PurposeTo assess the postoperative outcomes of double level knee derotational osteotomy (KDRO) combined with medial patellofemoral ligament reconstruction (MPFLR), and to compare it with tibial tuber transfer (TTT) and MPFLR without derotational osteotomy in patients with recurrent patellar instability (RPI) and a marked torsional deformity. MethodsFrom March 2020 to December 2021, patients with torsion deformity (combined femoral torsion and tibial torsion ≥ 30°) were retrospectively included. The minimum follow-up time was 18 months. Patients received KDRO and MPFLR were categorized into KDRO group and patients received a combined TTT and MPFLR were categorized into control group. Preoperative and postoperative clinical symptoms, patient-reported outcomes (PROs) (Kujala, visual analogue scale [VAS], Lysholm, International Knee Documentation Committee [IKDC], Tegner, and Knee Injury and Osteoarthritis Outcome [KOOS] scores) and imaging parameters (femoral torsion, tibial torsion, patellar height, femoral trochlear dysplasia, congruence angle, patellar tilt angle, lateral patellar angle, lateral patellar translation, and tibial tubercle–trochlear groove distance) were analyzed. ResultsIn all, 36 patients were included with 18 in KDRO group and 18 in control group. The mean follow-up time was 30 (range 21-39) months. At the latest follow-up, no patient experienced re-dislocation in either group. Except for the femoral torsion and tibial torsion in the control group, postoperative imaging parameters were significantly reduced to the normal range. KDRO group has a lower patellar tilt angle (P=.043, effect size 0.64). All clinical scores in both groups significantly improved postoperatively. KDRO group has better functional scores than control group except the KOOS daily living activities subscore and the KOOS sports and recreation subscore. More proportions of patients in KDRO group met the minimal clinically important difference (MCID) for most PROs than control group. Eight patients (44%) in the control group complained of postoperative anterior knee pain, compared with 1 patient (6%) in KDRO group (P=.018). ConclusionKDRO combined with MPFLR was associated with better postoperative outcomes than TTT combined with MPFLR in patients with RPI and a torsion deformity.