With the increasing trend of greenhouse gases in the atmosphere, by 2052 the temperature is expected to rise by 1.5 °C from the Pre-industrial Period, affecting future extreme rainfall events. This necessitates quantifying extreme hydrologic events to plan and design hydrologic and hydraulic structures using rainfall Intensity-Duration-Frequency (IDF) curves to adapt to future climate scenarios. This study developed future projected IDF curves for the Southeast United States using disaggregated sub-hourly (15-, 30-, and 45-min) monthly maximum rainfall from 2030 to 2059 using five climate models under the Representative Concentration Pathway 8.5 scenario. A computationally efficient feed-forward back-propagation Artificial Neural Network (ANN)-based approach was found to be significantly superior for disaggregating rainfall to a stochastic model with an average Nash–Sutcliffe efficiency (NSE) ranging from 0.67 to 0.84. The study found that there is an increasing rate of future projected annual maximum rainfall intensities in the range of 7% to 36% with reference to the historical period. The spatial variation in future projected extreme rainfall depths showed that the Gulf-Atlantic coast and the Appalachian Mountains are expected to receive more extreme rainfalls.