natural insecticide against Aedes aegypti larvae and mosquitoes

Abstract. Wardani AT, Kusumaningsih T, Ainurofiq A. 2024. Effectiveness of Foeniculum vulgare leaf essential oil nanoemulsion as a natural insecticide against Aedes aegypti larvae and mosquitoes. Biodiversitas 25: 990-997. The control of dengue hemorrhagic fever (DHF) was by breaking the chain of transmission by controlling Aedes aegypti larvae and mosquitoes. One alternative to controlling mosquito larvae is to use natural materials because they are more environmentally friendly and do not cause harmful residual effects. This study used a Foeniculum vulgare Mill. (fennel) leaf as a natural insecticide to kill Ae. aegypti larvae and mosquitoes. Steam distillation was done to extract essential oils from the Foeniculum vulgare Mill. leaves. F. vulgare leaf essential oil was made as nanoemulsion with tween 80, PEG 400, essential oil, and aqua demineralized. GC-MS results showed that the main ingredients in F. vulgare. leaf essential oil were anethole, estragole, bicyclo[3.1.0]hex-2-ene, 4-methyl-1-(1-methyl ethyl)-,?-pinene, cyclohexene, 1-methyl-5-(1-methyl ethenyl)-, (R)-.The current study aimed to determine the effectiveness of an F. vulgare essential oil nanoemulsion as a larvicidal, adulticidal Ae.aegypti mosquito. The study results obtained LC50 values for each formula I, II, and III were 0.098, 0.317, 0.157 µL/mL, and LC90 values for each formula I, II, and III were 0.158, 0.416, 0.245 µL/mL. Fennel leaf essential oil nanoemulsion was tested on adult Ae. aegypti mosquitoes aged 3-5 days. The results of the study obtained LC50 values for each formula I, II, III were 7.768, 10.575, 5.069 g/m3, and LC90 values for each formula I, II, III were 15.191, 27.565, 8.892 g/m3. The difference in the effectiveness of each formula may be due to the large number of essential oils in the formula. F. vulgare leaf essential oil could be an environmentally friendly natural insecticide with less residual effect.

Enhancing protection against Lasiodermaserricorne Fab. damage in seed spices using seed spice oils

Seed Spice oils of coriander (Coriandrum sativum L.), cumin (Cuminumcyminumn L.), fennel (Foeniculum vulgare Miller), and ajwain(Trachyspermum ammi L.) were used as impregnation on seed surface onsame seed as protectant against cigarette beetle Lasiodermaserricorne.All seed spice oils were able to significantly reduce the population of L.serricorneat all stages of observation. The application of fennel oil wasproved to be most detrimental against development of population of L.serricorne in fennel seed as only 11.3 beetle developed after 90 daysagainst 54.6 beetle in control treatment. Uses of higher concentration of oilapplied results more effective to reduce the population growth of beetle.The finding indicates the application of seed spice oil is good source ofrepellent for management of cigarette beetle during storage of seedspices.

Evaluation of seed yield, essential oil compositions, and fatty acid profiles in advanced fennel (Foeniculum vulgare Mill) breeding populations

Metabolites derived from bitter fennel serve as flavoring and healing agents in the pharmaceutical, food, and cosmetic sectors. Previously, we developed three fennel breeding populations (Early, Medium, and Late Maturity Synthetic Cultivars) with the potential to produce higher seed yield. This investigation aimed to assess the quality and quantity of the important metabolites in these three cultivars alongside their elite parental populations. Our results showed that the highest amounts of essential oil yield and seed yield were produced by, two breeding populations, Medium and Late Maturity Synthetic Cultivars. These cultivars showed positive seed yield heterosis rates of 28% and 20%, respectively, above the averages of their parental populations. GC-MS analysis of the essential oil samples identified 24 components in total. The major compounds in all genotypes were trans-anethole (34.09–77.84%), limonene (4.99–12.66%), methyl chavicol (1.35–38.69%), and fenchone (6–13.07%). The highest amount of trans-anethole belonged to Fasa and the Medium Maturity Synthetic with 77.84 % and 73.10%, respectively. The analysis of fatty acid compositions in the genotypes was conducted using GC-FID, which revealed the presence of 19 unique fatty acids, of which ten were saturated, and nine were unsaturated fatty acids. Petroselinic acid (67.11–78.44%), and linoleic acid (9.14–11.60%) were the major unsaturated fatty acids in fennel seeds. The Early Maturity Synthetic exhibited the least saturated fatty acid content (7.24%), while the highest levels of unsaturated fatty acids were found in both the Early Maturity Synthetic (89%) and Hashtgerd (88.55%). The genotypes were categorized into four groups using a heat map analysis with hierarchical clustering. Overall, the results showed that the three synthetic cultivars of fennel have outperformed the elite parental populations for seed and essential oil yields, concentration of the major industrial secondary metabolites such as trans-anethole, and higher proportions of unsaturated fatty acids. These cultivars show potential for usage in the pharmaceutical and healthcare industries.

Physicochemical and structural evaluation of natural products as a potential source for viral disease treatment

This research article aims to investigate six selected medicinal plants of Achillea millefolium (Yarrow), Alkanet, Rumex patientia (Patience dock), Dill, Tarragon, and Sweet fennel including some principal chemical compounds of achillin, alkannin, cuminaldehyde, dillapiole, estragole and fenchone. The definitive roles of these medicinal plants in Omicron treatment have been investigated through quantum mechanics and molecular mechanic methods. However, given the unprecedented challenges faced should be given a fair amount of consideration for contribution during this pandemic. In this work, it has been investigated the compounds of achillin, alkannin, cuminaldehyde, dillapiole, estragole and fenchone as a probable anti pandemic Omicron receptor derived from medicinal plants. Anti-Omicron drugs through the hydrogen bonding through physico-chemical properties of medicinal ingredients bound to the database amino acids fragment of Tyr-Met-His as the selective zone of the Omicron have been estimated with infrared (IR) and nuclear magnetic resonance (NMR) methods. A comparison of these structures has provided new insights for the design of substrate-based anti-targeting Omicron. Finally, five medicinal ingredients of achillin, alkannin, cuminaldehyde, dillapiole, and estragole bound to TMH have conducted to a Monte Carlo (MC) simulation for evaluating the absorbance of these inhibitor-active site complexes. Here, we used the network pharmacology, metabolite analysis, and molecular simulation to figure out the biochemical basis of the health-raising influence of medicinal plants. This research article peruses the drug ability, metabolites and potential interaction of some medicinal plants with Coronavirus-induced pathogenesis.

Protective and antidote effect of Foeniculum vulgare against Sodium Arsenite induced hepatotoxicity and testicular toxicity in Charles Foster rats

Arsenic poisoning in groundwater is the most common environmental pollutant, which is leading to serious pollution worldwide. Chronic arsenic exposure from drinking water to humans causes major public health-related issues. The present study was conducted to investigate the antidote effects of Foeniculum vulgare (Fennel) against arsenic-induced hepatotoxicity and testicular toxicity in Charles Foster rats. In the present study, twenty-four male Charles Foster rats (120±5gm) were divided into four Groups (n=6), where control Group-I received a normal diet and water; Group - II and Group - III received sodium arsenite (8 mg per kg body weight per day) for 90 days. Group III was left with a normal diet and water for the next 60 days for auto-recovery. The group IV rats were administered Foeniculum vulgare (Funnel) hydroxyl ethanolic seed extract at a dose of 150 mg per kg body weight for 60 days in a 90-day pre-treated sodium arsenite group (8 mg per kg body weight). After complete dose duration, all the treated animals were sacrificed the same day for haematological, biochemical, hormonal, and histopathological studies. In the arsenic treated rats, there were significant (p<0.001) changes in serum levels of SGPT, SGOT, urea, uric acid and creatinine as well as in haematological parameters. And there was also decease in the sperm count and sperm motility, accompanied by an increased incidence of sperm abnormalities and hormonal imbalances leading to infertility. In contrast, after the administration of F. vulgare seeds hydroxy-ethanolic extract to arsenic-treated rats, significant (p<0.001) improvements were observed in hepatic and renal parameters as well as haematological parameters. In the arsenic-intoxicant rat, after administration of F. vulgare seeds hydroxyl ethanolic extract, there was a significant (p<001) reduction in the arsenic concentration in blood, liver, and kidney tissues as well as serum LPO. The histopathological study also showed the F. vulgare seeds hydroxy-ethanolic extract significantly restored the cellular integrity of testicular cells, leading to their normal functioning against arsenic-induced toxicity.

Green synthesis of hybrids of zinc oxide, titanium oxide, and calcium oxide nanoparticles from Foeniculum vulgare: an assessment of biological activity

The increased prominence in the use of nanoparticles has made it important to employ synergy between nanoparticles while harnessing individual metallic and biological properties to improve and modify the surface, the versatility, and efficiency of nanoparticle hybrid. This study aims to conduct a bio-assessment assay of nanoparticle hybrid systems within an in-vitro set-up and improve the surface modifications of these systems. The hybrid surfaces are characterized using a scanning electron microscope, dynamic light scattering (DLS), X-ray diffraction analysis (XRD), and Fourier-transform infrared spectroscopy (FTIR). FTIR reveals the presence of functional groups like phenols, carboxylic acids, and esters. The XRD confirms the hexagonal crystalline phase of Fe-NZnO, the cubic lattice of Fe-NCaO, and the rutile phase of TiO2. The hydrodynamic diameter of Fe-NZnO-NCaO, Fe-NTiO2-NCaO, and Fe-NTiO2-NZnO are shown to be 163.2, 164.6, and 219.4 nm, respectively, using DLS analysis. Turbidity analysis indicates that Fe-NZnO-NCaO is the least aggregated particle following a 14-day observation period, meaning that it is the most stable over that period. Anti-hemolytic erythrocyte assay demonstrates the relative biocompatibility and ability of the hybrids to enhance cell protein protection. Fe-NZnO-NCaO and Fe-NTiO2-NCaO exhibit higher post-treatment cytotoxicity across the concentrations than Fe-NTiO2-NZnO.

Long-Term Monitoring of the Traditional Knowledge of Plant Species Used for Culinary Purposes in the Valencia Region, South-Eastern Spain.

The aim of this study is to inventory and study ethnobotanical knowledge of edible plants in the Valencian Community (Spain). In respect to culinary uses, 92 species of plant were reported to be edible, finding the following uses: 58 raw, 52 cooked, 16 fried, 7 dried, 21 in liquors and beverages, 25 in dessert and sweets, 11 as seasoning, 17 in pickles, and 10 to curdle milk. We prepared a database that includes genus, family, scientific, and vernacular names in Spanish and Catalan for each plant. We also created a classification of nine edible uses and plant parts used, being Asteraceae (n = 18), Brassicaceae (n = 7), Chenopodiaceae (n = 6), and Rosaceae (n = 6) the families most characterized for gastronomic purposes. The species with the most elevated cultural importance (CI) values were Foeniculum vulgare (CI = 1.389), Cynara scolymus (CI = 1.374), Papaver rhoeas (CI = 1.211), Beta vulgaris (CI = 1.167), and Juglans regia (CI = 1.155). The most used parts were the leaves (71), flowers (25), and branches (19), while the least used were roots (9) and seeds (8). Traditional knowledge of these plants helps to preserve traditional cuisine, promote the local economy and, in several species, encourage their cultivation.

Testing the Antidepressant Activity of Fennel (Foeniculum vulgare Mill) In Vitro Using the Forced Swimming Test (FST) Method

Antidepressants are a therapy used for depression sufferers with the aim of reducing symptoms, minimizing side effects and returning them to their original condition. Treatment of depression requires safe and effective therapy to prevent severity. Currently, there are many plants that have potential as antidepressants, such as fennel. The method that can be used to evaluate the effect of antidepressants is the forced swimming test (FST). 24 mice were divided into 8 groups and each group was treated with amitriptyline as a positive control, Na-CMC 0.5% as negative control and fennel infusion as test sample. The data obtained consisted of duration of immobility, climbing, and swimming which was then analyzed using SPSS with the one-way ANOVA test. The results of one-way ANOVA test for immobility, climbing, and swimming time showed that sig. values sequencely are 0.03, 0.006, and 0.016 (P< 0.05). It means that immobility, climbing, and swimming time have significant differences between group of control and treatment.

Effects of Varying Nitrogen Levels and Row Spacing on Fennel (Foeniculum vulgare mill.) Growth and Seed Yield

Effects of Varying Nitrogen Levels and Row Spacing on Fennel (Foeniculum vulgare mill.) Growth and Seed Yield

Profiling the chemical properties of Foeniculum vulgare Mill. and its flavonoids through comprehensive LC-MS/MS to evaluate their anti-motion sickness effect

Foeniculum vulgare Mill. is a medicinal and food homologous plant, and it has various biological activities. Yet, no research has explored its anti-motion sickness effects. Chemical properties of fennel extracts (FvE) and flavonoids (Fvf) were analyzed based on UPLC-QTRAP-MS to elucidate its potential anti-motion sickness components in the present study. The mice models of motion sickness were stimulated by biaxial rotational acceleration. Behavioral experiments such as motion sickness index and open field test and the measurement of neurotransmitters were used to evaluate the efficacy of compounds on motion sickness. Results showed that FvE contains terpenes, alkaloids, flavonoids, etc. Eight flavonoids including quercetin-3β-D-glucoside, rutin, hyperoside, quercetin, miquelianin, trifolin, isorhamnetin and kaempferol were identified in the purified Fvf. FvE and Fvf significantly reduced the motion sickness index of mice by 53.2% and 48.9%, respectively. Fvf also significantly alleviated the anxious behavior of mice after rotational stimulation. Among the eight flavonoids, isorhamnetin had the highest oral bioavailability and moderate drug-likeness index and thus speculated to be the bioactive compound in fennel for its anti-motion sickness effect. It reduced the release of 5-HT and Ach to alleviate the motion sickness response and improve the work completing ability of mice and nervous system dysfunction after rotational stimulation. This study provided in-depth understanding of the anti-motion sickness bioactive chemical properties of fennel and its flavonoids, which will contribute to the new development and utilization of fennel.

Polycystic Ovary Syndrome and Oxidative Stress. Natural Treatments.

Polycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathology affecting women in their reproductive ages. However, PCOS is also related to metabolic abnormalities such as metabolic syndrome (MS), insulin resistance (IR), and type 2 diabetes, among others. Consequently, an inflammatory and pro-oxidative status is also present in these patients, aggravating the syndrome's symptoms. This work aims to discuss some late treatments that focus on oxidative stress (OS) as a central feature related to primary PCOS abnormalities. Therefore, this review focuses on the evidence of anti-oxidant diets, natural compounds, mineralocorticoids, and combined therapies for PCOS management. Oxidative stress (OS) is important in PCOS pathogenesis. In this regard, increased levels of oxidative oxygen species and decreased levels of anti-oxidant agents' impact PCOS's reproductive and metabolic features. In the last years, non-pharmacological therapies have been considered a first line of treatment. For these reasons, several natural compounds such as Kelult honey (KH), Foeniculum Vulgare, Calendula officinalis Linn, Eugenia caryophyllus and Myristicafragrans, vitamin C, vitamin E, selenium, zinc, beta-carotene, magnesium, curcumin, mineralocorticoids and melatonin alone or in combination are powerful anti-oxidant agents being used for PCOS management. Data presented here suggest that natural therapies are essential in managing both reproductive and metabolic features in PCOS patients. Due to the results obtained, these incipient therapies deserve further investigation.