The aim of this study is to provide an empirical answer to the question of whether nexus exists between climate change and sustainable agricultural growth in nine (9) countries within the Sahel region between 1990 and 2020. The study utilized Panel ARDL and Pairwise Dumitrescu Hurlin Panel Causality Tests to arrive at the following conclusions; firstly, the climate change orchestrated by change in rainfall is a very prominent factor causing reduction in sustainable agricultural growth in the Sahel region. One way feedback relationship flows from sustainable agricultural growth to greenhouse gas emission. In the light of the above, this study recommends that, in addressing the adverse effects of change in rainfall on agricultural sustainability, the policymakers in the Sahel region in particular and Africa as a whole should embark on a policy mix by embanking on mitigating policy response towards ensuring sustainable agricultural production via irrigation which is the best mode of water provisions without causing negative spilliovers on the environment. Also, the policymakers should be proactive by embarking on policies and programs that would build the resilience and adaptation of the region ahead of the future adverse effects of agriculturally induced climatic change.