In current practice, no special measures are applied for enhancing structural fire safety of steel bridge girders. Further, there is very limited information and research data in the literature on the fire resistance of structural members in bridges. In this paper, the fire response of a steel bridge girder under different conditions is evaluated using the FEM computer program ANSYS. In the analysis, the critical factors that influence fire resistance, namely, fire scenario, fire insulation, and composite action arising from steel-concrete interaction, are accounted for. Results from numerical studies show that the composite action arising from steel-girder-concrete-slab interaction significantly enhances the structuralperformance(and fireresistance)ofasteelbridgegirderunder fireconditions.Othersignificantfactorsthatinfluence fireresistanceof steel bridge girders are fire insulation and type of fire scenario. DOI: 10.1061/(ASCE)BE.1943-5592.0000412. © 2013 American Society of Civil Engineers. CE Database subject headings: Fires; Fire resistance; Girder bridges; Steel bridges. Author keywords: Bridge fires; Fire resistance; Steel girders; FEM analysis.