This research aims to determine the brittleness index (BI) and engineering properties of limestone specimens. In addition, this study evaluates the effect of moisture on the developed models to predict the BI and shear wave velocity (Vs), based on the point load index (Is50), dry and saturated tensile strength (Ts-d and Ts-s), and porosity. Gaussian process regression (GPR), multilayer feed-forward neural network (MFFNN), and multiple linear regression (MLR) predictive models were utilized. Microscopic examination of the limestone specimens revealed that calcite is the predominant mineral. It was observed that samples with higher calcite content exhibited greater brittleness and strength properties while having lower porosity. The results obtained from the MLR analysis demonstrated that it is possible to accurately forecast the brittleness index (BI), as well as the dry and saturated shear wave velocities (Vs-d and Vs-s) at the specific sites under investigation. The moisture effect on developed models showed that Vs prediction in dry conditions (Vs-d) was less accurate compared to the saturated conditions (Vs-s). Conversely, the relationships developed for estimating the BI in dry conditions exhibited higher accuracy. The analysis of all model assumptions using MLR indicated that the models could be reliably utilized. However, the MFFNN and GPR methods were found to be more conservative in estimating these properties. Moreover, the study identified the best transfer function and training algorithm for predicting Vs and BI. The evaluation metrics, such as R2 and RMSE revealed that GPR demonstrated higher precision compared to MFFNN and MLR.