A 30-year-old professional female triathlete has been sent to our vascular clinic for a second opinion due to exercise induced leg pain while cycling. She described a feeling of premature fatigue and cramping sensations in her left leg. These symptoms occured particularly while cycling in the aerodynamic position at maximum level of exertion and were reproducible each time after provocation of 4-5 minutes. The affected muscle groups had been identified by the patient as quadriceps, hamstrings, and calf. Similar complaints on the contralateral right side have been denied. Besides that, she suffers from an exercise-induced bronchoconstriction which is well-controlled by the application of Symbicort 400/12 Turbohaler. She is otherwise healthy. As an Olympic level triathlete she cycles around 10 000 kilometers a year. In the course of her professional career she completed approximately 80 000 kilometers on the bike (training and competitions). Finally, there is no history of premature cardiovascular disease such as myocardial infarction or strokes in under 65-year-old first-grade relatives.