Медико-социальные факторы, эпидемиологические и клинико-морфологические особенности ко-инфекции ВИЧ/туберкулёз на примере Волгоградской области

Abstract

The purpose of this paper is to review the epidemiological, socio-medical, clinical and morphological aspects of the two infections of HIV and tuberculosis to clarify the characteristics of patients and to identify pathologic features of granulomatous inflammation in co-infection with HIV / TB at the level of light microscopy. The material of the research was medical records of patients, who died and persons consisting on the dispensary with HIV infection, tuberculosis and co-infection with HIV / tuberculosis. Morphological part of the research was carried out with the study of autopsy material of death patients with HIV infection and tuberculosis in the Volgograd region. The increase in the number of HIV-infected and high rates of TB in the Volgograd region affect on the epidemic process in co-infecciosa due vulnerable groups and socio against non-adaptable layers of population, which in most cases neglected complete therapy, ARVs and anti-TB therapy and are drug users, on the background of which there is a progression of human immunodeficiency virus and tuberculosis. Morphological research of deceased persons from the co-infection HIV/TB can detect the violation of structure of classical tuberculosis granuloma. In tubercular granuloma except tricks caseous necrosis, surrounded by few epitelialna cells, isolated multinucleated giant cells Pirogov-Langhans,a small number of small lymphocytes were identified, and the appearance on the periphery of neutrophilic leukocytes and severe exudative reaction was revealed.