Feasibility Study Research Articles

A feasibility study on the use of an intraoral optical coherence tomography system for scanning the subgingival finish line for the fabrication of zirconia crowns: An evaluation of the marginal and internal fit

ObjectivesThis study aimed to evaluate the marginal and internal fit of zirconia crowns were fabricated using scan data from an intraoral optical coherence tomography (OCT) scanner and an intraoral scanner (IOS) for scanning the subgingival finish line. MethodsAn extracted maxillary left central incisor was prepared for a zirconia crown. The prepared tooth was placed in artificial gingiva, created using silicone with a refractive index similar to that of the tooth, ensuring a subgingival depth of 0.50 to 0.70 mm from the labial finish line. Scanning data were obtained from four types of models as follows. (1) CAD reference model (CRM) excluding the gingiva and scanned using a laboratory scanner. (2) IOS group excluding the gingiva (IOS only, IOSO group). (3) IOS group with scanned attached artificial (IOS with gingiva, IOSG group). (4) OCT post-processed data of the subgingival finish line and IOSG data (OCT group). Zirconia crowns were fabricated based on these data, and their marginal and internal fit were evaluated using the silicone replica technique. Statistical analyses were conducted using one-way and two-way ANOVA (α = 0.05). ResultsThe OCT group exhibited a significantly smaller marginal gap than the IOSG group (P < 0.05). The marginal fit of the OCT group did not significantly differ from that of the CRM group (P > 0.05). The IOSG group exhibited a significantly larger chamfer gap, while both the IOSG and OCT groups had significantly larger axial gaps. Furthermore, the OCT group showed a significantly larger incisal gap (P < 0.05). ConclusionsAn intraoral OCT system can enhance the fabrication accuracy of zirconia crowns by achieving superior marginal fit for crowns with subgingival finish lines. Clinical significanceThe use of an IOS for subgingival finish lines without gingival displacement cords may result in a suboptimal marginal fit. However, integrating OCT technology can effectively address this issue, leading to improved clinical outcomes.

Treated wastewater reuse for irrigation: A feasibility study in Portugal

In an increasing water scarcity and climate-vulnerable global context, treated wastewater represents a vital alternative water source, thereby enhancing resource sustainability. Despite its potential, only roughly 2.5 % of the treated wastewater is reused in the European Union, with Portugal's reuse rate being only 1.2 % in 2022. Considering this framework, this study evaluates the feasibility of increasing wastewater reuse in Portugal by focusing on the Tagus River and Ribeiras do Oeste Basins. The regional assessment identified eight key wastewater treatment plants (WWTP) with significant potential for irrigation reuse in the agriculture and tourism sectors. Analysing costs, quality requirements, and technological options, this study considered five treatment lines, incorporating filtration and disinfection methods. The findings indicate that reclaimed water costs may range from 0.02€/m3 to 0.83€/m3, being competitive with other water sources and significantly lower than desalination processes (up to 1.66€/m3). Distribution investments and energy consumption are primary cost drivers, suggesting a relocation of WWTP closer to end-users as a cost-saving strategy. The proposed reuse projects could quadruple regional reuse rates and double the national rate, mitigating water needs for over 2000 ha of agricultural land and golf courses. This study underscores the importance of treated wastewater reuse in addressing water scarcity, advocating for WWTP decentralisation, strategic investments and policy interventions to achieve cost-effective goals. The methodologies and insights presented offer valuable guidance for other regions facing similar challenges, promoting a paradigm shift towards circular water resource management.

08O To manually or mechanically cough: that is the question! Cough augmentation in children with neuromuscular disorders: a feasibility study

08O To manually or mechanically cough: that is the question! Cough augmentation in children with neuromuscular disorders: a feasibility study

Feasibility study on discrimination of Polygonatum kingianum origins by NIR and MIR spectra data.

Most existing studies have focused on identifying the origin of species with protected geographical indications while neglecting to determine the proximate geographical origin of different species. In this study, we investigated the feasibility of using near- and mid-infrared spectroscopy to identify the origin of 156 Polygonatum kingianum samples from six regions in Yunnan, China. In this work, spectral images of different modes reveal more information about the P. kingianum. Comparing the performance of traditional machine learning models according to single spectrum and data fusion, the middle-level data fusion-principal component model has the best performance, and its sensitivity, specificity, and accuracy are all 1, and the model has the least number of variables. The residual convolutional neural network (ResNet) model constructed in the 1050-850cm-1 band confirms that fewer variables are beneficial in improving the accuracy of the model. In conclusion, this study verifies the feasibility of the proposed strategy and establishes a practical model to determine the source of P. kingianum.

Feasibility test of WORK-ON: a vocational rehabilitation intervention for people with chronic inflammatory arthritis

BackgroundPeople with chronic inflammatory arthritis (IA) often have a reduced work ability. Consequently, they are at high risk of losing their jobs and being permanently excluded from the labor market. Therefore, we developed a new context-specific vocational rehabilitation intervention for people with IA based on the Medical Research Council’s framework for complex interventions. This intervention is called “WORK-ON” and consists of: (1) Initial assessment and goal setting by an occupational therapist experienced in rheumatology rehabilitation; (2) coordinated support from the same occupational therapist, including assistance in navigating the primary and secondary healthcare and social care systems; (3) group sessions for peer support; and (4) individually tailored consultations with physiotherapists, nurses, and/or social workers. This study investigates the feasibility of WORK-ON.MethodsA 6-month single-arm feasibility study with a pre-test post-test design was conducted to evaluate recruitment, intervention fidelity and delivery, data collection, and possible outcome measures. Work ability was the primary outcome, and sick leave, quality of life, fatigue, pain, physical activity, sleep, and well-being were the secondary outcomes evaluated.ResultsIn total, 19 participants (17 women and 2 men) with a median age of 55 years (range, 34–64) participated and completed WORK-ON. Of these, 17 participants completed patient-reported outcomes at baseline and follow-up, and the results indicated a tendency to improvement in work ability, quality of life, level of physical activity, decrease in pain, and increase in days of sick leave during the 6-month intervention period. The rehabilitation clinicians spent an average of 15.3 h per participant, and the participants spent an average of 13.5 h in the intervention.ConclusionsWORK-ON is considered feasible and has the potential to increase work ability among people with IA who are concerned about their future ability to keep working. Though, an adjustment of the intervention is needed before testing in a randomized controlled trial.

Impact of motion management strategies on abdominal organ at risk delineation for magnetic resonance-guided radiotherapy

Background and purposeThe impact of respiratory motion management strategies for abdominal radiotherapy, such as abdominal compression (AC) and breath hold (BH), on abdominal organ at risk (OAR) delineation on magnetic resonance imaging (MRI) is unknown. This feasibility study compared the inter- and intra- observer delineation variation on MRI acquired with AC, BH for three critical abdominal OAR. Materials and methods3D T2-weighted (W) MRI in free-breathing (FB) and with AC, and T1W 3D mDixon exhale BH were acquired. Four observers blinded to motion management strategy used, delineated stomach, liver, and duodenum on all MRI. One case per strategy was repeated over 6 weeks later to quantify intra-observer variation. Simultaneous truth and performance level estimation (STAPLE) contours for each OAR were generated, median and IQR mean distance to agreement (mDTA) and maximum Hausdorff distance (HD) between observer and STAPLE contours were calculated. Observers scored organ visibility on each MRI using a four-point Likert scale. ResultsA total of 27 scans including repeats were delineated. Pooled mDTA for all OAR was 1.3 mm (0.5 mm), 1.4 mm (1.0 mm), and 1.3 mm (0.5 mm) for AC, BH and FB, respectively. Intra-observer mDTA was highest for all organs in FB with 10.8 mm, 1.8 mm and 2.7 mm for duodenum, liver and stomach, respectively. The pooled mean perceptual quality score value was highest for AC across organs. ConclusionsNo motion management strategy demonstrated superior similarity across OAR, emphasizing the need for personalised approaches based on individual clinical and patient factors.

Feasibility study of utilizing Autoclaved Aerated Concrete (AAC) waste for the production of cold bonded lightweight artificial aggregate using High Volume Fly Ash (HVFA) binders

Autoclaved Aerated Concrete (AAC) is a popular construction material used for partitions and insulation in buildings. At the end of its service life, AAC (Autoclaved Aerated Concrete) will be demolished and subsequently disposed of in landfills, thereby creating depository problem. Therefore, the study of reutilization and recycling of AAC waste is imperative. Artificial aggregate production can be an alternative to the reutilization of AAC waste. This paper assesses the feasibility of using Autoclaved Aerated Concrete Powder (AACP) waste as a raw material for the production of artificial aggregate and investigate its physico-mechanical properties. The investigation incorporates the comparison of cement-based binder with high-volume fly ash (HVFA) binder with different replacement levels of cement. The study uses image analysis based on photographic, optical microscopic, and scanning electron microscopy (SEM) images, to describe the porosity of the aggregate. The results show that the AACP aggregates with both cement and HVFA binders meets the current industry requirement for density and cylinder crushing strength as lightweight artificial aggregate. The appropriate binder content lies between 30-40%. The best cement to fly ash ratio in HVFA binder is determined to be of 1:1 with 50% replacement of cement with fly ash. Image analysis showed that the porosity largely affected the properties of the AACP aggregate such as density and water absorption. However, further investigation into the reducing high-water absorption of AACP aggregates is necessary to improve their overall quality.

Shape-sensing Robotic-assisted Bronchoscopy (SS-RAB) in Sampling Peripheral Pulmonary Nodules: A Prospective, Multicenter Clinical Feasibility Study in China.

The ION system is a shape-sensing robotic-assisted bronchoscopy (SS-RAB) platform developed to biopsy peripheral pulmonary nodules (PPNs). There is a lack of data describing the use of this system in the Chinese population. The study aimed to assess the feasibility and safety of using SS-RAB to diagnose PPNs across multiple centers within China. This prospective, multicenter study used SS-RAB in consecutive patients with solid or sub-solid PPNs 8 to 30mm in largest diameter. Primary endpoints were diagnostic yield and the rates of procedure- or device-related complications. Radial endobronchial ultrasound (rEBUS) was to confirm lesion localization, followed by sampling, using the Flexision biopsy needle, biopsy forceps, and cytology brush. Subjects with nonmalignant index biopsy results were followed up to 6 months. A total of 90 PPNs were biopsied from 90 subjects across 3 centers using SS-RAB. The median nodule size was 19.4mm (IQR: 19.3, 24.6) in the largest dimension. In all (100%) cases, the catheter successfully reached the target nodule with tissue samples obtained. The diagnostic yield was 87.8% with a sensitivity for malignancy of 87.7% (71/81). In a univariate analysis, nodule lobar location, presence of bronchus sign, and rEBUS view were associated with a diagnostic sample, but only rEBUS view showed an association in a multivariate analysis. The overall pneumothorax rate was 1.1% without pneumothorax requiring intervention, and there was no periprocedural bleeding. As an emerging technology in the Chinese population, SS-RAB can safely biopsy PPNs with strong diagnostic performance.

Improving resilience and mental well-being among refugees residing at asylum centers in the Netherlands: A Pre-Post Feasibility Study

BackgroundFew studies have explored the effects of mental health and psychosocial support programs among refugees residing at asylum centers. The aim of this study was to assess the feasibility of a positive psychology intervention called BAMBOO among refugees temporarily residing at asylum centers in the Netherlands. MethodData was collected at 35 asylum centers from 243 participants who completed five weekly two-hour sessions. Pre- and post-changes in resilience, happiness, and positive and negative affect were assessed using a one-group pretest–posttest design. Also, program fidelity, participant satisfaction, and program activity suitability were evaluated. ResultsCompleter and intention-to-treat analyses revealed a significant medium increase in resilience, a large increase in happiness, a small increase in positive affect, and a medium decrease in negative affect. Reliable change indices showed a positive change in 24% of the participants on resilience and 13% on positive and negative affect, respectively. Participant retention was 80%. Moreover, participant satisfaction was high. Also, a substantial proportion of participants evaluated reading and writing-based activities as less suitable in comparison to activities based on verbal and creative expression, physical movement, and meditation/prayer. ConclusionsFindings showed significant increases in scores from pre- to post-assessment on resilience, happiness, and positive affect and a decrease in negative affect. Since the study design limits the ability to attribute causation, future controlled studies should be conducted to stablish stronger evidence regarding the program's effects. Additionally, the program could benefit from further adaptation to enhance its cultural sensitivity. Trial registration number: ISRCTN18019972

Determination of Hydrogen Fuel Production from GIS-Based Selected Ponds Using Hybrid Renewable Energy Systems in Kayseri

This study offers the feasibility study of large-scale hydrogen production to establish environmentally friendly hybrid energy facilities based on wind and solar energy resources in the vicinity of lakes and rivers within the Kayseri region of Türkiye. The ultimate objective is to enable hydrogen production from lakes and rivers and identify optimal locations for the installation of hydrogen fuel stations. The precise selection of locations for the designated province is based on geographical, environmental, and infrastructural considerations by utilizing GIS technology which allows spatial analysis and superimposition of various layers. The methodology also involves the utilization of the HOMER software to facilitate the integration of wind and solar power, along with hydrogen production, providing a platform for environmentally friendly energy system design and optimization. A comprehensive evaluation has been conducted for the sizing and placement of renewable energy systems based on microgrid analysis, the design of hydrogen production facilities, and the establishment of hydrogen refuelling infrastructure. The study also incorporates a financial analysis to assess the economic viability of the project over its lifecycle. Among the five water sources considered, the highest annual hydrogen production is 830 tons in Zamantı River, while Kızılırmak River has the lowest value according to LCOE and LCOH values, 0.030 $/kWh and 3.85 $/kgH2, respectively.

Perancangan Usaha dan Kelayakan Pembukaan Usaha Kinar Mete di Kota Surabaya

Kinar Mete is a business in the food sector, especially selling cashew nuts, which has been established in 2008 with its production center in Wonogiri. The increasing public interest and consumption of nuts has made the owner of Kinar Mete see the opportunity to expand his business to the city of Surabaya. The feasibility analysis method is used to assess the feasibility of business expansion which includes market, technical, financial aspects as well as sensitivity and risk analysis. The market aspect study obtained from the results of distributing questionnaires to the people of Surabaya City shows that the potential market is 85.33%, the available market is 74%, and the target market is 0.07%. The technical aspect study shows that the business building covers an area of 260 m2 with a workforce of 4 people with working hours Monday-Friday 07.30-16.30 WIB. Financially, the project costs required are IDR 472,955,940. The results of the feasibility study show an NPV of IDR 326,737,829, an IRR of 27.89%, and a PBP of 4.13 years, which shows that the business is worth establishing. Sensitivity analysis shows that business feasibility is sensitive to an increase in raw material costs of 22.38%, labor costs of 57.68%, a decrease in demand of 11.74%, and selling prices of 8.90%. Risk analysis shows that the risk presentation that can occur is 6.35% so that the MARR with a risk of 16.35% results in an NPV value of IDR 180,581,654, an IRR of 27.89%, and a PBP of 4.37 years, which indicates the business remains viable.

Patient engagement in a community-partnered hybrid health-related social needs navigation intervention for adolescents and young adults with cancer (AYA-NAV).

173 Background: Adolescent and young adult (AYAs) cancer survivors experience high rates of financial toxicity (FT), which is associated with poorer health outcomes. FT may disproportionately affect AYAs with unmet health-related social needs (HRSN), such as food or housing insecurity. Needs navigation may be an effective intervention to reduce financial distress, however, engagement has been a challenge in prior adult-directed interventions. We hypothesize that a hybrid navigation delivery model with community organization support and digital delivery will reduce financial distress and improve health outcomes. In a pilot study of AYA-NAV, an AYA-directed needs navigation intervention, we report patient engagement among participants. Methods: Eligible AYAs were 15-39 years old, Spanish- or English-speaking, receiving curative-intent treatment for cancer, and screened positive for FT (Comprehensive Score of Financial Toxicity &lt; 22) or unmet HRSN (food, housing, transportation, or utilities insecurity). Participants were referred for a consultation with the Patient Advocate Foundation (PAF), a national organization that provides case management and navigation support for people facing life limiting illness. At month 1, participants were referred to findhelp.org, a digital platform of comprehensive resources to facilitate resolution of unmet HRSN. Monthly check-ins were conducted by the study team to assess acceptability, intervention fidelity, and provide additional navigation support. We plan to enroll 30 participants on this study. Results: Of 19 AYAs that completed screening to date, 13 met criteria for FT or unmet HRSN; 13 (100%) agreed to AYA-NAV participation. To date, of 46 check-ins initiated by the study team, 33 (72%) were completed. All AYAs connected with the study team at least once during the 6-month duration of the study by text, phone, and/or in-clinic. Ten out of 13 (77%) participants reported that they spoke with a PAF case manager, and 7 (70%) of those said it was helpful. If the patient was unable to connect with PAF, more than half (55%) requested to be reconnected during a monthly check-in. Eight of the 13 (62%) participants visited findhelp.org; 6 (75%) of those found the digital platform to be helpful. Most patients referenced the high usability of findhelp.org, and 55% stated they connected to community resources via findhelp.org. Patients qualitatively reported challenges to intervention participation including medical complications, scheduling conflicts, and work commitments. Conclusions: Preliminary data demonstrate high patient engagement and intervention fidelity during a pilot feasibility study of AYA-NAV. Flexible modes for data collection and intervention delivery are important to inclusion of and retention of AYAs in hybrid navigation delivery models. Clinical trial information: NCT06072833 .

Exploring the Safewards Programme to Reduce Restrictive Practices in Residential Aged Care: Protocol for a Pilot and Feasibility Study.

Restrictive practice use in residential aged care homes internationally is unacceptably high. Although policies and legislation mandate the reduction or elimination of restrictive practices, there remains a gap in knowledge regarding strategies that have been effective in achieving a sustained reduction in restraint use. There is an urgent need to identify effective and feasible interventions that aged care staff can implement in everyday practice to reduce restraint use. Safewards is an evidence-based programme that has demonstrated effectiveness in reducing conflict and restrictive practice use in inpatient psychiatric settings and has the potential to address the issue of restraint use in aged care homes. This study aims to evaluate the feasibility of Safewards in reducing restrictive practices in residential aged care homes. This pilot and feasibility study will adopt a mixed methods process and outcomes evaluation. Safewards will be implemented in two Australian residential aged care homes. The Reach, Effectiveness, Adoption, Implementation and Maintenance framework will be used to evaluate implementation outcomes. Additionally, the Consolidated Framework for Implementation Research will be used to guide qualitative data collection (including semi-structured interviews with residents/family members, aged care leaders and staff) and explain the facilitators and barriers to effective implementation. This study will provide pilot evidence on the feasibility of the Safewards programme in residential aged care homes. Understanding the processes and adaptations for implementing and evaluating Safewards in residential aged care will inform a future trial in aged care to assess its effectiveness. More broadly, the findings will support the implementation of an international aged care policy of reducing restrictive practices in residential aged care. A person with lived experience of caring for someone with dementia is employed as a Safewards facilitator and is a member of the steering committee. Residents and family members will be invited to participate in the project steering committee and provide feedback on their experience of Safewards. ACTRN12624000044527.

Nd Isotopic Equilibration During Channelized Melt Transport Through the Lithosphere: A Feasibility Study Using Idealized Numerical Models

AbstractThis study is motivated by the observed variability in trace element isotopic and chemical compositions of primitive (Si52 wt %) basalts in southwest North America (SWNA) during the Cenozoic transition from subduction to extension. Specifically, we focus on processes that may explain the enigmatic observation that in some localities, basalts with low Ta/Th, consistent with parental melts in a subduction setting, have signatures consistent with continental lithospheric mantle (CLM). In locations with the oldest CLM (Proterozoic and Archean), Cenozoic basalts with low Ta/Th have well below zero. We model channelized magma transport through the CLM using simple 1D transport models to explore the extent to which diffusive and reactive mass exchange can modify Nd isotopic compositions via open system melt‐wallrock interactions. For geologically reasonable channel spacings and volume fractions, we quantify the reactive assimilation rates required for incoming melt with a different than the wall‐rock to undergo a substantial isotopic shift during 10 km channelized melt transport. In the presence of grain boundaries, enhanced diffusion between melt‐rich channels and melt‐poor surrounding rock contributes to isotopic equilibration, however this effect is not enough to explain observations; our models suggest a significant contribution from reactive assimilation of wall‐rock. Additionally our models support the idea that the observed covariability in Ta/Th and in Cenozoic basalts cannot be attributed to transport alone and must also reflect the transition from subduction‐related to extension‐related parental melts in SWNA.

Feasibility of LoRa‐based Infrastructure‐to‐Vehicle (I2V) communication for road weather information systems

SummaryA road‐weather information system (RWIS) is an attractive application in the context of intelligent transportation systems (ITSs), which is used where climatic conditions and meteorological events worsen traffic safety. The primary goal is to significantly reduce potential accidents by sending early warning messages to prompt immediate action. For this purpose, road weather information stations are placed at critical points on the highways. In addition to responsible transportation agencies, enabling direct warning message transfer from roadside infrastructure to vehicles can significantly improve the effectiveness of a typical RWIS application. Dedicated short range communication (DSRC) and cellular vehicle to everything (C‐V2X) technologies are extensively used for data exchange between vehicles (V2V) and between vehicles and road infrastructure (V2I or I2V) under the umbrella term of vehicle‐to‐everything (V2X) communications. Latency and coverage are key performance indicators of the vehicular network that determine how drivers react to risks in adverse road and weather conditions. V2X‐based connectivity mainly aims to offer low latency in message delivery, but it is not possible to obtain a wide‐range coverage due to significant propagation loss in the dedicated 5.9 GHz ITS frequency band. In this study, we presented a long range (LoRa)‐based RWIS application that uses I2 V communication at sub‐GHz bands. Our main contribution is proposing a novel method for RWIS implementations, where the LoRa gateways run in a half‐duplex way to collect information from road weather information stations in the uplink channel and then broadcast warning messages to vehicles in the downlink channel. To validate the applicability of the proposed method, we presented a feasibility study that includes transmission range and latency analysis. Our theoretical calculations' results validate the more extended transmission range and applicability of LoRa connectivity on RWIS applications, especially for common scenarios like black ice where the climate risks do not occur suddenly. We also showed that our methodology would be beneficial due to the ability to offer wide coverage, especially in the areas where cellular base stations have not yet existed or V2X road infrastructure has not yet been established.

Exergames and Immersive Virtual Reality as a Novel Therapy Approach in Multiple Sclerosis: Randomised Feasibility Study

Background: Multiple sclerosis is a chronic, inflammatory, neurodegenerative autoimmune disease caused by myelin loss in the central nervous system, which leads to motor and non-motor problems. The main objective of this study was to explore whether an immersive virtual reality (IVR) exercise programme would be feasible as a form of physical therapy for people with MS (pwMS). Methods: 18 participants (13 women; 45.06 years) were assigned to an experimental group (EG, n = 8) and a control group (CG, n = 10). The EG took part in a twice-weekly IVR exergame physical therapy programme—ExeRVIEM programme. A randomised, single-blind clinical trial was conducted and was registered in clinicaltrials (NCT05870254). Results: The intervention was feasible and safe. The participants completed the programme with no adverse effects (no symptoms on the Simulator Sickness Questionnaire), high usability (System Usability Scale 90.31%), and outstandingly positive post-game experiences (Game Experience Questionnaire 3.10/4). In addition, the GE significantly improved several of their functional capacities: increased lower limb strength (Five Times Sit-to-Stand Test p = 0.042), improved functional mobility, and reduced fall risk (Timed Up and Go Test-simple p = 0.009; Timed Up and Go Test-cognitive p = 0.003). There were no statistically significant differences between the groups. Conclusions: The findings support that the use of exergames and IVR as physical therapy in pwMS is feasible and safe. Furthermore, there is the suggestion of possible benefits to participants’ functional abilities, all of which position IVR as a promising tool for the rehabilitation of this neurodegenerative pathology affecting young adults.

Six-Week Supplementation with Creatine in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Magnetic Resonance Spectroscopy Feasibility Study at 3 Tesla

Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic medical condition with no specific pharmacological treatment. Creatine, a nutrient essential for maintaining energy homeostasis in the cells, is a candidate for interventions in ME/CFS. Methods: Fourteen participants with ME/CFS received supplementation with 16 g creatine monohydrate for 6 weeks. Before starting creatine and on the last day of treatment, participants underwent brain magnetic resonance spectroscopy (MRS) scanning of the pregenual anterior cingulate cortex (pgACC) and dorsolateral prefrontal cortex (DLPFC), followed by symptom, cognition, and hand-grip strength assessments. Results: Eleven participants completed the study. Creatine treatment increased creatine concentration in both the pgACC and DLPFC (p = 0.004 and 0.012, respectively), decreased fatigue and reaction time (RT) on congruent and incongruent trials of the Stroop test (p = 0.036 and 0.014, respectively), and increased hand-grip strength (p = 0.0004). There was a positive correlation between increases in pgACC creatine and changes in RT on Stroop congruent and incongruent trials (p = 0.048 and p = 0.022, respectively). Creatine was well tolerated, and none of the participants stopped treatment. Conclusion: Creatine supplementation over six weeks in ME/CFS patients increased brain creatine and improved fatigue and some aspects of cognition. Despite its methodological limitations, this study encourages placebo-controlled investigations of creatine treatment in ME/CFS.

Experiences with home monitoring technology in older adults with traumatic brain injury: a qualitative study.

Home monitoring systems utilising artificial intelligence hold promise for digitally enhanced healthcare in older adults. Their real-world use will depend on acceptability to the end user i.e. older adults and caregivers. We explored the experiences of adults over the age of 60 and their social and care networks with a home monitoring system installed on hospital discharge after sustaining a moderate/severe Traumatic Brain Injury (TBI), a growing public health concern. A qualitative descriptive approach was taken to explore experiential data from older adults and their caregivers as part of a feasibility study. Semi-structured interviews were conducted with 6 patients and 6 caregivers (N = 12) at 6-month study exit. Data were analysed using Framework analysis. Potential factors affecting acceptability and barriers and facilitators to the use of home monitoring in clinical care and research were examined. Home monitoring was acceptable to older adults with TBI and their caregivers. Facilitators to the use of home monitoring were perceived need for greater support after hospital discharge, the absence of sound and video recording, and the peace of mind provided to care providers. Potential barriers to adoption were reliability, lack of confidence in technology and uncertainty at how data would be acted upon to improve safety at home. Remote monitoring approaches are likely to be acceptable, especially if patients and caregivers see direct benefit to their care. We identified key barriers and facilitators to the use of home monitoring in older adults who had sustained TBI, which can inform the development of home monitoring for research and clinical use. For sustained use in this demographic the technology should be developed in conjunction with older adults and their social and care networks.

Technological and Mechanical Studies on Additively Manufactured Cellular Structures Made of the Ultrafuse 316L Composite Filament

Regular cellular materials produced using additive manufacturing (AM) techniques represent a significant development trend in modern engineering materials. Depending on the applied elementary unit cell of topology, it is possible to define the course of the structure deformation process in order to obtain the highest possible energy absorption effectiveness. This feature makes regular cellular structural materials particularly attractive for a number of industrial branches. This paper presents the results of technological trials and the results of experimental studies on the mechanical properties of regular cellular structures made using 3D printing technology under compression test loading conditions. The material used for their production was the Ultrafuse 316L filament and the fused filament fabrication (FFF) technique. The proposed material is a polymer-metal composite with a manufacturing process similar to metal injection moulding (MIM). The adopted research methodology included a feasibility study aimed at achieving material homogeneity and compression tests of the developed and manufactured regular cellular structures under quasi-static loading conditions. Several structural topologies were analysed. Experimental results indicated that regular cellular structures made from 316L steel exhibit high mechanical strength and extensive plastic deformation capabilities. The utilized in this work manufacturing technology used combines the advantages of 3D printing process with the potential of powder metallurgy. The proposed technique of structure manufacturing process is much cheaper than other based on melting metallic powders.

Protocol for a feasibility multi-centre randomised controlled trial of a pre-operative two-week very low-calorie diet to reduce steatosis prior to liver resection (RESOLVE)

BackgroundHepatic steatosis (HS) increases morbidity and mortality associated with liver surgery (LS). Furthermore, patients with HS are more likely to require a blood transfusion, which is associated with worse short and long-term outcomes. Patients with HS requiring LS receive no specific dietary treatment or advice. A very low-calorie diet (VLCD) is commonly used before gallbladder and bariatric surgery to reduce liver volumes and associated intraoperative morbidity. These diets typically provide 800–1200 kcal/day over a 2–4-week period. Limited evidence suggests that a VLCD in patients with LS may result in better outcomes.MethodsThis study aims to test the feasibility of delivering a multi-centre randomised clinical trial to compare a dietary intervention (VLCD plus motivational instructions) versus treatment as usual (TAU) in people with HS having LS. This study will provide high-quality data to estimate screening rates, recruitment, randomisation, retention, and intervention adherence. The study will also determine the definitive trial’s most clinically relevant primary outcome. The study will also estimate resource use and costs associated with the delivery of the intervention. Seventy-two adults ≥ 18 who are scheduled to undergo elective LS and have a magnetic resonance imaging (MRI) identified HS will be recruited. Acceptability to the dietary intervention will be evaluated with food diaries and focus groups. Clinical and patient-reported outcomes will be collected at baseline, pre- and post-surgery, day of discharge, plus 30- and 90-day follow-up.DiscussionThis feasibility study will provide data on the acceptability and feasibility of a dietary intervention for patients with HS having LS. The intervention has been developed based on scientific evidence from other clinical areas and patient experience; therefore, it is safe for this patient group. Patients with experience of LS and VLCDs have advised throughout the development of the study protocol. The findings will inform the design of a future definitive study.Trial registrationISRCTN Number 19701345. Date registered: 20/03/2023. URL: https://www.isrctn.com/ISRCTN19701345.