Robust localization and mapping are crucial for autonomous systems, but traditional handcrafted feature-based visual SLAM often struggles in challenging, textureless environments. Additionally, monocular SLAM lacks scale-aware depth perception, making accurate scene scale estimation difficult. To address these issues, we propose D3L-SLAM, a novel monocular SLAM system that integrates deep keypoints, deep depth estimates, deep pose priors, and a line detector. By leveraging deep keypoints, which are more resilient to lighting variations, our system improves the robustness of visual SLAM. We further enhance perception in low-texture areas by incorporating line features in the front-end and mitigate scale degradation with learned depth estimates. Additionally, point-line feature constraints optimize pose estimation and mapping through a tightly coupled point-line bundle adjustment (BA). The learned pose estimates refine the feature matching process during tracking, leading to more accurate localization and mapping. Experimental results on public and self-collected datasets show that D3L-SLAM significantly outperforms both traditional and learning-based visual SLAM methods in localization accuracy.