Female pelvic floor dysfunction may present as urinary incontinence, uterovaginal prolapse, or rectal incontinence or prolapse. Epidemiological studies for urinary incontinence show a prevalence of between 10 and 40% of the adult female population. The incidence of uterovaginal prolapse and fecal incontinence in women presenting with urinary incontinence is 40% and 20%, respectively. MacLennan and colleagues, in a cross-sectional population prevalence survey of 1546 interviewed women aged 15‐ 97 years, found that 46% were experiencing pelvic floor dysfunction defined as stress or urge incontinence, flatus or fecal incontinence, current symptoms of vaginal prolapse or previous pelvic floor repair 1 . Pelvic floor dysfunction was associated with significant physical and mental distress upon quality-of-life assessment and was described by the authors as an epidemic. In a study by Samsioe 2 , one in three women between 55 and 75 years of age had urogenital symptoms, with 58% seeking medical help and 11% taking medications for these symptoms. Pelvic floor dysfunction is therefore a common cause of morbidity and suffering in women, so any effective preventive or therapeutic measures will make a significant contribution to improving women’ s health generally. Pelvic floor dysfunction has a multifactorial etiology, with suggested causes being pregnancy and delivery, obesity, medications, pelvic surgery, neurological impairment, excessive heavy lifting or straining, and defective collagen. The role of the menopause and estrogen loss in causation is controversial, as even good prospective epidemiological studies have difficulty in separating the importance of the various confounding etiological factors, particularly aging and the menopause. As women age, they are more likely to be more overweight, be taking medications, have pelvic surgery and be menopausal. Urinary symptoms including incontinence and uterovaginal prolapse are common in women, and increase in the 40‐ 60-year-old. Estrogen and progesterone receptors are present in the urethra, bladder, vagina and pelvic floor. Menopausal loss of estrogen results in atrophy of the urogenital tract and connective tissue changes. Some of these can be prevented or reversed by estrogen supplementation. Clinicians frequently prescribe estrogens orally, transdermally or transvaginally for urinary symptoms of frequency, urgency and urge incontinence in postmenopausal women, sometimes with short-term clinical effect 3 . Drug trials have shown a high placebo effect in women with urge symptoms. This may in part be due to the bladderretraining effect of the use of the urinary diary in assessment. The real long-term clinical benefit of estrogens for these symptoms needs further clarification. Meta-analysis of randomized trials has shown no significant improvement in urinary incontinence with estrogens, compared with placebo 4 , although most trials have been small and of short duration. The Heart and Estrogen/ progestin Replacement Study (HERS) was a 4-year randomized trial to evaluate estrogen plus progestin therapy for the prevention of coronary heart disease in high-risk patients. In this study 5 , 1525 women (55%) reported at least one episode of urinary incontinence each week, and were randomly assigned to oral conjugated estrogen (0.625 mg) plus medroxyprogesterone acetate (2.5 mg) or placebo daily and followed for
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