Context: Health is a multidimensional concept, denoting not only an absence of disease and disability, but also feeling of happiness and welfare. Stress is among the important factors threatening mental health, and people are faced with numerous stressors in their everyday lives. Accumulation of daily stress would affect individuals' physical and mental health, and when it lasts for long term, it can lead to negative outcomes, including neurotic and stress-related disorders. However, most individuals do not develop such illnesses after experiencing stressful life events, because the person who is resilient does not develop neurotic and stress-related disorders because this resilience shield people against the development of stress-related disorder. Aim: This study was conducted to find if there is a significant difference in the scores on measures of resilience between patients with neurotic and stress-related disorders with normal counterpart. Methods: The sample comprised 60 participants, 30 with neurotic and stress-related disorder, and 30 their normal counterpart. Participants were administered Connor–Davidson Resilience Scale (CD-RISC-25), General Health Questionnaire-12, and sociodemographic pro forma. Results: Significant differences were found in the resilience score of neurotic and stress-related disorders' patients with normal counterpart (t = 18.524, P = 0.000). Conclusion: CD RISC-25 showed the mean score of resilience among neurotic and stress-related disorders' patients were found to be 34.86 ± 9.35, and the counterpart scored the mean value of 85.66 ± 11.70 where the maximum possible score was 100. Resilience of counterpart was higher than neurotic and stress-related disorders' patients, (t = 18.524, P = < 0.000).