The processes of digital transformation, which are becoming increasingly important in the global economy, are now increasingly active in such spheres as public administration, which are not directly related to production activities. During the first decade of the XXI century, the digitalization of the Russian public administration system primarily consist-ed in the formation of a number of federal information systems, but by the end of the second decade, the regional level began to show increasing dynamics of implementation of digital tools. In the framework of the regional digital transfor-mation, the main difference from the federal one is the presence at the grassroots level of a number of autonomous mu-nicipal organizations that are not subordinate to the regional center and in some cases have their own vision of this pro-cess. Under such conditions, municipal-regional interaction in the field of digital tools of public administration acquires great importance. However, this process is characterized by a low level of formalization and can look like a set of unrelat-ed functional processes, which leads to the lack of comprehensive research in this area. At the same time, the process of regional-municipal interaction, according to the hypothesis of this study, is a complex of interrelated elements based on economic factors, the violation in the practical implementation of each of which contributes to the formation of prerequi-sites for the inefficient use of digital tools. Thus, the purpose of this study is to analyze the structure and composition of the regional-municipal interaction in the framework of the use of digital tools of public administration. On the basis of the goal, the study defined a number of tasks, including the definition of the essence of this interaction, identifying its struc-ture and composition. The study was based on the normative legal acts of public authorities, official digital publications of state and municipal organizations, scientific publications on the digitalization of public administration. According to the results of the study, the basic elements of interaction, their interrelations, and the associated potential risks of disruption of the effective use of digital tools were identified.