Feedback Mode Research Articles

Student-teacher relationship: Written feedback provision and writing performance

Despite several studies on feedback, little is known about the benefits of the student-teacher relationship in providing feedback. This study therefore aimed to investigate the effects of teacher feedback on students' writing performance. The feedback was divided into two formats: Direct Feedback and Indirect Feedback. Students' writing performance in the study refers to the quality of students' writing when composing a descriptive paragraph. In addition, this study also explored the voices of English as a Foreign Language (EFL) students after being treated with different feedback modes under specific circumstances of the student-teacher relationship. The study adopted a mixed methods design, using a test, a semi-structured interview and a questionnaire as instruments to obtain qualitative and quantitative data. The study involved 50 secondary school students who were divided into two groups of 25 students each. The results showed that direct feedback stimulated students' writing performance better than indirect feedback. In addition, the feedback treatments could maximize students' writing performance if a good student-teacher relationship was developed in the classroom. This implies that maintaining a good student-teacher relationship in the EFL classroom is beneficial.

Wearable Haptics for Orthotropic Actuation Based on Perpendicularly Nested Auxetic SMA Knotting.

Smart wearable tactile systems, designed to deliver different types of touch feedback on human skin, can significantly improve engagement through diverse actuation patterns in virtual or augmented reality environments. Here, a perpendicularly nested auxetic wearable haptic interface is reported for orthotropically decoupled multimodal actuation (WHOA), capable of producing diverse tactile feedback modes with 3D sensory perception. WHOA incorporates shape memory alloy wires that are intricately knotted into an auxetic structure oriented along orthotropic dual axes. Its perpendicularly nested auxetic structure enables orthotropic actuation, allowing independent expansion and contraction along both x and y-axes, as confirmed by force-strain and displacement-time performance tests. Additionally, the perylene coating provides orthogonal electrical isolation to WHOA, allowing for stripe-specific localized actuation and enabling multiple tactile feedback modes. As an orthotropic wearable haptic interface, WHOA distinguishes between x-axis and y-axis directions and ultimately delivers multi-dimensional information regarding movements in 3D space through tactile feedback. As a result, when worn on the foot or arm, WHOA naturally delivers spatiotemporal tactile information to the user, facilitating navigation and teleoperation with 3D sensory perception.

Polycyclic Aromatic Hydrocarbon Emission in the Central Regions of Three Seyferts and the Implication for Underlying Feedback Mechanisms

We analyze JWST Mid-Infrared Instrument/Medium Resolution Spectrograph integral field unit observations of three Seyferts from the Galactic Activity, Torus, and Outflow Survey (GATOS) and showcase the intriguing polycyclic aromatic hydrocarbon (PAH) and emission-line characteristics in regions of ∼500 pc scales over or around their active galactic nuclei (AGN). Combing the measurements and model predictions, we find that the central regions containing a high fraction of neutral PAHs with small sizes, e.g., those in ESO137-G034, are in highly heated environments, due to collisional shock heating, with hard and moderately intense radiation fields. Such environments are proposed to result in inhibited growth or preferential erosion of PAHs, decreasing their average size and overall abundance. We additionally find that the central regions containing a high fraction of ionized PAHs with large sizes, e.g., those in MCG-05-23-016, are likely experiencing severe photoionization because of the radiative effects from the radiative shock precursor besides the AGN. The severe photoionization can contribute to the ionization and further destruction of PAHs. Overall, different Seyferts, even different regions in the same galaxy, e.g., those in NGC 3081, can contain PAH populations of different properties. Specifically, Seyferts that exhibit similar PAH characteristics to ESO137-G034 and MCG-05-23-016 also tend to have similar emission-line properties to them, suggesting that the explanations for PAH characteristics of ESO137-G034 and MCG-05-23-016 may also apply generally. These results have promising application in the era of JWST, especially in diagnosing different (i.e., radiative and kinetic) AGN feedback modes.

Exploring the Acceptance of Mobile-Assisted Peer Feedback in English Speaking among Chinese EFL Students

Grounded in the Technology Acceptance Model (TAM), this quasi-experimental study examined the use of Mobile-Assisted Peer Feedback (MAPF) tools via the Tencent Mini Programme among Chinese university EFL learners to enhance English speaking proficiency. A mixed-methods approach was employed, using descriptive statistics for questionnaire data and thematic analysis with NVivo for interview data. Sixty non-English major students (CEFR levels A2-B1) were selected through purposive sampling and assigned to three groups: one-way, dialogic, and visualised peer feedback. Results showed positive responses across all modes, with visualised feedback rated highest for usefulness, behavioural intention, and speaking improvement. The study highlights the need to consider technological, individual, and sociocultural factors in mobile-assisted feedback for language learning. Future research should explore long-term effects, application in diverse contexts, and further refinement of mobile-assisted feedback modes to enhance learner engagement. This study contributes to the research on MAPF in English speaking and offers practical insights for educational technology development.

Design and Implementation of Multi-mode Natural Interaction of Game Animation Characters in Mixed Reality: A Novel User Experience Method

To enhance users’ novel experiences in gaming, the design method of multi-mode natural interaction of game animation characters in mixed reality is studied. Through the process of skeleton modeling, interpolation of position and orientation, time alignment and time transformation of character posture, the game animation character in mixed reality is constructed. The multi-role interactive game animation is synthesized using a random graph and uniform network, and the edge of the depth of field image collected by the Kinect somatosensory sensor is extracted. According to the transfer model and observation model of the Kalman filter algorithm, the motion trajectory of the game animation characters is obtained and the game animation characters are tracked. The IRS recognition algorithm is used for optical multi-touch processing in mixed reality, and the natural interaction of multi-mode game animation characters in interaction–perception mode, natural interaction mode and interactive feedback mode is realized. The experimental results demonstrate that this method can achieve multi-mode natural interaction of game animation characters in mixed reality and provide users with a novel game experience.

Application of high-performance computing in sustainable energy campus building design

In high-performance computing (HPC) systems, energy and power considerations play an increasingly important role. This work aims to ensure the implementation of China’s green and ecological concepts, respond to China’s strategy of building an environment-friendly and resource-saving society, and actively promote the construction of sustainable development campuses. First, the theoretical basis of sustainable energy campus architecture is described. Next, the teaching feedback model under HPC is constructed. Finally, with the evaluation results of students’ task completion processes and students’ task works as measurement indexes, the corresponding data is collected and comprehensively evaluated and analyzed to verify the effectiveness of the model. The analysis results indicate that most students are able to complete tasks within two hours; however, their proficiency with multimedia technology is inadequate, and they lack initiative in the learning process. There is a correlation between the overall evaluation of task performance and the students’ level of understanding of the tasks. By implementing a teaching feedback model, students’ learning enthusiasm and the quality of their work improved, providing effective educational support for promoting sustainable development on campus. Overall, the awareness of using computers and other multimedia technologies among students is not strong, and their learning process is relatively closed, with insufficient enthusiasm and initiative. This model can achieve the acquisition, integration, and statistical analysis of teacher feedback information. The model can realize the acquisition, integration, and statistical analysis of teachers’ feedback information. This work hopes to use this learning and feedback mode in practical teaching to address specific problems in computer multimedia courses.

The effects of stellar and AGN feedback on the cosmic star formation history in the simba simulations

ABSTRACT Using several variants of the cosmological simba simulations, we investigate the impact of different feedback prescriptions on the cosmic star formation history. Adopting a global-to-local approach, we link signatures seen in global observables, such as the star formation rate density (SFRD) and the galaxy stellar mass function (GSMF), to feedback effects in individual galaxies. We find a consistent picture: stellar feedback mainly suppresses star formation below halo masses of $M_{\rm H} = 10^{12} \rm \, {\rm M}_{\odot }$ and before $z = 2$, whereas AGN feedback quenches the more massive systems after $z = 2$. Among simba’s AGN feedback modes, AGN jets are the dominant quenching mechanism and set the shape of the SFRD and the GSMF at late times. AGN-powered winds only suppress the star formation rate in intermediate-mass galaxies ($M_{\rm \star } = 10^{9.5 - 10} \rm \, {\rm M}_{\odot }$), without affecting the overall stellar mass-assembly significantly. At late times, the AGN X-ray feedback mode mainly quenches residual star formation in massive galaxies. Our analysis reveals that this mode is also necessary to produce the first fully quenched galaxies before $z=2$, where the jets alone are inefficient. These initially highly star-forming galaxies contain relatively large black holes, likely strengthening the X-ray-powered heating and ejection of gas from the dense, central region of galaxies. Such extra heating source quenches the local star formation and produces a more variable accretion rate. More generally, this effect also causes the break down of correlations between the specific star formation rate, the accretion rate and the black hole mass.

Profiling EFL writing teachers’ feedback provision practices and activity uses in Saudi universities

Understanding the realities of feedback practices and activity uses in writing classrooms is key to optimizing them. This study attempted to profile Saudi university English writing teachers’ uses of feedback delivery modes, error correction strategies, and learner-centered feedback activities. The study drew upon the qualitative approach by using an open-ended questions to explore and gain an in-depth understanding of teachers’ feedback provision practices and activity uses. Open-end questionnaire responses were collected from 74 English writing teachers working at eight Saudi universities. The results revealed that handwritten and oral feedback modes are more dominant in the teachers’ practices than electronic and audio-recorded modes. Additionally, a relatively larger number of the teachers reported using direct and comprehensive error correction strategies more than indirect and selective ones. A considerable number of the teachers were found to use combinations of feedback modes, direct-indirect and comprehensive-selective error correction forms. With regard to their use of learner-centered feedback activities, a larger number of the teachers reported making use of peer feedback in their classes but neglecting student self-evaluation and automated writing evaluation activities. The paper discusses the implications pertinent to improving feedback provision practices and activity uses in the Saudi university context.

High-throughput true random number generator based on a dual-input oscillation circuit

The rapid development in the fields of information encryption, key generation, and algorithm initialization requires an increasing rate of true random numbers, making it necessary to design a fast true random number generator. In this work, a dual-mode conversion high throughput true random number generator (TRNG) based on a dual input oscillating XOR circuit (DIO-XOR) is proposed, which is designed using DIO-XOR, combined with a MUX selects the feedback mode of the whole circuit: self-feedback/mutual feedback. It is verified by automatic layout and routing on Xilinx Artix-7 and Kintex-7 FPGAs with a throughput rate of 650Mbps, which is achieved with low hardware overhead, and passes the entropy estimation test suite, NIST SP800-90B, as well as TESTU01 with high entropy, the sequences generated in the temperature-voltage fluctuation test pass the NIST SP800-22 test with good robustness.

Label-Free Imaging of Mesenchymal Stem Cell Spheroid Differentiation with Flexible-Probe SECM and a Microfluidic Device.

Mesenchymal stem cells (MSCs) have emerged as an indispensable source for stem cell research and preclinical studies due to their capacity for in vitro proliferation and their potential to differentiate into mesodermal lineages, particularly into osteoblasts. This capability has propelled their application in the fields of bone regeneration and osteochondral repair. Traditional methodologies for assessing the differentiation status of MSCs necessitate invasive procedures such as cell lysis or fixation. In this study, we introduce a nondestructive technique that utilizes an integrated label-free approach to evaluate the osteogenic maturation of MSC spheroid aggregates. This method employs scanning electrochemical microscopy (SECM) with a flexible probe in conjunction with a top-removable microfluidic device designed for easy SECM access. By tracking the production rate of p-aminophenol (PAP) in the generation/collection mode and assessing morphological changes via the negative feedback mode using [Ru(NH3)6]Cl3 (Ruhex), we can discern variations in the alkaline phosphatase (ALP) activity indicative of osteogenic differentiation. This innovative strategy enables the direct evaluation of osteogenic differentiation in MSC spheroids cultured within microwell arrays without necessitating any labeling procedures. The utilization of a flexible microelectrode as the probe that scans in contact mode (with probe-substrate distances potentially as minimal as 0 μm) affords enhanced resolution compared to the traditional stiff-probe technique. Furthermore, this method is compatible with subsequent molecular biology assays, including gene expression analysis and immunofluorescence, thereby confirming the electrochemical findings and establishing the validity of this integrative approach.

Simulation Studies of Interfacial Kinetics of Dye-Sensitized Solar Cells Photoanodes in Scanning Electrochemical Microscopy

Approach curves in the feedback mode of scanning electrochemical microscopy (SECM) were simulated for photoanodes in dye-sensitized solar cells by finite element simulation using COMSOL Multiphysics and compared to experimental data for the sample set with varying the photoanode film thickness (ZnO, cobalt mediator, organic dye). This reveals quantitatively the effect of the mass transport limitation of the mediator diffusion and organic dye regeneration kinetics in the mesoporous photoanode. The simulation of the mesoporous material was made with a pseudo-homogeneous approach in two space dimensions.The simulation allows to extract the maximum information content from the experimental data. The light adsorption was treated as exponential decay of intensity within the photoanode (Lambert-Beer law), electron injection in the conduction band of ZnO photoanode and loss mechanism was explicitly considered. The light illumination is homogeneous over the entire simulation domain of 1 mm in diameter. Just like in the experiment, the built geometry used for the simulation has a conducting blocking layer (0.6 µm in thickness) to prevent the recombination of electrons with the back contact. The porous dye-sensitized layer has a porosity of 50 - 60% and a thickness of 1- 10 µm. The inner surface holds the dye for absorbing light. The mediator diffuses in the pore of the photoanode (internal solution) and in the bulk of the electrolyte (external diffusion). The transparent conducting glass makes the boundary of the simulation domain. The electrolyte-platinum contact is not modelled. The selected boundary conditions are equivalent to the short-circuit operation of the cell.Interestingly, the simulation suggests that built meshes which had earlier been used for porous electrode simulation could not adequately describe the electron concentration profile for thinner electrodes despite providing a correct ME electrode current for limiting cases. The mesh convergence analysis studies were made to optimize the mesh to reduce computation time and memory size. The electrons in the conduction band were quantitatively determined because transport in the semiconducting photoanode is primarily driven by a thermally activated trapping-untrapping mechanism that can be described by transport equations similar to Fick's laws.The unknown parameters (dye absorption coefficient and recombination rate constant) were adjusted to ensure various light intensities in the simulation correspond to the experiment. An accurate description of the electrons within the semiconductor is critical for explaining the time-dependent behavior of the dye-sensitized photoanode in SECM approach curves. After obtaining agreement with experimental approach curves under steady-state conditions, the same parameters are used to study the current transient obtained under intermittent illumination.

Development of an in situ Mediator Dosing Concept for Scanning Electrochemical Microscopy in Lithium‐Ion Battery Research

AbstractIn scanning electrochemical microscopy (SECM), the addition of a redox active species plays an essential role. Those deliberately added mediators may alter results in SECM studies. In investigations of lithium‐ion battery (LIB) materials, especially of the positive electrode, the oxidation potentials of commonly used mediator substances such as ferrocene are located within the operation potential of the electrode. Thus, they possibly interfere with the regular charge/discharge processes. In situ studies are therefore in need of approaches reducing or eliminating the use of mediators. Within this publication, a novel mediator dosing (MD) concept is introduced. A capillary was closely positioned at the tip of the scanning probe. By gravity flow, stable flow rates of mediator solution of up to 32.4±0.6 μL h−1 were achieved. These low amounts were found to be sufficient to form a ferrocene zone at the probe tip enabling feedback mode SECM measurements with comparable quality to measurements directly in ferrocene solution. Proof of concept experiments were conducted by investigation of a thin‐film electrode with a micro‐structured surface. Furthermore, the MD concept was applied in imaging experiments of a commercially available LIB graphite electrode.

Signatures of Active Galactic Nucleus Feedback Modes: A Green Bean Galaxy with 150 kpc Jet-induced Radio Emission

Jetted active galactic nuclei (AGN) hosting extended photoionized nebulae provide us with a unique view of the timescales associated with AGN activity. Here, we present a new green bean galaxy at z = 0.304458 ± 0.000007 with large-scale jet-induced radio emission. The spectral energy distributions of the radio components show steep spectral indices (α = −0.85 to −0.92 for the extended regions, and α = −1.02 for the faint radio core), and spectral age modeling of the extended radio emission indicates that the lobes are >6 Myr old. It is unclear whether the jet is active, or is a remnant with an off-time of 2–3 Myr. Several detached clouds lie around the host galaxy up to 37.8 kpc away from the nucleus, and their ionization profile indicates a decline (∼2 dex) in the AGN ionizing photon production over the past ∼0.15 Myr. Furthermore, we measure a blueshift for one of the clouds that is spatially coincident with the path of the radio jet. The cloud is likely illuminated by the photoionizing AGN, and potentially underwent an interaction with the relativistic jet. Our multiwavelength analysis suggests that RGB1 was in a phase of jet production prior to the radiatively efficient accretion phase traced by the detached cloud emission. It is unclear whether RGB1 transitioned into a low-excitation radio galaxy or an inactive galaxy over the past ∼0.15 Myr, or whether the extended radio and optical emission trace distinct accretion phases that occurred in succession.

Research on the Cultivation of Primary School Chinese Core Literacy from the Perspective of Information Technology Media

In 2024, Huai Jinpeng, secretary of the Party Group and Minister of the Ministry of Education, pointed out in his speech at the National Education Conference that we should "strengthen the reform and innovation of education and teaching, and constantly explore and practice new teaching methods and means". Nowadays, cultivating primary school students' Chinese core quality has become an important direction of primary school Chinese classroom reform, the core of which lies in cultivating students' individual cognition and application ability of Chinese. Based on this, this paper breaks down the cultivation concept of primary Chinese core quality into individualized learning orientation, teaching orientation of students' subjectivity and feedback mode of multiple evaluation. The paper deeply integrates the use of information technology media with primary school Chinese teaching, and puts forward the cultivation mode of primary school Chinese core quality under the vision of information technology media. This model includes three parts: deep interaction of teaching and research, flipped classroom learning model, multiple evaluation and intelligent data management, in order to help the reform of the primary school Chinese core literacy training model.

Examining teacher’s evaluative language in written, audio and screencast feedback on EFL learners’ writing from the appraisal framework: A linguistic perspective

Technology facilitates teacher corrective feedback on students' writing, but there is a need to examine how written, audio and screencast modes affect teacher's evaluative language of electronic (e-) feedback from linguistic approaches. By using the engagement resources of the appraisal framework within Systemic Functional Linguistics, this study examined the effect of written, audio and screencast modes on the instructor's evaluative language in his e-feedback on writing and the text revisions of 15 pairs of Saudi EFL learners. The linguistic analysis of the e-feedback revealed that the instructor's engagement resources differed across the three e-feedback modes. Specifically, the screencast and audio e-feedback modes were dominated by expanding resources (resources expanding the space for dialogue) as opposed to the prevalence of contracting resources (resources limiting/shutting down the space for dialogue) in the written feedback mode. Moreover, the audio and screencast feedback modes contained more statements and suggestions whereas the written feedback mode was dominated by commands/orders and suggested corrections. The content analysis revealed that the screencast e-feedback mode addressed a higher number of global issues in writing; however, the audio and written e-feedback modes addressed a higher number of local issues in writing. Despite the higher overall rate of successful text revisions resulting from the screencast and audio e-feedback modes, no significant differences were found except in relation to students' global text revisions. The study offers useful pedagogical implications for instructors in effectively responding to students' writing.

Mapping the Imprints of Stellar and Active Galactic Nucleus Feedback in the Circumgalactic Medium with X-Ray Microcalorimeters

The Astro2020 Decadal Survey has identified the mapping of the circumgalactic medium (CGM; the gaseous plasma around galaxies) as a key objective. We explore the prospects for characterizing the CGM in and around nearby galaxy halos with a future large-grasp X-ray microcalorimeter. We create realistic mock observations from hydrodynamical simulations (EAGLE, IllustrisTNG, and Simba) that demonstrate a wide range of potential measurements, which will address the open questions in galaxy formation and evolution. By including all background and foreground components in our mock observations, we show why it is impossible to perform these measurements with current instruments, such as X-ray CCDs, and why only microcalorimeters will allow us to distinguish the faint CGM emission from the bright Milky Way (MW) foreground emission lines. We find that individual halos of MW mass can, on average and depending on star formation rate, be traced out to large radii, around R 500, and for larger galaxies even out to R 200, using prominent emission lines, such as O vii, or O viii. Furthermore, we show that emission-line ratios for individual halos can reveal the radial temperature structure. Substructure measurements show that it will be possible to relate azimuthal variations to the feedback mode of the galaxy. We demonstrate the ability to construct temperature, velocity, and abundance ratio maps from spectral fitting for individual galaxy halos, which reveal rotation features, active galactic nucleus outbursts, and enrichment.

Multiphase Black Hole Feedback and a Bright [C ii] Halo in a LoBAL Quasar at z ∼ 6.6

Although the mass growth of supermassive black holes during the epoch of reionization is expected to play a role in shaping the concurrent growth of their host galaxies, observational evidence of feedback at z ≳ 6 is still sparse. We perform the first multiscale and multiphase characterization of black-hole-driven outflows in the z ∼ 6.6 quasar J0923+0402 and assess how these winds impact the cold gas reservoir. We employ the SimBAL spectral synthesis to fit broad absorption line features and find a powerful ionized outflow on a ≲210 pc scale, with a kinetic power ∼2%–100% of the quasar luminosity. Atacama Large Millimeter/submillimeter Array (ALMA) observations of [C ii] emission allow us to study the morphology and kinematics of the cold gas. We detect high-velocity [C ii] emission, likely associated with a cold neutral outflow at ∼0.5−2 kpc scale in the host galaxy, and a bright extended [C ii] halo with a size of ∼15 kpc. For the first time at such an early epoch, we accurately constrain the outflow energetics in both the ionized and the atomic neutral gas phases. We find such energetics to be consistent with expectations for an efficient feedback mechanism, and both ejective and preventative feedback modes are likely at play. The scales and energetics of the ionized and atomic outflows suggest that they might be associated with different quasar accretion episodes. The results of this work indicate that strong black hole feedback is occurring in quasars at z ≳ 6 and is likely responsible for shaping the properties of the cold gas reservoir up to circumgalactic scales.

Exploring EFL learner engagement with different teacher feedback modes

Despite the growing interest in learners’ feedback engagement in second language writing in recent decades, learners’ multidimensional engagement with teachers’ feedback provided via different modes is an issue yet to be explored. Using the case study approach, this study explored how five Saudi university EFL students engaged affectively, behaviorally, and cognitively with teacher feedback provided via three different modes: oral, audio-recorded, and automatically written feedback. Content and textual analysis of students ‘drafts, reflections on mistakes, semi-structured interviews, and final course reflections revealed that the students’ high, moderate, and low engagement patterns were mediated by the affordances of the modes. Regardless of their preference for certain modes, highly - engaged students show deep engagement cognitively and behaviorally. Further, their cognitive and metacognitive strategies were triggered by the affordances of their preferred mode. Moderately and low engaged students had more complex engagement patterns and there was a nonlinear and inconsistent relationship among the three engagement dimensions. While the students’ cognitive engagement with the mode mediated their affective engagement to a great extent, mismatches persisted. Similarly, the students’ affective engagement with certain modes did not influence their revision uptake, but the aversion to certain modes indirectly led to withdrawal that consequently impacted their behavioral and cognitive engagement. The paper highlights the influence of alignment and misalignment between learners and contextual factors that further exacerbate the inconsistency across the three dimensions. The results suggest that writing teachers should be aware of different modes’ affordances in relation to learners’ needs and preferences to harvest their feedback engagement.

The first high-redshift cavity power measurements of cool-core galaxy clusters with the International LOFAR Telescope

Radio-mode feedback associated with the active galactic nuclei (AGNs) at the cores of galaxy clusters injects a large amount of energy into the intracluster medium (ICM), offsetting radiative losses through X-ray emission. This mechanism prevents the ICM from rapidly cooling down and fueling extreme starburst activity as it accretes onto the central galaxies, and it is therefore a key ingredient in the evolution of galaxy clusters. However, the influence and mode of feedback at high redshifts (z ∼ 1) remains largely unknown. Low-frequency sub-arcsecond-resolution radio observations taken with the International LOFAR Telescope have demonstrated their ability to assist X-ray observations with constraining the energy output from the AGNs (or “cavity power”) in galaxy clusters, thereby enabling research at higher redshifts than before. In this pilot project, we tested this hybrid method on a high-redshift (0.6 < z < 1.3) sample of 13 galaxy clusters for the first time with the aim of verifying the performance of this method at these redshifts and providing the first estimates of the cavity power associated with the central AGN for a sample of distant clusters. We were able to detect clear radio lobes in three out of 13 galaxy clusters at redshifts of 0.7 < z < 0.9, and we used these detections in combination with ICM pressures surrounding the radio lobes obtained from standard profiles to calculate the corresponding cavity powers of the AGNs. Combining our results with the literature, the current data appear to suggest that the average cavity power peaked at a redshift of z ∼ 0.4 and slowly decreases toward higher redshifts. However, we require more and tighter constraints on the cavity volume and a better understanding of our observational systematics to confirm any deviation of the cavity power trend from a constant level.

Label-Free Assessment of Neuron-Specific Enolase via Polydopamine over a Carbon-Nanotube-Based Flexible Immunosensor.

A label-free electrochemical immunosensor was developed for the rapid and sensitive detection of neuron-specific enolase (NSE). The electropolymerization of dopamine in conjunction with highly conductive carbon nanotubes offers a simple and quick platform for the direct anchoring of antibodies without the assistance of any coupling agent as well as a blocking agent. The developed immunosensor exhibited a wider detection range from 120 pM (9 ng mL-1) to 3 nM (200 ng mL-1) for NSE with a high sensitivity of 3.9 μA pM-1 cm-2 in 0.1 M phosphate-buffered saline (PBS) at physiological pH (7.4). Moreover, the short recognition time (15 min) for the antigen enabled the detection to be fast and less invasive. Additionally, the evaluation of a rate constant at various concentrations of NSE via feedback mode of scanning electrochemical microscopy (SECM) explained the profound effect of antigen concentration on the rate of flow of electrons. Therefore, the proposed immunosensor can be a promising tool for the early detection of small cell lung cancer in a very short period of time with consistent accuracy.