Ni3Al-based superalloy IC10 is widely used in high temperature components of aero-engines because of its superior mechanical properties. In this paper, the creep feed grinding properties of IC10 were investigated experimentally. The effects of grinding parameters on the grinding forces and temperature were examined. Moreover, the influences of surface roughness and hardening on the high-cycle fatigue life of IC10 specimens were studied. To control the creep feed grinding parameters and enhance the fatigue life of IC10 components, the experimental results were summarized to offer a useful reference point. It is concluded that, the grinding depth is the most important factor which influencing the grinding forces and temperature; the surface roughness is the main and unfavorable factor on the fatigue life of IC10, while the surface hardening has a positive influence on the fatigue life; to obtain a better surface quality and improve the fatigue life of IC 10, the recommended grinding parameter domain involves wheel speed ∈ [15, 20] m/s, feed rate ∈ [150, 200] mm/min, and grinding depth ∈ [0.4, 0.5] mm.