Features Of Granulomatous Inflammation Research Articles

A rare case of malakoplakia of the urinary bladder

Malakoplakia (from Greek Malako “soft” + Plako “plaque”) is a rare inflammatory condition that presents as a papule, plaque, or ulceration that usually affects the genitourinary tract. The most frequently affected organ is the urinary bladder. This condition has features of granulomatous inflammation. The pathogenesis of the disease is not completely understood. It is often misdiagnosed as malignancy. In this case report, we present a case of urinary bladder malakoplakia which presented with obstructive uropathy and acute kidney injury (AKI).

Features of granulomatous inflammation in helminthiasis, mycoses and human protozoal diseases in forensic medical practice

Is to draw the attention of forensic experts and histologists to the problem of infectious diseases occurring with the formation of granulomas. Was reviewed the general patterns of granulomatous diseases, as well as the peculiarities of pathomorphosis in helminthiasis (schistosomiasis, paragonimiasis, onchocerciasis, dirofilariasis, ascariasis, cysticercosis), mycoses (cryptococcosis, chromomycosis, coccidioidosis) and protozoal diseases, toxosomes. The article includes photomicrographs from the authors' personal archive, including those collected during their work in African countries Text is based on scientific data from articles, monographs, educational literature, personal experience and cases of forensic medical practice.

Медико-социальные факторы, эпидемиологические и клинико-морфологические особенности ко-инфекции ВИЧ/туберкулёз на примере Волгоградской области

The purpose of this paper is to review the epidemiological, socio-medical, clinical and morphological aspects of the two infections of HIV and tuberculosis to clarify the characteristics of patients and to identify pathologic features of granulomatous inflammation in co-infection with HIV / TB at the level of light microscopy. The material of the research was medical records of patients, who died and persons consisting on the dispensary with HIV infection, tuberculosis and co-infection with HIV / tuberculosis. Morphological part of the research was carried out with the study of autopsy material of death patients with HIV infection and tuberculosis in the Volgograd region. The increase in the number of HIV-infected and high rates of TB in the Volgograd region affect on the epidemic process in co-infecciosa due vulnerable groups and socio against non-adaptable layers of population, which in most cases neglected complete therapy, ARVs and anti-TB therapy and are drug users, on the background of which there is a progression of human immunodeficiency virus and tuberculosis. Morphological research of deceased persons from the co-infection HIV/TB can detect the violation of structure of classical tuberculosis granuloma. In tubercular granuloma except tricks caseous necrosis, surrounded by few epitelialna cells, isolated multinucleated giant cells Pirogov-Langhans,a small number of small lymphocytes were identified, and the appearance on the periphery of neutrophilic leukocytes and severe exudative reaction was revealed.

Rinosporidiose da conjuntiva: relato de caso

Rhinosporidiosis is a rare fungal infection, specially when it involves the eye. Its etiologic agent is Rhinosporidium seeberi, which produces elevated and polypoid lesions, with features of granulomatous inflammation, rich in parasites. The authors report a case with tarsal conjunctival impairment in a 22-year-old patient. This is the first case of the ocular disease in the state of Espirito Santo. The clinical features, etiology, pathogenesis, diagnosis and therapy are discussed.

Granulomatous inflammation in bladder wash specimens after intravesical bacillus Calmette-Guerin therapy for transitional cell carcinoma of the bladder.

The authors retrospectively reviewed a series of bladder wash cytologic specimens and concurrently available bladder biopsy samples to evaluate granulomatous inflammation in patients receiving intravesical bacillus Calmette-Guerin (BCG) immunotherapy for transitional cell carcinoma of the bladder. Comparisons were made during the 2-month period following six weekly BCG instillations in 25 patients and during the 1-year period following the last dose of BCG in 23 patients. At some point during the 2-month follow-up period, cytologic specimens contained free histiocytes in 64%, histiocyte aggregates (resembling fragments of granulomas) in 76%, and multinucleated histiocytic giant cells in 56% of patients. Similarly, concurrent biopsy samples contained granulomas in 78% and multinucleated giant cells in 56% of patients. During the 1-year period following the last dose of BCG, inflammatory changes peaked within the first 3 months and gradually resolved at 9-12 months. In none of these instances were the cytologic features of granulomatous inflammation misinterpreted as malignant. It was concluded that the cytologic findings after intravesical BCG are more specific than previously realized and closely parallel the histologic changes seen in corresponding bladder biopsy specimens.