84 Background: The degree to which electronic health records enhance the quality of patient care depends on how the system is used to monitor and improve practice. In planning the transition to Epic’s electronic chemotherapy ordering platform, we saw an opportunity to increase evidence-based practice. Methods: Our Chemotherapy Council vetted more than 600 electronic protocols based entirely on published clinical trials and NCCN guidelines; modifications made to these protocols represent a divergence from clinical evidence. We examined the number of times the chemotherapy section of a protocol was modified before the first cycle to avoid counting dose modifications made for toxicities. To get the rate for the cancer center we calculated the # of discrete times all protocols were used (denominator) and the number of times all protocols were modified (numerator). We subtracted the ratio from 1 to reflect the proportion of protocols that were not modified. This ratio serves as a new quality metric – the Rate of Evidence-Based Adherence (REBA). REBA institution= 1 - Total # of modifications prior to first cycle for each protocol. The total # of uses of all protocols. Additionally, REBA can be used to examine disease group rates (REBA group), individual provider rates (REBA provider) and rates for individual protocols (REBA protocol). Institutions that have implemented evidence-based clinical pathways have strived for 80% (.80) adherence. We set this as our REBA benchmark. Results: The REBA institution was .86, higher than our pre-defined goal (p<0.001). There was wide variation in the REBA group (range 0.50-0.95). The REBA protocol identified two protocols (rates of .33 and .42 respectively) that were dose reduced the majority of the time. In the example of our Breast Group, the REBA provider, ranged from (.78 to .97) reflecting differing practice among 4 physicians. Conclusions: The REBA can identify faculty and disease groups who underutilize clinical evidence, facilitating feedback for quality improvement. The REBA protocol is a useful tool to identify specific chemotherapy templates that may need modification. The REBA is a powerful electronic tool, which can be utilized to monitor and enhance the rate of evidence-based practice in oncology.