Sesamum indicum (sesame) is a small seed legume, which is of nutritional and medicinal value to livestock. Sesame is a legume with positive attributes that include drought tolerance (owing to its extensive rooting system), low input demand for growth, and reduction of soil nematodes (in crop rotation systems). Attention in research has been shifted towards usage of sesame as human food to exploitation as livestock feed because of its high levels in crude protein (CP), minerals, amino acids, and polyunsaturated fatty acids (PUFAs). However, it is underutilized as a livestock feed resource in Southern Africa. In recent years, there has been increasing interest to cultivate the crop in Southern African countries through non-governmental organizations (NGOs) initiatives. The focus of such initiatives has been mainly production without value addition of the seed. At present in Southern Africa, widespread adoption of feeding strategies based on sesame has been restricted mainly due to lack of knowledge on production, marketing and value addition, availability of the seed, and technology adoption. Technology adoption is often limited specifically when oil extraction is considered, where by-products such as the meal are useful in animal production. This paper reviews the potential use of sesame to improve growth rates, feed intake, carcass qualities, meat quality, milk quality, milk yield, and blood metabolite levels of small ruminants. Production potential, economic feasibility, and strategies of using sesame in small-ruminant feeding programs are also outlined.