Dysmenorrhea or painful menstruation is defined as a severe, painful, cramping sensation in the lower abdomen that is often accompanied by other symptoms, such as sweating. headaches, nausea, vomiting, diarrhea, and tremulousness, all occurring just before or during the menses. This study aimed to assess the Knowledge and Practices of dysmenorrhea and its effect of life among female medical students in Jalalabad. Materials and Methods: A descriptive cross-sectional study was done through online Google forms for a period of 3 months from January to March 202 A structured questionnaire was administered to 173 randomly selected Undergraduate Medical students. Data were analyzed using Statistical Package for Social Sciences (SPSS) version 22.0. Objective: To gain more insight should think about dysmenorrhea is, if not it's can have alarming consequences sexual life of female. To gain knowledge about dysmenorrhea. To study and practice about dysmenorrhea increase the awareness of immature hygiene and self medication. Results: In total,173 medical students from 1st year and 2nd year were selected for this study where age range was 17-22 years with mean age of (20±1). Majority of 74% of the participants were found in to have good knowledge about dysmenorrhea. Majority of students who has good knowledge and also had good practices where as students with poor knowledge has poor practice (p value 0.021) Conclusion: Majority students concluded that dysmenorrhea is a very common problem of female students, and they experience a number of physical and emotional symptoms associated with dysmenorrhea. Mostly students are silently suffer the pain by dysmenorrhea and discomfort associated with it due to lack of knowledge about dysmenorrhea also affects their academic performance. However, their practices were found to be a matter of concern. An educational intervention can be introduced to bring about changes their life style regarding practices about dysmenorrhea among students.