This study investigates the socio-economic determinants influencing women's participation in leadership in Nyatike Sub County, Migori County, Kenya. Drawing on feminist theory and participatory development theory, the research employs a mixed-methods approach, utilizing quantitative data from 160 respondents through structured questionnaires and qualitative insights from focus group discussions with 20 key informants. The researchers identify critical socio-economic factors such as; income levels, educational opportunities, and resource access that, significantly, impact women's leadership roles. Qualitative findings underscore the importance of education and economic stability, with participants emphasizing that higher education fosters confidence in assuming leadership positions. Additionally, support systems such as women groups are pivotal in empowering women to pursue leadership roles. However, barriers such as limited access to quality education, high poverty levels, economic dependence, gender-based violence (GBV), insufficient networking opportunities, and entrenched cultural norms, hinder women's advancement in leadership. Statistical analysis reveals that 48.8% of respondents identified income level as a crucial determinant of leadership participation, followed by 22.5% citing access to social networks. Descriptive statistics indicate strong engagement in socio-economic activities, with the highest participation in mentorship and leadership development programs (mean = 4.62). The study highlights the perceived importance of public participation in promoting women's leadership, with 74.4% of respondents acknowledging its significance. These findings emphasize the need for targeted interventions that promote socio-economic empowerment, challenge gender norms, and enhance women’s leadership representation in decision-making processes. Recommendations include community-wide gender sensitization programs, educational initiatives, and enhanced mentorship opportunities to facilitate women's active participation in leadership roles.