PurposeThis paper introduces control strategy to enhance the performance of a novel quadrotor unmanned aerial vehicle designed for medical payload delivery. The aim is to achieve precise control and stability when carrying and releasing payloads, which alter the quadrotor’s mass and inertia characteristics.Design/methodology/approachThe equations of motion specific to the payload-carrying quadrotor are derived. A feedforward-proportional-integral-derivative (FF-PID) control strategy is then proposed to address the dynamic changes during payload release. The PID components use propeller speed/orientation information for stability. FF terms based on derivatives of desired position/orientation variables enable adaptation to real-time mass fluctuations.FindingsExtensive simulations, encompassing various fault scenarios, substantiate the effectiveness of the FF-PID approach. Notably, our findings demonstrate superior performance in maintaining altitude precision and stability during critical phases such as takeoff, payload release and landing. Graphical representations of thrust and mass dynamics distinctly illustrate the payload release event. In contrast to the linear quadratic regulator (LQR) and conventional PID control, which encountered difficulties during the payload release process, our approach proves its robustness and reliability.Research limitations/implicationsThis study, primarily based on simulations, demands validation through real-world testing in diverse conditions. Uncertainties in dynamic parameters, external factors and the applicability of the proposed approach to other quadrotor configurations require further investigation. Additionally, this research focuses on controlled payload release, leaving unexplored the challenges posed by unforeseen scenarios or disturbances. Hence, adaptability and fault tolerance necessitate further exploration. While our work presents a promising approach, practical implementation, adaptability and resilience to unexpected events are vital considerations for future research in the field of autonomous aerial medical deliveries.Practical implicationsThe proposed control strategy promises enhanced efficiency, reliability and adaptability for autonomous aerial medical deliveries in critical scenarios.Social implicationsThe innovative control strategy introduced in this study holds the potential to significantly impact society by enhancing the reliability and adaptability of autonomous aerial medical deliveries. This could lead to faster and more efficient delivery of life-saving supplies to remote or disaster-affected areas, ultimately saving lives and reducing suffering. Moreover, the technology’s adaptability may have broader applications in fields like disaster relief, search and rescue missions, and industrial cargo transport. However, its successful integration into society will require careful regulation, privacy safeguards and ethical considerations to ensure responsible and safe deployment while addressing potential concerns related to noise pollution and privacy intrusion.Originality/valueWhile PID control of quadrotors is extensively studied, payload release dynamics have been overlooked. This research studies integration of FF control to enable PID adaptation for a novel payload delivery application.