Complex systems operations, such as Nuclear Power Plants (NPPs), generally require professional operating teams. Factors associated with teamwork, such as inappropriate communication and coordination, are important contributing factors to accidents and unsafe behavior. The impact of crew interactions on team effectiveness and, consequently, on the entire system, has yet to be fully and quantitatively explored in high-risk environments such as NPPs. Since a team is an interactive social system, team-specific issues must be studied and evaluated from a “team perspective”—based on team dynamics and processes. This paper is a part of a two-papers series that presents a simulation-based Team Model for NPP control room operations. Part 1 describes the theoretical fundaments of the model and details its elements. The current paper, Part 2, describes the simulation aspects and a full application of the method to an NPP four-steam generator feedwater system pipe break. It presents how to set up the simulation elements, such as hardware and humans within a team, using MATLAB Simulink. The method is demonstrated through a case study of an NPP four-steam generator feed water system pipe break. The results are discussed and assessed against theoretical and experimental findings.