Abstract For safety, reliability, and uninterrupted output of gas turbines, aviation engines, power-generating equipment, pumps, gears, compressors etc., rotor mass imbalance must be detected and diagnosed to avoid catastrophic failure. Industry 4.0 relies on predictive digital maintenance and deep learning-based convolutional neural network (CNN), which predicts defects but fails if the operating conditions change. Research studies in various fields indicate that the domain shift issue occurs due to source and target samples being from different domains, which reduces prediction capability. Moreover, research studies are scarce in examining prediction capability under varying operating speeds for rotor mass imbalance. Hence, this research proposes the adversarial discriminative domain adaptation (ADDA) technique which predicts machine failures under various operational conditions. The efficacy of ADDA has been explored by introducing 1D-CNN as a source and a target encoder inside ADDA's architecture to take advantage of CNN's feature extraction capability. Further, this research effectively tackles CNN's inherent issues of overfitting and hyperparameters value selection. Furthermore, The real-world scenario has more healthy samples than fault condition samples, causing a multiclass imbalance in sample data, which affects the classification decision boundary and causes biased prediction. Hence, the proposed methodology first addresses the class imbalance through synthetic minority oversampling (SMOTE), then genetic algorithm optimizes 1D-CNN's hyperparameters, and the effective dropout layer positioning solves the overfitting. Finally, the deep learning-based SMOTE_ADDA_GO-1D-CNN decreases domain discrepancy with adversarial discriminative domain adaptation. The proposed methodology's efficacy has been explored through F1-Score, which is used as multiclass evaluation metrics, and it has been benchmarked against standard machine learning and deep learning algorithms. The test results of the proposed methodology surpassed all of them with maximum prediction accuracy. Thus, this study contributes to rotor mass imbalance detection and diagnosis for multiclass imbalanced data under varying operational conditions by successfully overcoming potential challenges during fault prediction.