Feasibility Study Research Articles

Experimental and feasibility study of bio-waste valorization through pyrolysis for energy and materials production in the concept of circular economy

The pyrolysis and co-pyrolysis characteristics of large abundant bio-wastes, namely date pits (DP), peanut shells (PS), coffee grounds (CG), and tea waste (TW) were investigated in detail. The TG/DTG and pyrolysis procedures were used to examine the thermal pyrolysis behavior of these agro-wastes and their blends (50%CG/50%DP, 50%CG/50%PS, 50%DP/50%PS, 50%TW/50% DP,50%TW/50%PS and 50%CG/50% TW by weight). The characterization of these feedstock has shown their suitability for energy and material valorization. Experiments were carried out in a batch pyrolysis at a medium heating rate of 10 °C/min. The goal was to identify the best combination aiming to produce either char or hydrogen-rich gas, which can contribute to the development of the circular bio-economy. It was demonstrated that pyrolysis favored the liquid product, fluctuating from 34.31% (TW) to 50.92% (DP), while the co-pyrolysis greatly increased the gaseous product, which ranged between 42.02% (TW-DP) and 55.17% (PS-TW). The blending of CG and PS resulted in heightened reactivity, leading to an enhanced generation of H2 (34.44%). The optimal mixture was found to be CG-TW, showcasing superior performance in terms of gas quality (38.39% H2) and yield (53.74%). This outcome underscores the potential of CG and TW as a synergistic blend for efficient hydrogen-rich gas production. The FTIR findings revealed that the recovered biochars have the potential to serve as solid fuels, biofertilizers, or carbon materials. Additionally, they could be used as eco-friendly precursors for chemical and related industries. By analyzing various waste mixtures and their respective pyrolysis properties, this research aims to contribute to the development of sustainable waste management practices as well as efficient energy and material production methods.

Empowering healthcare professionals in West Africa-A feasibility study and qualitative assessment of a dietary screening tool to identify adults at high risk of hypertension.

Dietary risks significantly contribute to hypertension in West Africa. Food frequency questionnaires (FFQs) can provide valuable dietary assessment but require rigorous validation and careful design to facilitate usability. This study assessed the feasibility and interest of a dietary screening tool for identifying adults at high risk of hypertension in Nigeria. Fifty-eight (58) consenting adult patients with hypertension and their caregivers and 35 healthcare professionals from a single-centre Nigerian hospital were recruited to complete a 27-item FFQ at two-time points and three 24-hour recalls for comparison in a mixed method study employing both quantitative questionnaires and qualitative techniques to elicit free form text. Data analyses were conducted using R software version 4.3.1 and NVivo version 14. The trial was registered with ClinicalTrials.gov: NCT05973760. The mean age of patients was 42.6 ± 11.9 years, with an average SBP of 140.3 ± 29.8 mmHg and a BMI of 29.5 ± 7.1 Kg/m2. The adherence rate was 87.9%, and the mean completion time was 7:37 minutes. 96.6% of patients found the FFQ easy to complete, comprehensive, and valuable. A minority reported difficulty (3.4%), discomfort (10.3%), and proposed additional foods (6.9%). Healthcare professionals considered the dietary screening tool very important (82.9%) and expressed a willingness to adopt the tool, with some suggestions for clarification. Patients and healthcare professionals found the screening tool favourable for dietary counselling in hypertension care. The tailored dietary screening tool (FFQ) demonstrated promising feasibility for integration into clinical care as assessed by patients and healthcare professionals. Successful implementation may benefit from proactive time management and addressing training needs. This user-centred approach provided key insights to refine FFQ and set the foundation for ongoing validity testing and evaluation in clinical practice.

Laser Powder Bed Fusion Processing of Low Cost CoCrFeNiMoxNby High Entropy Alloys with Promising High-Temperature Properties via In Situ Alloying Commercial Powders

A blend of only commercial powders, including Ni625, CoCrF75, and 316L, were used as the raw material for fabricating non-equiatomic CoCrFeNiMoxNby high entropy alloys (HEAs) through laser powder bed fusion (PBF-LB/M) via in situ alloying, instead of using pure elemental powders, thus reducing the raw materials cost. The rapid cooling inherent in the PBF-LB/M process facilitated the dissolution of Mo and Nb, resulting in a single FCC phase characterized by high relative densities. High-temperature tensile tests were conducted at room temperature, 700 °C, 800 °C, and 900 °C, revealing mechanical properties that surpassed those reported in existing HEA literature. The remarkable strength of the HEAs developed in this study primarily stemmed from the incorporation of Mo and Nb, leading to the precipitation of Mo and Nb-rich lave phases at elevated temperatures. While constraining elongation when confined to grain boundaries, these precipitates enhanced strength without compromising elongation when distributed throughout the matrix. This work is a feasibility study to explore the usage of commodity compositions from the market to develop HEAs using PBF-LB/M, which opens the possibility of using scraps to further the development of new materials. Consequently, this study presents a rapid and cost-effective approach for HEA development, improving efficiency and sidestepping the direct utilization of critical raw metals for sustainable manufacturing. Moreover, this work also underscores the outstanding mechanical performance of these HEAs at high temperatures, paving the way for the design of innovative alloys for future high-temperature applications.

Feasibility Study of UHPC Reinforced Masonry Structure

With the increase of service life of masonry structure and the damage of masonry structure caused by external environment, the structure will be difficult to meet the design requirements. It is necessary to repair and reinforce the existing structure or replace the original structure with a new type of composite structure. ultra-high performance concrete (UHPC) is a kind of high strength, high ductility, high durability material, which has the advantages of almost impermeability, almost no carbonization, and almost zero chloride ion penetration and sulfate penetration. UHPC has been widely used in the field of concrete structure reinforcement, whether the masonry structure can be better strengthened has become the research content of this paper. Basic mechanics of UHPC materials at home and abroad By systematically combing and summarizing the research progress of performance and reinforcement design, the feasibility of UHPC reinforced masonry structure is obtained.

Behavior Change Approaches in Digital Technology-Based Physical Rehabilitation Interventions Following Stroke: Scoping Review.

Digital health technologies (DHTs) are increasingly used in physical stroke rehabilitation to support individuals in successfully engaging with the frequent, intensive, and lengthy activities required to optimize recovery. Despite this, little is known about behavior change within these interventions. This scoping review aimed to identify if and how behavior change approaches (ie, theories, models, frameworks, and techniques to influence behavior) are incorporated within physical stroke rehabilitation interventions that include a DHT. Databases (Embase, MEDLINE, PsycINFO, CINAHL, Cochrane Library, and AMED) were searched using keywords relating to behavior change, DHT, physical rehabilitation, and stroke. The results were independently screened by 2 reviewers. Sources were included if they reported a completed primary research study in which a behavior change approach could be identified within a physical stroke rehabilitation intervention that included a DHT. Data, including the study design, DHT used, and behavior change approaches, were charted. Specific behavior change techniques were coded to the behavior change technique taxonomy version 1 (BCTTv1). From a total of 1973 identified sources, 103 (5%) studies were included for data charting. The most common reason for exclusion at full-text screening was the absence of an explicit approach to behavior change (165/245, 67%). Almost half (45/103, 44%) of the included studies were described as pilot or feasibility studies. Virtual reality was the most frequently identified DHT type (58/103, 56%), and almost two-thirds (65/103, 63%) of studies focused on upper limb rehabilitation. Only a limited number of studies (18/103, 17%) included a theory, model, or framework for behavior change. The most frequently used BCTTv1 clusters were feedback and monitoring (88/103, 85%), reward and threat (56/103, 54%), goals and planning (33/103, 32%), and shaping knowledge (33/103, 32%). Relationships between feedback and monitoring and reward and threat were identified using a relationship map, with prominent use of both of these clusters in interventions that included virtual reality. Despite an assumption that DHTs can promote engagement in rehabilitation, this scoping review demonstrates that very few studies of physical stroke rehabilitation that include a DHT overtly used any form of behavior change approach. From those studies that did consider behavior change, most did not report a robust underpinning theory. Future development and research need to explicitly articulate how including DHTs within an intervention may support the behavior change required for optimal engagement in physical rehabilitation following stroke, as well as establish their effectiveness. This understanding is likely to support the realization of the transformative potential of DHTs in stroke rehabilitation.

Lagrangian dynamics and regularity of the spin Euler equation

We derive the spin Euler equation for ideal flows by applying the spherical Clebsch mapping. This equation is based on the spin vector, a unit vector field encoding vortex lines, instead of the velocity. The spin Euler equation enables a feasible Lagrangian study of fluid dynamics, as the isosurface of a spin-vector component is a vortex surface and material surface in ideal flows. We establish a non-blowup criterion for the spin Euler equation, suggesting that the Laplacian of the spin vector must diverge if the solution forms a singularity at some finite time. The direct numerical simulations (DNS) of three ideal flows – the vortex knot, the vortex link and the modified Taylor–Green flow – are conducted by solving the spin Euler equation. The evolution of the Lagrangian vortex surface illustrates that the regions with large vorticity are rapidly stretched into spiral sheets. The DNS result exhibits a pronounced double-exponential growth of the maximum norm of Laplacian of the spin vector, showing no evidence of the finite-time singularity formation if the double-exponential growth holds at later times. Moreover, the present criterion with Lagrangian nature appears to be more sensitive than the Beale–Kato–Majda criterion in detecting the flows that are incapable of producing finite-time singularities.

Techno-economic and environmental feasibility study of MILD combustion in domestic utility boilers under partial load operation

This paper aims to achieve the benefits of MILD combustion, such as enhanced thermal efficiency with simultaneous NOx reduction in existing conventional domestic hot water utility boilers which encounter partial heat loads. For this purpose, a system based on waste heat recovery and flue gas recirculation (FGR) is introduced to perform techno-economic and environmental studies under continuous fluctuations of heat load demand in a typical building at various climate conditions. Technical investigations on several types of utility boilers revealed that MILD combustion could be implemented only in modulation boilers, which can serve combustion stability requirements in turndown conditions due to partial load demands. Up to 6 % fuel saving, which aligns with a commensurate decrease in CO2 emissions and a minimum 75 % reduction in NOx emissions, is foreseeable by manipulating optimal FGR for each specific boiler in various climate conditions. Finally, economic investigation demonstrated that the payback period for the proposed revamped system is less than one year for most climates.

Feasibility Study of Anisotropic Full-Waveform Inversion with DAS Data in a Vertical Seismic Profile Configuration at the Newell County Facility, Alberta, Canada

Feasibility Study of Anisotropic Full-Waveform Inversion with DAS Data in a Vertical Seismic Profile Configuration at the Newell County Facility, Alberta, Canada

Fusion of cellulose microspheres with pulp fibers: Creating an unconventional type of paper

Cellulose microspheres (CMS) are a type of spherical regenerated cellulose particles with versatile properties which have been used as carrier materials in medical and technical applications. The integration of CMS into paper products opens up novel application scenarios for paper products in a wide range of fields. However, the incorporation of CMS carriers into paper products is challenging and hitherto no reports do exist in literature. Here, we present a feasibility study to incorporate up to 50 w.% CMS in paper hand sheets using retention aids. Our primary observations highlight the successful formation of uniform paper hand sheets retaining its tensile strengths at elevated CMS concentrations. Sheets with high CMS contents exhibit an increase in density and display enhanced surface smoothness — an outcome of a CMS layer forming atop the fiber base — which effectively bridges voids and rectifies surface irregularities as supported by Gurley testing, infinite focus microscopy and scanning electron microscopy. While our primary objective centered on the general feasibility to manufacture CMS-containing papers, the resulting composite scaffold carries significant potential as a platform for innovative, functional paper-based materials.

Feasibility Study of a Novel Secondary Zinc‐Flow Battery as Stationary Energy Storage System: From Design to Environmental Assessment

Herein, a zinc‐air flow battery (ZAFB) as an environmentally friendly and inexpensive energy storage system is investigated. For this purpose, an optimized ZAFB for households is designed based on the most recent publications, and an economic and ecological analysis of the system is carried out. The results show that the customer price of the designed ZAFB is estimated at ≈5000 € and is thus about one‐third lower than the quoted price for a comparable vanadium flow battery (VFB). The carbon footprint (CF) analysis shows that especially the alkaline electrolyte and the silver‐containing gas diffusion electrode have a high share of the greenhouse gas emissions of the ZAFB system. However, the CF is 41% lower than that of the VFB, highlighting the great potential of the ZAFB as an alternative home storage system.

P050 Determining the feasibility of a multi-centre randomised clinical trial to test the effectiveness of integrated symptom tracking for managing rheumatoid arthritis

Abstract Background/Aims In a series of studies, we co-developed and piloted the remote monitoring of rheumatoid arthritis (REMORA) system. REMORA enables patients to daily track symptoms via their smartphone and integrates this data into their electronic health record for discussion during routine clinic visits. This offers the opportunity to make better, and shared, treatment decisions and improve disease management. The effectiveness of integrated daily symptom tracking on clinical and patient-reported outcomes will be tested in a multi-centre stepped wedge randomised clinical trial (RCT). Here, we present the results of the REMORA feasibility study to test trial procedures and intervention delivery. Methods Across two NHS sites in the Northwest of England we aimed to recruit 60 patients, aged ≥18 years with rheumatoid arthritis (RA) or inflammatory arthritis (IA), and access to an Android/iOS smartphone with daily internet access. Participants were asked to complete a baseline web-survey and use the REMORA app to collect daily symptom reports for up to six months. Clinical care teams extracted data from participants’ medical records for all baseline and follow-up appointments, including disease activity scores. To assess feasibility, we reported recruitment rates, participants’ uptake of and adherence to daily symptom tracking, and outcome data completeness. We also compared characteristics of a) those who consented vs. trackers (defined as submitting ≥1 symptom report, i.e., successful intervention uptake), and b) high adherers (symptoms reported on > 60% days) vs. low adherers (symptoms reported on < 25% days). Results A total of 130 patients were screened across study sites, and 52 were eligible and provided consent to take part (40.0%). Of those, 32 (61.5%) initiated symptom tracking; their demographic characteristics were broadly similar to those who consented, though more people of white ethnicity appeared higher in the tracker group (93.8% (95% CI 79.2-99.2) vs 86.5% (74.2-94.4), respectively). Participants completed at least one symptom report on 63.2% of study days (2384/3771 days). We observed few differences between low vs high adherers, though low adherers (n = 6) were younger (median (IQR) years: 41.5 (34.5-55.3)) than the high engagers (n = 20; 61.0 (50.5-65.3)) and had a shorter disease duration (years: 1.0 (0-5.8) vs 3.0 (0.8-10.8)). In total, 48 consented participants had at least one follow-up appointment during the study window; 46 (95.8%) had complete primary outcome data. Conclusion Across two clinical sites, we determined that the procedures and intervention delivery designed for use within a future multi-centre stepped wedge RCT of the REMORA system were feasible for recruitment, adherence to the intervention and completion of the primary outcome. However, uptake of the intervention was lower than we hoped. To enhance intervention uptake in the main trial, we clarified inclusion criteria, improved patient information on what is required to initiate symptom tracking and modified our supporting materials. Disclosure K.L. Druce: None. M. Parkes: None. R. Bravo: None. D. Griffiths-Jones: None. S.N. van der Veer: None. W. Dixon: Consultancies; consultancy fees from Google unrelated to this work. J. McBeth: None.

P007 Successful use of patient initiated follow-up in a tertiary paediatric rheumatology service

Abstract Background/Aims Patient initiated follow-up (PIFU) is a national strategy enabling patients or carers to initiate contact with a service rather than a traditional model of routine scheduled appointments. PIFU enables patient empowerment and elective recovery after the Covid-19 pandemic. NHSE identified Paediatrics as appropriate for PIFU, but specific measures are needed to ensure safeguarding of paediatric patients is maintained. Methods With NHSE & I support and extrapolating guidance implementing PIFU in adult rheumatology services, we developed a clinical pathway that included safeguarding/governance structures within Paediatric Rheumatology at Alder Hey Children’s Hospital. Two strategies were developed - PIFU culminating with either a timed return (PEND) or discharge (DISCHARGE) model. A PIFU feasibility study in paediatric rheumatology initially targeted three index conditions (arthritis, mechanical pain and primary Raynaud’s) in March 2022. This was extended within a Plan-Do-Study-Act model of Quality Improvement. Results We placed 536 patients within PIFU pathways (PEND = 297, DISCHARGE = 239). The monthly usage of PIFU increased from <10 patients per month in March 2022 to > 40 patients per month in August 2023 with expansion of PIFU conditions. Within this time frame the number of patients put through the DISCHARGE model increased steadily to 60% of the monthly proportion as clinician confidence in PIFU increased. We demonstrate an 11% (total Rheumatology patients) PIFU rate over the study time frame, with a 2.7% (15/536) reactivation rate. Where calculable, timescale for review following activation was <48 hours. In our experience, patients/families are comfortable with PIFU and feel reassured by the safety-net provided. Decision for PIFU PEND/DISCHARGE is made in partnership with patients/families. As well as increased use within Rheumatology, PIFU use has extended to 80% of clinical teams across Alder Hey. The Trust-wide PIFU rate of 10% in September 2023 is double the original NHS England guidance target of 5%. Conclusion We advocate safety of PIFU in the correct population and its ability to empower patients. Table 1 shows the significant impact that correct use of PIFU can have on increasing capacity for seeing new patients, decreasing time to review and matching the number of patient reviews to referrals. Disclosure W. Calvert: None. J. Spinty: None. L.J. McCann: None. G. Cleary: None.

Feasibility study on the optimal design method of ground-water source hybrid heat pump system applied to office buildings

In order to reduce the energy consumption of buildings, a ground source heat pump (GSHP) system was introduced to reduce the building energy consumption. However, general GSHP systems are not as popular as photovoltaic and thermal systems owing to soil imbalances and performance degradation during long-term operation. To solve this problem, we propose a ground-water source hybrid heat pump (GWHP) system. GWHP systems can simultaneously use ground and water sources to avoid soil imbalance and degradation. In this study, we proposed a GWHP system and investigated its feasibility as a replacement for a GSHP system in terms of performance and heat source temperature. In addition, an optimal capacity design method for the GWHP system is presented to evaluate its economic feasibility. The performance and economic analysis show that the cooling and heating performance of the proposed GWHP was 15 % and 3 % better, respectively, compared to the existing GSHP system. Our results also showed that the proposed design method was approximately 5.3 % less expensive than the existing GSHP systems. The GWHP system could be a suitable alternative to the GSHP system, as confirmed by both the energy simulation and cost analysis.

Empowering School Staff to Support Pupil Mental Health Through a Brief, Interactive Web-Based Training Program: Mixed Methods Study.

Schools in the United Kingdom and elsewhere are expected to protect and promote pupil mental health. However, many school staff members do not feel confident in identifying and responding to pupil mental health difficulties and report wanting additional training in this area. We aimed to explore the feasibility of Kognito's At-Risk for Elementary School Educators, a brief, interactive web-based training program that uses a simulation-based approach to improve school staff's knowledge and skills in supporting pupil mental health. We conducted a mixed methods, nonrandomized feasibility study of At-Risk for Elementary School Educators in 6 UK primary schools. Our outcomes were (1) school staff's self-efficacy and preparedness to identify and respond to pupil mental health difficulties, (2) school staff's identification of mental health difficulties and increased risk of mental health difficulties, (3) mental health support for identified pupils (including conversations about concerns, documentation of concerns, in-class and in-school support, and referral and access to specialist mental health services), and (4) the acceptability and practicality of the training. We assessed these outcomes using a series of questionnaires completed at baseline (T1), 1 week after the training (T2), and 3 months after the training (T3), as well as semistructured qualitative interviews. Following guidance for feasibility studies, we assessed quantitative outcomes across time points by comparing medians and IQRs and analyzed qualitative data using reflexive thematic analysis. A total of 108 teachers and teaching assistants (TAs) completed T1 questionnaires, 89 (82.4%) completed T2 questionnaires, and 70 (64.8%) completed T3 questionnaires; 54 (50%) completed all 3. Eight school staff members, including teachers, TAs, mental health leads, and senior leaders, participated in the interviews. School staff reported greater confidence and preparedness in identifying and responding to mental health difficulties after completing the training. The proportion of pupils whom they identified as having mental health difficulties or increased risk declined slightly over time (medianT1=10%; medianT2=10%; medianT3=7.4%), but findings suggested a slight increase in accuracy compared with a validated screening measure (the Strengths and Difficulties Questionnaire). In-school mental health support outcomes for identified pupils improved after the training, with increases in formal documentation and communication of concerns as well as provision of in-class and in-school support. Referrals and access to external mental health services remained constant. The qualitative findings indicated that school staff perceived the training as useful, practical, and acceptable. The findings suggest that brief, interactive web-based training programs such as At-Risk for Elementary School Educators are a feasible means to improve the identification of and response to mental health difficulties in UK primary schools. Such training may help address the high prevalence of mental health difficulties in this age group by helping facilitate access to care and support.

Examining factors influencing delay of construction projects in Tanzania: A case of Gerenzani- Mbagala BRT road

This study examined the factors influencing the delay in the Gerezani-Mbagala BRT road construction project in Dar es Salaam. Specifically, the study examined client and consultant related factors that resulted in the delay in road construction in the study area. The study was guided by resource-based theory. The study used a descriptive research design and adopted purposive and stratified sampling techniques to select 50 members of the sample of the study. On the other hand, a questionnaire and interview tools were used to solicit information from the respondents. Additionally, the appropriate model for data analysis was the logistic regression model. The findings showed that limited funds provided by the client and poor communication had statistically significant associations with project delays in the Gerezani-Mbagala BRT construction project. Also, the results revealed that a delay in approving major changes and a lack of experience among the consultants had a statistically significant influence on the delays in the Gerezani-MbagalaBRT construction project. The study further revealed that delays in payments from the client and rework due to errors made by the construction personnel were significantly associated with project delays in the Gerezani-Mbagala BRT construction project. The study concludes that client-related and consultantrelated significantly caused the delays in the Gerezani-Mbagala BRT construction project. The study recommends that the client should provide enough time to produce project briefs and other feasibility studies, as this would lessen the impact of inaccurate project cost estimation, unforeseen site circumstances, and slow site clearances on the delivery of the construction project.

An innovative PCM-modified lining system for energy tunnel: From concept to numerical investigations

The rich geothermal stored in rock mass would result in high temperature to tunnels. This not only makes condition worse to workers, but also wastes geothermal energy and increases cost to adjust the internal environmental temperature. This motivates the present feasibility study on an innovative PCM-modified lining system of conventional energy tunnel, which generally makes use of ground source heat pump (GSHP). That is, the PCM-modified concrete regulates the thermal properties of tunnel linings installed with pipe loops of GSHP. To verify the concept of the new system, a finite element model (FEM) describing it is established, based on a case of high geothermal tunnel. Simulation of the heat conducting process of tunnel linings starting from hydration of cement during cast-in-place concrete, thermal conductivity from surrounding rock mass, circulating of GSHP, phase change within the PCM-modified linings, and boundary effect since ventilation are considered in the modeling. The results demonstrate that the new system would mitigate the level of thermal discomforts during construction stage, and it can improve the stability and efficiency in energy extraction in operation stage. Parametric study on the GSHP with PCM-modified linings gives that the better heat reduction performance can be obtained with the smaller intermittent ratio (IR) of GSHP, smaller temperature range of phase change, and larger latent heat, and higher exchanger rate can be obtained with the larger IR and larger latent heat.

Techno-Economic Feasibility of Reverse Osmosis Desalination Scale Coupled with Solar Energy: Case of Algeria

B Brackish water and seawater desalination have become important freshwater sources in arid and semi-arid regions suffering from water scarcity. Fortunately, the availability of solar energy provides an excellent opportunity to replace conventional energy with renewable energy for desalination system power. However, technical and economic feasibility studies must be carried out according to the characteristics of each region to assess its economic feasibility. This study assessed the techno-economic feasibility of a solar-powered desalination small-scale BWRO with a capacity of 2.016 m3/day. Two scenarios were proposed: a desalination station powered by a public network without a solar energy system (On-Grid) and a second powered by photovoltaic panels (Off-Grid). The result shows that the water production cost of the Off-Grid system (0.33 $/m3) was about 1.14 times lower than the water production cost of the On-Grid system (0.38 $/m3). The economic analysis result shows that the reverse osmosis desalination system coupled with a photovoltaic system (Off-Grid) is an economically suitable option for satisfying the increasing freshwater product demand compared to the grid-powered system (On-Grid), especially in arid areas.

Rapid diagnosis of bloodstream infections using a culture-free phenotypic platform

BackgroundBloodstream infections (BSIs) are a life-threatening acute medical condition and current diagnostics for BSIs suffer from long turnaround time (TAT). Here we show the validation of a rapid detection-analysis platform (RDAP) for the diagnosis of BSIs performed on clinical blood samplesMethodsThe validation was performed on a cohort of 59 clinical blood samples, including positive culture samples, which indicated confirmed bloodstream infections, and negative culture samples. The bacteria in the positive culture samples included Gram-positive and Gram-negative pathogenic species. RDAP is based on an electrochemical sandwich immunoassay with voltage-controlled signal amplification, which provides an ultra-low limit of detection (4 CFU/mL), allowing the platform to detect and identify bacteria without requiring culture and perform phenotypic antibiotic susceptibility testing (AST) with only 1–2 h of antibiotic exposure. The preliminary diagnostic performance of RDAP was compared with that of standard commercial diagnostic technologies.ResultsUsing a typical clinical microbiology laboratory diagnostic workflow that involved sample culture, agar plating, bacteria identification using matrix-assisted laser desorption ionization time-of-flight (MALDI TOF) mass spectrometry, and AST using MicroScan as a clinical diagnostic reference, RDAP showed diagnostic accuracy of 93.3% and 95.4% for detection-identification and AST, respectively. However, RDAP provided results at least 15 h faster.ConclusionsThis study shows the preliminary feasibility of using RDAP to rapidly diagnose BSIs, including AST. Limitations and potential mitigation strategies for clinical translation of the present RDAP prototype are discussed. The results of this clinical feasibility study indicate an approach to provide near real-time diagnostic information for clinicians to significantly enhance the treatment outcome of BSIs.

Fulfilling the Role of a Parent While Undergoing Treatment for Cancer: A Review of the Literature and the Potential Impact of Childcare Support on Cancer Outcomes.

Breast cancer is the most prevalent malignancy among adolescents and young adults (AYAs). Despite the efficacy of chemotherapy, AYA patients contend with psychosocial challenges, including psychological distress and financial toxicity, exacerbated further by those with dependent children. Parenting responsibilities intersect with cancer care, impacting both family dynamics and treatment adherence. Despite recognized needs, however, the impact of parenting concerns or even parenting status and the presence of dependents has not been systematically addressed and there is a paucity of interventional research regarding patients with cancer as concomitant caregivers. A feasibility study conducted by the Brown University Oncology Cooperative Group demonstrated the potential benefits of providing financial assistance for childcare, both improving treatment adherence and reducing distress among participants. Similar interventions have shown promise in addressing financial hardships for AYA patients with cancer who are concomitant caregivers. Ultimately, parenting concerns have a significant impact on medical decision-making, and further interventional research on childcare support is required to examine the ways in which health systems can improve family stability, stress, and quality of life.

An Underactuated Cable-Driven Parallel Robot for Marine Automated Launch and Recovery Operations

Abstract This paper presents the feasibility study and preliminary testing of an underactuated cable-driven parallel robot for automated launch and recovery operations on the sea surface. The robot frame is mounted onto a primary vessel (PV) subject to sea-induced motions. During launch, the end-effector (EE) is required to deploy a secondary vessel (SV) by lowering it from the PV onto the sea surface. During recovery, the ee has to track and grasp a SV and the EE-SV assembly needs to be stabilized during lifting from the sea surface to the PV. Sea conditions and the underactuated nature of the ee influence the operational feasibility and the overall robot performance. The paper presents the conceptual design and the robot model, as well as the methodologies for winch dimensioning and robot control. An extensive simulation campaign is conducted to optimize performances and assess the system behavior. Finally, the operations are tested on a scaled prototype in a laboratory environment.