Female Descendants Research Articles

Dynamics of Neospora caninum-Associated Abortions in a Dairy Sheep Flock and Results of a Test-and-Cull Control Programme.

Neospora caninum is an apicomplexan parasite that can cause abortions and perinatal mortality in sheep. Although ovine neosporosis has been described worldwide, there is a lack of information about the relationship between N. caninum serostatus and the reproductive performance. In this study, we described the infection dynamics in a dairy sheep flock with an abortion rate up to 25% and a N. caninum seroprevalence of 32%. Abortions were recorded in 36% and 9% of seropositive and seronegative sheep, respectively. Seropositive sheep were more likely to abort twice (OR = 4.44) or three or more times (OR = 10.13) than seronegative sheep. Endogenous transplacental transmission was the main route of transmission since 86% of seropositive sheep had seropositive offspring. Within dams that had any abortion, seropositive sheep were more likely than seronegative ones to have female descendants that aborted (OR = 8.12). The slight increase in seropositivity with the age, the low percentage of animals with postnatal seroconversion or with low avidity antibodies, and the seropositivity of one flock dog, indicated that horizontal transmission might have some relevance in this flock. A control programme based on selective culling of seropositive sheep and replacement with seronegative animals was effective in reducing the abortion rate to 7.2%.

Low Persistence of Genetic Rescue Across Generations in the Arctic Fox (Vulpes lagopus).

Genetic rescue can facilitate the recovery of small and isolated populations suffering from inbreeding depression. Long-term effects are however complex, and examples spanning over multiple generations under natural conditions are scarce. The aim of this study was to test for long-term effects of natural genetic rescue in a small population of Scandinavian Arctic foxes (Vulpes lagopus). By combining a genetically verified pedigree covering almost 20 years with a long-term dataset on individual fitness (n = 837 individuals), we found no evidence for elevated fitness in immigrant F2 and F3 compared to native inbred foxes. Population inbreeding levels showed a fluctuating increasing trend and emergence of inbreeding within immigrant lineages shortly after immigration. Between 0–5 and 6–9 years post immigration, the average number of breeding adults decreased by almost 22% and the average proportion of immigrant ancestry rose from 14% to 27%. Y chromosome analysis revealed that 2 out of 3 native male lineages were lost from the gene pool, but all founders represented at the time of immigration were still contributing to the population at the end of the study period through female descendants. The results highlight the complexity of genetic rescue and suggest that beneficial effects can be brief. Continuous gene flow may be needed for small and threatened populations to recover and persist in a longer time perspective.

Primordial germ cells isolated from individual embryos of red junglefowl and indigenous pheasants of Thailand

Interspecific germline chimerism mediated by transplantation of primordial germ cells (PGCs) of wild species to domestic hosts promises the conservation of wild birds. Cryopreservation of avian eggs and embryos is impracticable, and currently only frozen PGCs enable conservation of both the male and female descendants. Purebred offspring have been obtained from germline chimeras of wild avian species, proving the feasibility of such technology. In vitro propagation has been optimized for avian PGCs of domestic species; however, evidence is rather limited for successful isolation as well as long-term culture from a single embryo of wild species. With accelerating biodiversity loss, we have committed to preserving current genetic resources by freezing PGCs isolated from individual embryos in addition to their genetic material. We have devised a reliable protocol for the isolation and proliferation of PGCs from wild fowls in the family Phasianidae that are conserved in captive breeding (red junglefowl, bar-tailed pheasant, kalij pheasant, Siamese fireback pheasant, and silver pheasant). We obtained individual isolates of cultured circulating PGCs (49.7%, 79/155) as well as tissue PGCs (92.9%, 144/155). The specific co-culture conditions of autologous embryonic cells, without additional growth factors, facilitated the proliferation of so-called tissue PGCs (the remaining PGCs in embryonic tissue following blood aspiration). Only circulating PGCs left in blood vessels and of PGCs migrating to developing gonads have been previously reported. However, the present study is the first to report on the harvest of ectopic PGCs. The defined conditions sustained continuous proliferation of tissue PGCs for at least six months and maintained PGC identity following cryopreservation. Cultured tissue PGCs of these wild species were extensively characterized for their expression of the germ cell-specific proteins, chicken vasa homolog (CVH) and deleted in azoospermia-like (DAZL), as well as the ability to colonize chicken embryonic gonads. The novel protocol is practical for generating enough PGCs for cryopreservation, transplantation, and additionally, it enables isolation of PGCs from both blood circulation and embryonic tissue simultaneously. For conservation purposes, this approach is potentially applicable more widely to other non-domestic birds than those in the family Phasianidae that were investigated in the present study.

Purple grape juice consumption during the gestation reduces acetylcholinesterase activity and oxidative stress levels provoked by high-fat diet in hippocampus from adult female rats descendants.

The enzyme acetylcholinesterase participates in the end of cholinergic transmission and it has been shown that its activity is increased in some diseases that affect the brain, including Alzheimer disease. The objective of this study was to investigate the effect of purple grape juice consumption with or without high-fat diet in the gestational and lactation period on acetylcholinesterase activity and oxidative stress parameters in the hippocampus of female descendants. During pregnancy and lactation, 40 female Wistar rats received a control diet or a high-fat diet, with half of them receiving grape juice. After lactation, the female descendants received water and control diet in ad libitum until euthanasia on the 120 postnatal day. Hippocampus from were removed for analysis of AChE activity, protein oxidation and lipid peroxidation. It was observed that high-fat diet consumption during the pregnancy increased the AChE activity and the grape juice reduced this activity in descendants. The same was observed in protein oxidation, the descendants from high-fat diet had significantly highest values, and grape juice decreased the levels. We conclude that dietary choices during pregnancy can alter the acetylcholinesterase levels and grape juice is an important alternative to improve this function in adulthood.

Sex-specific plasticity across generations II: Grandpaternal effects are lineage specific and sex specific.

Transgenerational plasticity (TGP) occurs when the environment encountered by one generation (F0) alters the phenotypes of one or more future generations (e.g. F1 and F2). Sex selective TGP, via specific lineages or to only male or female descendants, has been underexplored in natural systems, and may be adaptive if it allows past generations to fine-tune the phenotypes of future generations in response to sex-specific life-history strategies. We sought to understand if exposing males to predation risk can influence grandoffspring via sperm in three-spined stickleback Gasterosteus aculeatus. We specifically tested the hypothesis that grandparental effects are transmitted in a sex-specific way down the male lineage, from paternal grandfathers to F2 males. We reared F1 offspring of unexposed and predator-exposed F0 males under 'control' conditions and used them to generate F2s with control grandfathers, a predator-exposed maternal grandfather (i.e. predator-exposed F0 males to F1 daughters to F2s), a predator-exposed paternal grandfather (i.e. predator-exposed F0 males to F1 sons to F2s) or two predator-exposed grandfathers. We then assayed male and female F2s for a variety of traits related to antipredator defence. We found little evidence that transgenerational effects were mediated to only male descendants via the paternal lineage. Instead, grandpaternal effects depended on lineage and were mediated largely across sexes, from F1 males to F2 females and from F1 females to F2 males. When their paternal grandfather was exposed to predation risk, female F2s were heavier and showed a reduced change in behaviour in response to a simulated predator attack relative to grandoffspring of control, unexposed grandparents. In contrast, male F2s showed reduced antipredator behaviour when their maternal grandfather was exposed to predation risk. However, these patterns were only evident when one grandfather, but not both grandfathers, was exposed to predation risk, suggesting the potential for non-additive interactions across lineages. If sex-specific and lineage effects are common, then grandparental effects are likely underestimated in the literature. These results draw attention to the importance of sex-selective inheritance of environmental effects and raise new questions about the proximate and ultimate causes of selective transmission across generations.

Systematic review of the differences between mothers and fathers in parenting styles and practices

Parenting is a broad construct that comprises stable and durable attitudes and behaviors regarding child-rearing. Since mothers and fathers play different roles in the family, parenting styles and practices in childhood and adolescence may differ depending on the parents’ and adolescents’ gender. While gender differences in parenting are theoretically warranted, the research literature in this field is considerably limited and lacking conclusive information dealing with this question. Therefore, the aim of this systematic review is to aggregate and synthesize the available research studies containing significant findings on the differences between mothers and fathers in parenting styles and practices. For that purpose, we conducted a systematic search of the PsycInfo, Scopus, Eric, and Web of Science databases, covering literature published from 1990 to 2020. The search was restricted to peer-reviewed studies in English alone. Our findings reveal that mothers as compared to fathers are perceived as more accepting, responsive, and supportive, as well as more behaviorally controlling, demanding, and autonomy granting than fathers. Accordingly, in the studies comparing parents on the constructs of overall parenting styles, mothers were predominantly more authoritative than fathers, and fathers were mostly more authoritarian than mothers (based on both parent and descendant reports). These parental differences established by research from over 15 countries around the globe seem to apply similarly for male and female descendants, while principally not varying by their age.

Maternal Fructose Intake Increases Liver H2 S Synthesis but Exarcebates its Fructose-Induced Decrease in Female Progeny.

Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and cardiovascular diseases (CVD). However, consumption of beverages containing fructose is allowed during gestation. Homocysteine (Hcy) is a well-known risk factor for CVD while hydrogen sulfide (H2 S), a product of its metabolism, has been proved to exert opposite effects to Hcy. First, it is investigated whether maternal fructose intake produces subsequent changes in Hcy metabolism and H2 S synthesis of the progeny. Carbohydrates are supplied to pregnant rats in drinking water (10% wt/vol) throughout gestation. Adult female descendants from fructose-fed, control or glucose-fed mothers are studied. Females from fructose-fed mothers have elevated homocysteinemia, hepatic H2 S production, cystathionine γ-lyase (CSE) (the key enzyme in H2 S synthesis) expression and plasma H2 S, versus the other two groups. Second, it is studied how adult female progeny from control (C/F), fructose- (F/F), and glucose-fed (G/F) mothers responded to liquid fructose and compared them to the control group (C/C). Interestingly, hepatic CSE expression and H2 S synthesis are diminished by fructose intake, this effect being more pronounced in F/F females. Maternal fructose intake produces a fetal programming that increases hepatic H2 S production and, in contrast, exacerbates its fructose-induced drop in female progeny.

Kafa’ah among the Hadrami Arabs in the Malay World (Anthropology of Law Approach)

This article explores how Hadrami Arabs have been maintaining the law of kafa’ah marriage or endogamy marriage in the Malay world—in this instance Indonesia and Malaysia and, to some extent, Singapore—from the early 1990s to the present. Arabs, mostly of Hadrami descent, are carrying their traditions everywhere in their diaspora. Moreover, those traditions are related to the Islamic law of endogamy marriage. This study employs a qualitative research method. Library research is used in collecting data, published or unpublished documents. Data sources are done with a web search using the following databases: Google Scholar, Ebsco-host, Research gate, Sage Journal, Scientific Electronic Library Online (SciELO), and others. The results and discussion of the research explain that the process of the establishment of the tradition of endogamy marriage has begun since their existence in Hadramaut to preserve offspring, because they became the target of the murder of the Umayyad dynasty. In Hadramaut, they established Naqabah Asyraf Kubra, which served to record the genealogy and maintain the Syarifah ((female descendants of Prophet Muhammad) in order to obey the law of endogamy marriage. On the other hand, this paper will also examine issues related to the existence of the Arab’s community diaspora in the state order in the legal perspective reviewed from the guarantee of its legal certainty. The conclusion in this study is that in the end the issue of Syarifah marriage with this akhwal depends very much on the perspective of the community either from Alawiyyin group or not. Rigid attitudes towards traditions supported by religious propositions will still be able to preserve this. However, how big is the tradition of the law of endogamy marriage able to withstand the onslaught of globalization and modernization that continues to run, because some Syarifah groups question and even break out of or disobey this tradition.

Intergenerational transmission of economic success in Austria with a focus on migration and gender

In this paper, we analyse the intergenerational transmission of economic success in Austria using the European Union Statistics on Income and Living Conditions 2011 dataset (EU-SILC 2011). Starting point of the investigation is a two-step estimation procedure, where we detect a significant positve intergenerational association between the economic situation of the parental household and educational attainments as well as gross hourly wages of their male and female descendants independently. Furthermore, we shed some light on the intergenerational social mobility black box by explaining the direct effect of the income situation of the parental generation on attainable wages of the child generation within the transmission system. It turns out that this effect is significantly underestimated when applying ordinary least squares regressions only, where the perceived socioeconomic status is taken exogenous. Finally, we apply instrumental variable quantile regressions to demonstrate that the direct intergenerational economic association between parents and their descendants is strongest for top earners. Alongside this proceeding, we introduce an alternative way to think about the impact of a bundle of additional intergenerational transmission channels like cognitive ability, noncognitive personal traits, and aspects of physical appearance on an empirical level. Overall, the findings of the paper, where special attention is paid to migrants, offer a better understanding on the intergenerational transmission of economic success mechanism and to what extent this process influences income persistence between generations.

Economic origins of cultural norms: The case of animal husbandry and bastardy

This paper explores the historical origins of the cultural norm regarding illegitimacy (formerly known as bastardy) in the context of the Habsburg Empire. We test the hypothesis that traditional agricultural production structures influenced the historical illegitimacy ratio, and have a lasting effect until today. We show that regions that focused in pre-industrial periods on animal husbandry (as compared to crop farming) had significantly higher illegitimacy ratios in the past, and female descendants of these societies are still more likely to approve illegitimacy and give birth outside of marriage today. To establish causality, we exploit for Austria, within an IV approach, variation in the local agricultural suitability, which determined the historical dominance of animal husbandry. Since differences in the agricultural production structure are completely obsolete in today’s economy, we suggest interpreting the persistence in revealed and stated preferences as a cultural norm. Complementary evidence shows that this norm is passed down through generations, and the family is the most important transmission channel. Our findings are one example for the more general phenomenon that cultural norms can be shaped by economic conditions, and may persist, even if economic conditions become irrelevant.

TRANSGENERATIONAL MODELS OF MARRIAGE: EXPERIENCE WITH GENOGRAMS

Our experiment included 72 genograms of women aged 27-34, who participated in the practical course aimed at work with generic scenarios. We analyzed women`s genograms and identified transgenerational models of marriage. Transgenerational models of marriage can be reflected in each of 3-4 generations or have some influence through generation. It should be noted that transgenerational models of marriage have the following characteristics: the structure of marriage (family hierarchy, distribution of family roles), stages of family development (divorce, move, giving birth, remarriage), the level of satisfaction with the marriage. We identified 4 transgenerational models of marriage that were frequently seen in the study sample. The 1st model “Patriarchal marriage” (14 genograms) is characterized by a significant role of a father and/or a grandfather, idealized and seen as a desired image of a man. The studied women with this family model showed some discontent with their husbands because they do not meet the expectations. The 2nd model “Matriarchal marriage” (14 genograms) is connected with strong female images (grandmother and/or great-grandmother), who were forced to take primary responsibility for the family because the man was a weak figure: he might have drunk, been sick, cheated, had problems with the law. Such relationships are very consistently reproduced in the families of female descendants. The 3rd model “Serial monogamy” (10 genograms) is characterized by the common features of two marriages from previous generations. Most often the 1st of them is described as unconscious and early, and the 2nd marriage as a more successful one. One of the options is that there are children in one marriage, and the other couple has problems with fertility. The 4th model “Misalliance” is an alliance of people with a consciously different social, educational and material status. The fact of the partners’ inconsistencies is emphasized and passed as a family mythology. This misalliance is reproduced in the generations of the descendants. Recommendations are offered for marital psychotherapy, taking into account the influence of the transgenerational model of marriage on the interactions of couples.

Genital tract and reproductive characteristics in daughters of women and men prenatally exposed to diethylstilbestrol (DES)

Prenatal exposure of women to diethylstilbestrol (DES) has been associated with reproductive tract anomalies, menstrual irregularity, infertility and pregnancy complications. In prenatally exposed men, adverse effects included genital anomalies and possible risk of infertility. In children of prenatally exposed women, i.e the third generation, an increased incidence of genital defects was observed in sons (hypospadias), but not in daughters. In daughters of prenatally exposed men, the incidence of genital anomalies was in the normal range. Experimental studies in mice evidenced an increased incidence of reproductive tract anomalies in the female descendants of females and males prenatally exposed to DES, indicative of transgenerational transmission of DES defects. The aim of this study is to assess genital tract defects, fertility and pregnancy outcome, in daughters of women and men prenatally exposed to DES. In a retrospective observational analysis, 759 daughters of prenatally exposed women and men reported their genital and reproductive characteristics that were compared with those of: 1) general population in France; 2) two cohorts of daughters of exposed women reported in previous publications; 3) women prenatally exposed to DES. An increased incidence of uterine defects was observed, with both doubling of uterus and bicornuate and aplastic uterus which constitutes the Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS). No specific anomalies described in prenatally exposed women such as T-shape or hypoplastic uterus were reported. Infertility appeared to be in the normal range. Pregnancy outcomes of our 121 pregnancies of women born to DES exposed mothers and two other published cohorts presented inconsistent results for ectopic pregnancy, miscarriage and preterm delivery. Early and late miscarriages were higher than expected in general population in our cohort but not in the two others. These results must be considered as preliminary, due to the small numbers of patients, limited follow-up duration after birth due to young age of the studied population, and observational methods. An important point is that the high risk of reproductive dysfunction of women prenatally exposed to DES was not observed in their daughters. There is a signal on the high incidence of uterine defects, especially aplastic uterus, and its possible link with DES exposure through epigenetic effects is discussed in our findings. Inconsistent findings regarding pregnancy outcomes in the third generation are worthy of further examination.

‘Educated and educating as a Black woman’ – an auto/biographical reflection on my grandmother’s influence on my academic and professional outcomes

ABSTRACT Adopting an auto/biographical approach, I discuss the impact my grandmother, Nana Elizabeth (Lizbet) Beyie had on the academic and career outcomes of myself and other female descendants. The paper begins with an exploration of Lizbet’s biography and how she overcame struggles in terms of ensuring my mother’s education in an era and context where female education was not prioritised. Following this, the paper moves to a focus on my continuation of Lizbet’s legacy though my work in academia. I reflect on my career journey and positive and challenging experiences, as a Black female academic. I discuss the value of an auto/biographical approach to exploring these issues, since it enables reflections on the relationships between structural issues (e.g. racism/sexism; the education system; Ghanaian/British society) and personal experience/action as a result, not least our decision to help educate the next generations and allows for the voices of marginalised groups (including Black women) to be heard.

KORČULANSKI STATUT I NJEGOVA NASLJEDNOPRAVNA REGULACIJA

The legal regulation of inheritance of the Korcula Statute is based on the elements of old Croatian and Slavic law and differs from the regulations in the statutes of other Dalmatian cities that are often the result of the influence of the Byzantine and later the Croatian-Hungarian Tripartite law. The basic characteristic of such a regulation, which Margetic refers to as a succesion descendent law, is the possibility that both male and female descendants inherit the estate of the deceased, but the male descendants have the advantage over women of the same degree of kinship, whereas according to Croatian-Hungarian law, women could not inherit their father’s real estate. Furtheron, the paper points out the differences regarding the legal foundations of the inheritance stipulated by the Korcula statute and other important statutes of the Dalmatian cities, and it pays particular attention to the married women’s inheritance position in terms of the disposition of their personal goods, i.e. dowry.

PRODUCTIVE LONGEVITY OF THE COWS OF UKRAINIAN BLACK-AND-WHITE DAIRY BREED UKRAINIAN DEPENDING ON HEREDITARY FACTORS

A rather low productive longevity of cows, particularly among holsteinized cattle stock, is observed in dairy husbandry of Ukraine.
 In the process of creating new dairy breeds in Ukraine, the reduction of cows’ lifespan and productive longevity along with yield increase are observed. The scientists’ research revealed the tendency to cows’ long-term performance reduction under the increasing of the genetic potential of a herd.
 It stipulates the topicality of the research as to the search of the effective genetic and selective methods of lengthening animals’ long-term performance.
 The goal of the research was to study the indicators of economic use and lifetime productivity of daughters from different bulls, as well as from different cows’ lines of Ukrainian black-and-white dairy breed.
 The research was conducted on the materials of a stud farm «Yerchyky» in Zhytomyr oblast which specializes in Ukrainian black-and-white livestock breeding, as well as on using own experimental data.
 The indices of cow economic use and lifetime productivity were determined on the ground of the term of rearing, life duration, term of economic use, amount of lactations, the total duration of lactation period, milk yields, milk yield per one lactation day, per life, and per economic use. The reasons for their disposal were determined according to veterinary disposal acts.
 The statistical data processing was done using the method of variational statistics. The power of influence of both, the paternity and the linear belonging, was determined by single-factor variance analysis.
 Having evaluated the daughters from different bulls of Ukrainian black-and-white dairy breed on a stud farm “Yerchyky”, it has been determined that daughters of Dilaita 542206 had better indices of economic use. They had both, the longest lifespan and the longest economic use, under uncertain distinction between them and the daughters from other bulls.
 The number of lactations in daughters from different bulls was low – in the range of 2.0 to 2.5. The coefficient of economic use was in the range of 48.4–50.5%.
 A long-life milk yield of daughters of Dilaita 542206 was the highest, but they had absolute advantage only above the half-sisters from stud bulls Virnyi 4975 and Klen 5221. The highest milk yield per lactation day had the daughters of Filder 5573125 (16.6 kg), which is by 2.8 kg more than the milk yield received from the daughters of Virnyi 4975, by 1 kg more than from the daughters of Dilait 5422064, by 2.9 kg more than from the female descendants of Klen 5212. 
 On a one day basis of economic use, the highest milk yield had half-sisters of Kondon bull 397111, that is by 2.2 kg more than had the daughters of Virnyi 4975, by 1.8 kg more than had the daughters of Klen 5212. Practically there is no difference as to the milk yield of daughters of Dilait 5422064 and that of Fidler 5573215. The descendants of Fidler 5573125 had the highest milk yield per one day of life.
 The parameters of economic use and of the lifetime productivity of the cows of Ukrainian black-and-white dairy breed have been studied comparing different lines.
 The longest lifespan had the cows of Starbuck line, the cows of Waliant line had the longest economic use under uncertain difference when comparing with the descendants of other lines. The number of lactations was low and ranged from 2.3 to 2.6. The coefficient of economic use of the cows of different lines was within 48.6–54.00%.
 The highest life-term milk yield had the cows of Valiant and Vis Burke Aidiala lines. These cows had the best indices of economic use and of lifetime productivity, they had the highest milk yield per one lactation day.
 By means of single-factor variance analysis it has been determined that the paternity has a significant impact on the indices of economic use as well as on a linear belonging. A reliable part of bulls influence on the duration of cultivation period makes 7.2%, on milking yield per one day of lactation – 12.6%, on one day of economic use – 4.8%, on one day of life – 4.2%. The influence of linear belonging was lower. A reliable part of linear belonging influence on the duration of cultivation period makes 2.9%, on milking yield per one lactation period – 9.5%, and on one day of economic use – 3.3%.

A maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independently of maternal mitochondrial inheritance.

Maternal obesity is correlated with cardiovascular disease in offspring, with a 1.3-fold increase in events observed in offspring of obese women. We have observed that obesity-exposed oocytes demonstrate impaired mitophagy and transmit damaged mitochondria to the offspring. Accordingly, we hypothesized that maternal obesity induces cardiac mitochondrial dysfunction in the offspring via transgenerational inheritance of abnormal oocyte mitochondria. We mated female mice fed a high-fat/high-sucrose (HFS) diet (or chow) with chow-fed males and assessed cardiac structure and function in their descendants that were chow fed in each generation. All F1 to F3 descendants bred via the female in each generation were nonobese and demonstrated cardiac mitochondrial abnormalities with crystal rarefaction and reduced oxygen consumption pointing to a transgenerational effect, while obese F0 dams' hearts were unaffected. Furthermore, male offspring from F1 to F3 generations and female F1 and F2 offspring developed increased left ventricular (LV) mass (vs. chow-fed controls). Increased LV mass was also observed in offspring generated by in vitro fertilization of obesity-exposed oocytes and gestation in nonobese surrogates, ruling out a gestational environment effect. Contrary to our hypothesis, male F1 also transmitted these effects to their offspring, ruling out maternal mitochondria as the primary mode of transmission. We conclude that transmission of obesity-induced effects in the oocyte nucleus rather than abnormal mitochondria underlie transgenerational inheritance of cardiac mitochondrial defects in descendants of obese females. These findings will spur exploration of epigenetic alterations in the oocyte genome as potential mechanisms whereby a family history of maternal obesity predisposes to cardiovascular disease in humans.

Anorexia nerviosa y psiquiatría transcultural

Se presenta el caso de una adolescente de 16 años, descendiente de una familia de origen chino, que ingresa en la Unidad de Psiquiatría Infanto-Juvenil por pérdida importante de peso e hipocalemia. Se realiza una revisión de las características de la psiquiatría transcultural y las consecuencias derivadas del proceso migratorio.

The Letter: Fidelity in Researcher Positionality to Exhume Dispossessed Voices for Leavy’s Concept of Coherence in Feminist Narrative Research

This feminist narrative research explored the fidelity of researcher positionality and Leavy’s coherence to consider an archival personal letter from the Sauk warrior Black Hawk’s great great daughter, Mary Kakaque, written to John Henry Hauberg, an Illinois philanthropist. Future research is needed to characterize Mary’s educational experiences amid an era of cultural annihilation and assimilation within the collective narrative of Hauberg’s interpretations, paraphrases, and summaries of Mary’s existence, and a phenomenological study to explore Mary’s lived experience within the full archival Hauberg collection to consider the constructs of voice or resilience as the lived experiences of Black Hawk’s female descendants remain limited. In addition, a critical ethnography may be warranted for ancestral effects of relocation and assimilation from the perspectives of living Black Hawk and Mary’s female descendants to contribute a contemporary perspective on voice, culture, and the legacy of land dispossession.

Maternal fructose induces gender-dependent changes in both LXRα promoter methylation and cholesterol metabolism in progeny

Fructose consumption from added sugars correlates with the epidemic rise in obesity, metabolic syndrome and cardiovascular diseases. However, consumption of beverages containing fructose is allowed during gestation. We have investigated whether maternal fructose intake produces subsequent changes in cholesterol metabolism of progeny. Carbohydrates were supplied to pregnant rats in drinking water (10% w/v solution) throughout gestation. Adult male and female descendants from fructose-fed, control or glucose-fed mothers were studied. Male offspring from fructose-fed mothers had elevated plasma HDL-cholesterol levels, whereas female progeny from fructose-fed mothers presented lower levels of non-HDL cholesterol vs. the other two groups. Liver X-receptor (LXR), an important regulator of cholesterol metabolism, and its target genes such as scavenger receptor B1, ATP-binding cassette (ABC)G5 and cholesterol 7-alpha hydroxylase showed decreased gene expression in males from fructose-fed mothers and the opposite in the female progeny. Moreover, the expression of a number of LXRα target genes related to lipogenesis paralleled to that for LXRα expression. In accordance with this, LXRα gene promoter methylation was increased in males from fructose-fed mothers and decreased in the corresponding group of females. Surprisingly, plasma folic acid levels, an important methyl-group donor, were augmented in males from fructose-fed mothers and diminished in female offspring. Maternal fructose intake produces a fetal programming that influences, in a gender-dependent manner, the transcription factor LXRα epigenetically, and both hepatic mRNA gene expression and plasma parameters of cholesterol metabolism in adult progeny. Changes in the LXRα promoter methylation might be related to the availability of the methyl donor folate.

Social Mobility of Royal female descendants in Early Joseon Dynasty

Social Mobility of Royal female descendants in Early Joseon Dynasty